PCR芯片及基因列表.doc

Apoptosis and Cell Cycle PCR Array 细胞凋亡与细胞周期基因芯片凋亡PCR芯片细胞凋亡PCR芯片 384HT细胞周期PCR芯片Apoptosis PCR Array凋亡PCR芯片Catalog No. PAHS-012A（人）Catalog No. PAMM-012A（小鼠）Catalog No. PARN-012A（大鼠）The Apoptosis RT Profiler PCR Array profiles the expression of 84 key genes involved in apoptosis, or programmed cell death. The array includes the TNF ligands and their receptors; members of the bcl-2, caspase, IAP, TRAF, CARD, death domain, death effector domain, and CIDE families; as well as genes involved in the p53 and ATM pathways. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to apoptosis with this array.细胞凋亡RT Profiler PCR Array可以同时测定84个与凋亡即细胞程序性死亡有关的关键基因。其中包括TNF配基及其受体，Bcl-2家族成员、caspase、IAP、TRAF、CARD、死亡结构域、死亡效应结构域和CIDE家族，同时还包括p53和ATM信号通路相关的基因。利用实时定量PCR，你可以方便并且可信地对与凋亡相关的基因进行同时检测。TNF Ligand Family: CD40LG (TNFSF5), FASLG (TNFSF6), LTA, TNF, TNFSF10, TNFSF7, TNFSF8. TNF Receptor Family: CD40 (TNFRSF5), FAS (TNFRSF6), LTBR, TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF7, TNFRSF9. Bcl-2 Family: BAD, BAG1, BAG3, BAG4, BAK1, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L2, BCLAF1, BID, BIK, BNIP1, BNIP2, BNIP3, BNIP3L, HRK, MCL1. Caspase Family: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9. IAP Family: BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8. TRAF Family: TRAF2, TRAF3, TRAF4. CARD Family: APAF1, BCL10, BIRC2, BIRC3, CARD4, CARD6, CARD8, CASP1, CASP2, CASP4, CASP5, CASP9, CRADD, NOL3, PYCARD, RIPK2. Death Domain Family: CRADD, DAPK1, FADD, FAS (TNFRSF6), TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD. Death Effector Domain Family: CASP8, CASP10, CFLAR, FADD. CIDE Domain Family: CIDEA, CIDEB, DFFA. p53 and DNA Damage Response: ABL1, AKT1, APAF1, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, GADD45A, TP53, TP53BP2, TP73. Anti-apoptosis: AKT1, BAG1, BAG3, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BFAR, BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CFLAR, FAS (TNFRSF6), IGF1R, MCL1, TNF, TNFRSF7. TNF配基家族;TNF受体家族；Bcl-2家族；Caspase 家族；IAP家族；TRAF家族；CARD家族；死亡结构域家族；死亡效应结构域家族；CIDE结构域；P53和DNA损伤反应有关基因；抗凋亡基因Apoptosis PCR Array 384HT细胞凋亡PCR芯片 384HTCatalog No. PAHS-3012A（人）The Human Apoptosis RT Profiler PCR Array 384HT profiles the expression of 370 key genes involved in apoptosis, or programmed cell death. The array includes the TNF ligands and their receptors; members of the bcl-2 family, BIRC (baculoviral IAP repeat) domain proteins, CARD domain (caspase recruitment domain) proteins, death domain proteins, TRAF (TNF receptor-associated factor) domain proteins and caspases. These 370 genes are also grouped by their functional contribution to apoptosis, either anti-apoptotic regulation or the induction of apoptosis by death domain receptors, DNA damage, oxidative stress, or extracellular and intracellular signals. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes related to apoptosis with this array.细胞凋亡RT Profiler PCR Array384HT可以同时测定370个与细胞凋亡、程序性死亡相关的关键基因的表达谱。其中包括TNF配体及其受体、bcl-2家族成员、BIRC（baculoviral）结构域蛋白、CARD（caspase recruitment domain）结构域蛋白、死亡结构域蛋白、TRAF（TNF receptor-associated facor）结构域蛋白和caspases。这370个基因涉及以下几种功能：凋亡、通过死亡结构域受体诱导凋亡或抗凋亡、DNA损伤、氧化应激以及细胞内和细胞外信号转导。利用实时定量PCR，你可以方便并且可信地对与凋亡相关的基因进行同时检测。TNF Domain Proteins: EDA, FASLG, LTA, LTB, TNF, TNFSF10, TNFSF14, TNFSF15, TNFSF8.TNFR Domain Proteins: CD27, CD40, FAS, LTBR, NGFR, TNFRSF10A, TNFRSF10B, TNFRSF10D, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF6B, TNFRSF8, TNFRSF9.BCL2 and BAG Domain Proteins: BAG1, BAG3, BAG4, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L2, MCL1.BIR Domain Proteins: BIRC2, BIRC3, BIRC4, BIRC5, BIRC6, BIRC7, BIRC8, NAIP (BIRC1).CARD Domain Proteins: APAF1, BCL10, BIRC2, BIRC3, CARD10, CARD11, CARD14, CARD6, CARD8, CARD9, CASP1, CASP2, CASP4, CASP5, CASP9, CRADD, ICEBERG, INCA, NLRP1 (NALP1), NOD1, NOD2, NOL3, PYCARD, RFWD2 (COP1), RIPK2.DEATH Domain Proteins: CRADD, DAPK1, EDAR, FADD, LRDD, MALT1, NFKB1, NFKB2, NGFR, RIPK1, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD.TRAF Domain Proteins: TRAF2, TRAF3, TRAF5, TRAF7.Caspases and Regulators: Caspases: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CFLAR, CRADD, ICEBERG, INCA, MALT1, PYCARD, RFWD2 (COP1). Caspase activators: AIFM3, APAF1, BAX, BBC3, BCL2L10, BCL2L13, CARD8, CASP1, CASP8AP2, CASP9, COL4A3, CYCS, DIABLO, EIF2AK3, F2, F2R, FOXL2, HIP1, HSPE1, IFNB1, IFT57, LCK, MAP3K5, MOAP1, MTCH1, MYC, NLRC4, NLRP1, NLRP12, NLRP2, NLRP3, NOD1, PMAIP1, PYCARD, STAT1, TNFRSF10A, TNFRSF10B, TNFSF15, TP53, TPD52L1, VCP. Caspase inhibitors: BIRC4, BIRC5, CD27, DHCR24, HBXIP, IFI6, SFN, TNFAIP8, TNFSF14, TRIAP1. Anti-Apoptosis Genes: Positive regulation of anti-apoptosis: BCL2L1, BRE, CD28, ERC1, MAPK8IP2, OPA1, PRKAA1, RASA1. Negative regulation of anti-apoptosis: PIK3R2, RTN4, TNFAIP8.Other genes involved in anti-apoptosis: AATF, AKT1, ALOX12, ANXA1, ANXA4, API5, ATF5, AVEN, AZU1, BAG1, BAG3, BAG4, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BDNF, BECN1, BFAR, BIRC2, BIRC3, BIRC4, BIRC5, BIRC6, BIRC7, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CBX4, CCL2, CD27, CD40LG, CEBPB, CFDP1, CFL1, CFLAR, CRYAA, CRYAB, DAD1, DDAH2, DHCR24, EEF1A2, FAIM, FAIM2, FAS, FOXO1, GDNF, GFRAL, GLO1, GSTP1, HBXIP, HD, HDAC1, HDAC3, HIPK3, HMGB1, HSP90B1, HSPA1B, HSPA9, HSPB1, HTATIP2, IER3, IFI6, IGF1R, IL10, IL1A, IL2, IL31RA, MALT1, MCL1, MKL1, MPO, MTL5, MYBL2, MYO18A, NAIP, NFKB1, NME5, NOL3, NOTCH2, NPM1, NRG2, NTF3, PAK7, PAX7, PEA15, PIK3CA, PIM2, POGK, POLB, PRDX2, PRKCZ, PRLR, PROK2, PSEN1, RELA, RNF7, SEMA4D, SERPINB2, SERPINB9, SFRP1, SH3GLB1, SNCA, SOCS2, SOCS3, SON, SPHK1, SPP1, STAMBP, TAX1BP1, TBX3, TGFB1, TIAF1, TNF, TNFAIP3, TNFAIP8, TNFRSF10D, TNFRSF18, TNFRSF6B, TNFSF18, TPT1, TRIAP1, TSC22D3, TXNDC1, VHL, YWHAZ, ZC3HC1. Induction of Apoptosis: Induction of apoptosis via death domain receptors: BID, CRADD, DAXX, DEDD2, FADD, IL18, TNF, TNFRSF10B. induction of apoptosis by DNA damage: ABL1, AIFM1, BCL3, BRCA1, CHEK2, CIDEA, CIDEB, DYRK2, IFI16, MBD4, MSH6, PCBP4, PML, SFN, TP53, TP73.Induction of apoptosis by oxidative stress: GPX1, PRODH, RNF7, TP53I3 Induction of apoptosis by extracellular signals: ADORA1, BTK, CASP8AP2, CD28, CD38, CD5, CFLAR, DAP, DAP3, DAPK1, DPF2, FASTK, MAP3K5, NDUFA13, PDCD6, PRKCA, RIPK3, SPN, TIMP3, TNFRSF25. Induction of apoptosis by intracellular signals: CDKN1A, CUL1, CUL2, CUL3, CUL4A, CUL5, HIPK2, MYC, SART1. Other genes involved in induction of apoptosis: ACVR1B, AIFM2, AIFM3, ALOX15B, APOE, BAD, BAK1, BAX, BBC3, BCL10, BCL2L11, BCL2L13, BCLAF1, BIK, BNIP1, BNIP3, BNIP3L, BOK, CASP10, CASP3, CASP4, CASP6, CD2, CD27, CD70, CEBPB, CIDEC, COL4A3, DAPK2, DAPK3, DCC, DDX20, DEDD, DIABLO, EI24, ERCC2, ERCC3, ERN1, ERN2, FAS, FASLG, FEM1B, FOXL2, FOXO3, HD, HRK, HTATIP2, IFNA2, IFNB1, IKBKG, IKIP, IL19, INHA, INHBA, JMY, LALBA, LCK, LTA, MAL, MAP3K10, MAPK1, MX1, NDUFS3, NGFR, NLRP1, NLRP3, NME3, NOTCH2, NOX5, NUDT2, NUPR1, PDCD5, PLAGL1, PLAGL2, PLEKHF1, PLG, PMAIP1, PPP1R13B, PPP2CA, PPP2R1A, PPP2R1B, PRKCE, PRKRA, PRUNE2, PTEN, PTH, PYCARD, RPS3A, RUNX3, S100B, SAP30BP, SERINC3, SIPA1, SIVA1, SMNDC1, SST, SSTR3, STK17A, STK17B, TBX5, TIA1, TIAL1, TLR2, TNFRSF10A, TNFRSF19, TNFRSF9, TNFSF10, TNFSF14, TNFSF8, TP53BP2, TP73L, TPD52L1, TRADD, TRAF3, TRAIP, UNC13B, UTP11L, ZNF443. Other Regulators of Apoptosis: BAPX1, BCL6, CEBPG, DBP, DDIT3, GRM4, LGALS1, MADD, MAPK8, POU4F1, PROP1, RARG, STAT5A, STAT5B, TBK1, TDGF1, TRAF6, ZAK. TNF结构域家族;TNF受体家族；Bcl-2和BAG结构域家族；BIR结构域家族；CARD家族；死亡结构域家族；Caspase 家族；抗凋亡基因；促凋亡基因Cell Cycle PCR Array细胞周期PCR芯片Catalog No. PAHS-020A（人）Catalog No. PAMM-020A（小鼠）Catalog No. PARN-020A（大鼠）The Cell Cycle RTProfiler PCR Array profiles the expression of 84 genes key to cell cycle regulation. This array contains genes that both positively and negatively regulate the cell cycle, the transitions between the each of the phases, DNA replication, checkpoints and arrest. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the cell cycle with this array.细胞周期RT Profiler PCR Array可以同时测定84个与细胞周期调节有关的关键基因。这些基因包括细胞周期的正调控、负调控等调控因子、各细胞周期转换控制因子、DNA复制相关基因、检验点和细胞周期阻滞相关基因。利用实时定量PCR，你可以方便并且可信地对与细胞周期相关的基因进行同时检测。G1 phase and G1/S transition: ANAPC2, CCND1, CCNE1, CDC34, CDK4, CDK6, CDKN1B, CDKN3, CUL1, CUL2, CUL3, SKP2. S phase and DNA replication: ABL1, MCM2, MCM3, MCM4, MCM5, PCNA, RPA3, SUMO1, UBE1. G2 phase and G2/M transition: ANAPC2, ANAPC4, ARHI, BCCIP, BIRC5, CCNB1, CCNG1, CCNH, CCNT1, CCNT2, CDK5R1, CDK5RAP1, CDK7, CDKN3, CKS1B, CKS2, DDX11, DNM2, GTF2H1, GTSE1, HERC5, KPNA2, MNAT1, SERTAD1. M phase: CCNB2, CCNF, CDC2, CDC16, CDC20, MRE11A, RAD51. Cell cycle checkpoint and cell cycle arrest: ATM, ATR, BRCA1, BRCA2, CCNG2, CDC2, CDC34, CDK2, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN3, CHEK1, CHEK2, CUL1, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L2, NBS1, RAD1, RAD17, RAD9A, RB1, RBBP8, TP53. Regulation of cell cycle: ABL1, ANAPC2, ANAPC4, ARHI, ATM, ATR, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2, CCNE1, CCNF, CCNH, CCNT1, CCNT2, CDC16, CDC2, CDC20, CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A, CDKN1B, CKS1B, DDX11, E2F4, GADD45A, KNTC1, MKI67, PCNA, RAD9A, RB1, SKP2, TFDP1, TFDP2. Negative regulation of cell cycle: ATM, BAX, BRCA1, CDKN2B, RBL1, RBL2, TP53.G1期和G1/S期转换有关基因；S期和DNA复制有关基因；G2期和G2/M期转换有关基因；M期有关基因；细胞周期检验点和细胞周期阻滞基因；细胞周期调节因子；细胞周期副调控因子Cancer PCR Array 肿瘤PCR芯片肿瘤转移PCR芯片血管生成PCR芯片肿瘤转移PCR芯片血管生长因子与血管生成抑制因子PCR芯片Angiogenesis PCR Array血管生成PCR芯片Catalog No. PAHS-024A（人）Catalog No. PAMM-024A（小鼠）Catalog No. PARN-024A（大鼠）The Angiogenesis RT Profiler PCR Array profiles the expression of 84 key genes involved in modulating the biological processes of angiogenesis. The array includes growth factors and their receptors, chemokines and cytokines, matrix and adhesion molecules, proteases and their inhibitors, as well as transcription factors, all involved in the development of new blood vessels. Angiogenesis is a hallmark in the pathology of many diseases, including cancer, ischemia, atherosclerosis, and inflammatory diseases. Angiogenesis plays additional roles in normal development and physiological processes in adults, including wound healing and tissue regeneration. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to angiogenesis with this array.血管生成RT Profiler PCR Array可以同时测定调节84个与血管生成相关的关键基因表达谱。其中包括与新的血管发育有关的生长因子、生长因子受体、趋化因子、细胞因子、细胞外基质、黏附分子、蛋白酶及其抑制剂、转录因子等。血管生成是多种疾病的一个标志性事件，如肿瘤、局部缺血、动脉粥样硬化和炎症疾病。血管生成在正常发育和成人的生理过程中发挥重要功能，如伤口愈合和组织再生。利用实时定量PCR，你可以方便并且可信地对与之相关的基因进行同时检测。Angiogenic factors:Growth factors and receptors: ANGPT1, ANGPT2, ANPEP, ECGF1, EREG, FGF1, FGF2, FIGF, FLT1, JAG1, KDR, LAMA5, NRP1, NRP2, PGF, PLXDC1, STAB1, VEGF, VEGFC. Adhesion molecules: ANGPTL3, BAI1, COL4A3, IL8, LAMA5, NRP1, NRP2, STAB1. Proteases, inhibitors and other matrix proteins: ANGPTL4, PECAM1, PF4, PROK2, SERPINF1, TNFAIP2. Transcription factors and others: HAND2, SPHK1. Other factors involved in angiogenesis:Cytokines and chemokines: CCL11, CCL2, CXCL1, CXCL10, CXCL3, CXCL5, CXCL6, CXCL9, IFNA1, IFNB1, IFNG, IL1B, IL6, MDK, TNF. Other growth factors and receptors: EDG1, EFNA1, EFNA3, EFNB2, EGF, EPHB4, FGFR3, HGF, IGF1, ITGB3, PDGFA, TEK, TGFA, TGFB1, TGFB2, TGFBR1. Adhesion molecules: CCL11, CCL2, CDH5, COL18A1, EDG1, ENG, ITGAV, ITGB3, THBS1, THBS2. Proteases, inhibitors and other matrix proteins: LECT1, LEP, MMP2, MMP9, PLAU, PLG, TIMP1, TIMP2, TIMP3. Transcription factors and others: AKT1, HIF1A, HPSE, ID1, ID3, NOTCH4, PTGS1. 、血管生成因子；血管生成相关的其他因子Angiogenic Growth Factors & Angiogenesis Inhibitors PCR Array 血管生长因子与血管生成抑制因子PCR芯片Catalog No. PAHS-072A（人）Catalog No. PAMM-072A（小鼠）Catalog No. PARN-072A（大鼠）The Angiogenic Growth Factors & Angiogenesis Inhibitors RT Profiler PCR Array profiles the expression of 84 growth factors and inhibitors related to angiogenesis. This array contains the growth factors, cytokines, and chemokines that promote the biogenesis of new blood vessels and the genes that encode inhibitors of this process. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the promotion and inhibition of angiogenesis with this array.血管生成因子与血管生成抑制因子RT Profiler PCR Array可以同时测定调节84个与血管生成相关的生长因子或抑制基因的表达谱。其中包括与促进或抑制新的血管生成相关的生长因子、细胞因子、趋化因子等。利用实时定量PCR，你可以方便并且可信地对与促进或抑制血管生成相关的基因进行同时检测。Angiogenic Growth Factors and Related Genes: Growth Factors: ECGF1, FGF1, FGF13, FGF2, FGFBP1, FIGF, GRN, GRP, HGF, KITLG, LEP, MDK, PDGFB, PDGFD, PGF, PROK1, TGFA, VEGFA.Cytokines and Chemokines: BMP2, CCL15, CCL2, CSF3, CXCL11, CXCL12, CXCL13, CXCL14, CXCL3, CXCL5, CXCL6, CXCL9, IL10, IL6, IL8, PPBP, PTN, TNF.Other Positive Regulators of Angiogenesis: AGGF1, AMOT, ANG, ANGPT1, BTG1, EDIL3, EREG, FST, RHOB, RUNX1.Angiogenesis Inhibitors and Related Genes:Cytokines, Chemokines and Growth Factors: CXCL10, CXCL2, IFNG, IL12A, IL12B, IL17F, PF4, TGFB1.Other Negative Regulators of Angiogenesis: ANGPT2, ANGPTL1, BAI1, CD55, CD59, CHGA, COL18A1, COL4A3, FN1, IFNA1, IFNB1, KLK3, MLLT7, NPPB, NPR1, PLG, PRL, RNH1, SERPINC1, SERPINE1, SERPINF1, SPINK5, STAB1, THBS1, TIE1, TIMP1, TIMP2, TIMP3, TNNI2, TNNI3. 血管生长因子及相关基因、血管生成抑制因子及相关基因Tumor Metastasis PCR Array肿瘤转移PCR芯片Catalog No. PAHS-028A（人）Catalog No. PAMM-028A（小鼠）The Tumor Metastasis RT Profiler PCR Array is designed to represent 84 genes known to be involved in metastasis. Genes selected for this array encode several classes of protein factors including cell adhesion, ECM components, cell cycle, cell growth and proliferation, apoptosis, transcription factors and regulators and other genes related to tumor metastasis. This array can help you investigate the molecular mechanism of metastasis or understand how a particular tumor metastasized. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to metastasis.肿瘤转移RT Profiler PCR Array可以同时检测已知的参与肿瘤转移的84个基因表达谱。本芯片所选的基因编码以下几类蛋白因子：细胞黏附，ECM成分，细胞周期，细胞生长和增殖，凋亡，转录因子和调节子以及其他一些转移相关因子。本芯片能够帮助研究者研究转移的分子机制或者了解一个特定的肿瘤转移过程。利用实时定量PCR，你可以方便并且可信地对与肿瘤转移相关的基因进行同时检测。Cell Adhesion Genes:Cell to Cell Adhesion: APC, CD44, CDH1 (cadherin-1 / E-cadherin), CDH11, CDH6, FAT, FXYD5, ITGA7, PNN, SYK, VEGF. Transmembrane Receptors: CD44, ITGA7, ITGB3, LAMR1. Other Genes Related to Adhesion: CTNNA1, FN1, MCAM, MGAT5 (acetylglucosaminyltransferase V), MTSS1. Extracellular Matrix Proteins:Matrix Metalloproteinases: MMP10, MMP11, MMP13, MMP2, MMP3, MMP7, MMP9. MMP Inhibitors: TIMP2, TIMP3, TIMP4. Other ECM Proteins: COL4A2 (collagen a2(IV), HPSE (heparanase). Cell Cycle Genes: Regulation of the Cell Cycle: HRAS, IL1B, KRAS, TGFB1(TGF-1), VEGF. Negative Regulation of the Cell Cycle: APC, BRMS1 (BrMS1), CDKN2A, MTSS1, NF2, NME1, NME2, PTEN, RB1, TP53. Cell Cycle Arrest and Checkpoint: CDKN2A, MYC (c-myc), RB1, TP53. Cell Growth and Proliferation Genes: Negative Regulation of Cell Proliferation: CDKN2A, CTBP1, GNRH1, IL1B, MDM2, NF2, NME1, NME2, SSTR2. Positive Regulation of Cell Proliferation: IGF1, IL18, TSHR, VEGF. Growth Factors and Hormones: GNRH1, HGF (Scatter Factor), IGF1, TGFB1 (TGF-1), VEGF. Cytokines and Chemokines: CCL7, CXCL12, IL18, IL1B, TNFSF10. Receptors: CXCR4, EPHB2, FGFR4, FLT4, GPR54, IL8RB, MET, NR4A3, PLAUR (uPAR), RORB, SSTR2, TSHR. Other Genes Related to Growth: DENR, EWSR1, HRAS (c-hRas), MYC (c-myc), SET, SRC (c-src), SYK, TRPM1. Apoptosis genes: Induction of Apoptosis: HTATIP2, IL18, TIMP3, TNFSF10, TP53. Anti-apoptosis: HTATIP2, TGFB1. Other Genes Related to Apoptosis: CXCR4, IL1B. Transcription Factors and Regulators: Transcription Factors: ETV4, HTATIP2, MTA1, MYC (c-myc), MYCL1, NME2, NR4A3, RB1, RORB, SMAD4, TCF20, TP53. Regulators: CHD4, EWSR1, SMAD2. Other Genes Related to Metastasis: CST7, CTSK, CTSL (cathepsin L), KAI1, KISS1 (KiSS-1), METAP2, NME4. 细胞黏附有关基因；细胞外基质蛋白分子；细胞周期相关基因；细胞生长和分化有关基因；细胞凋亡相关基因；转录因子及其调节因子；其他与肿瘤转移相关基因肿瘤发生机理PCR芯片癌通路发现者PCR芯片氧化应激与抗氧化PCR芯片DNA损伤信号通路PCR芯片应激与毒性通路发现者PCR芯片p53信号通路PCR芯片细胞损失应激反应PCR芯片Cancer PathwayFinder PCR Array癌通路发现者PCR芯片Catalog No. PAHS-033A（人）Catalog No. PAMM-033A（小鼠）Catalog No. PARN-033A（大鼠）The Cancer Drug Resistance & Metabolism RT Profiler PCR Array profiles the expression of 84 genes involved in the bodys response to chemotherapy. The genes encoding important enzymes for drug resistance (such as the P-glycoproteins), phase I metabolism (specifically the P450 family), and phase II metabolism (such as various covalent modification enzymes) are all represented on the array. Cancer-related genes involved in aspects of resistance are also included on the array such as DNA repair enzymes, cell cycle regulators, growth factor and hormone receptors, and transcription factors. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to cancer drug resistance and metabolism with this array.肿瘤信号通路发现者RT Profiler PCR Array可以同时测定84个与转化和肿瘤发生密切相关的代表性的六个信号通路有关的关键基因。使用此Array，你可以首先确定哪个信号通路在你的实验处理中被激活。你可以通过其他的信号通路特异性的PCR Array 来研究更为细节的基因表达谱。利用实时定量PCR，你可以方便并且可信地对与肿瘤发生相关的基因进行同时检测。Cell Cycle Control & DNA Damage Repair:ATM, BRCA1, CCNE1 (cyclin E1), CDC25A, CDK2, CDK4, CDKN1A (p21Waf1), CDKN2A (p16Ink4), CHEK2 (chk2 / Rad53), E2F1, MDM2, RB1, S100A4, TP53 (p53). Apoptosis and Cell Senescence:APAF1, BAD, BAX, BCL2, BCL2L1 (bcl-X), CASP8, CFLAR (CASPER), GZMA, HTATIP2, TERT (telomerase), TNFRSF1A (TNF- receptor), TNFRSF10B (DR5), TNFRSF25 (DR3). Signal Transduction Molecules and Transcription Factors:AKT1, ERBB2, ETS2, FOS, JUN, MAP2K1 (MEK), MYC,