化疗药物配制指南.doc

化疗药配备Common Antineoplastic Drug Pharmacy Preparation Chart Generic Name(INN)Trade NameConcentration /DiluentPrecautions /Stock SolutionStabilityVehicle forInfusionPrecautions /Ready-to-UseSolutionStabilityAmifostineEthyol500 mg in 9.7mL of 0.9% NaCl6 hrs (RT)24 hrs(refrigerated)n.r.Administerwithin 25 minutesAsparaginaseAsparaginase10,000 U in 4mL of WFIIn the dark,6 hrs)5% Dex / 0.9% NaClAzathioprineImurek50 mg in 5-15mL of WFI120 hrs (RTor refrigerated)0.9% NaCl or 0.18% NaCl + 4% DexAdminister after preparationBleomycinBleomycinNumerous incompatibilities0.9% NaClCarboplatinCarboplat50 mg in 5 mLIn the dark5% Dex / 0.9% NaCl Conc 0.5 mg/mL8 hrs (RT) 24 hrs (refrigerated)Carmustine(BCNU)CarmubrisDissolve in 3 mL of ethanol, add 27 mL of WFI100 mg in 30 mL5% Dex / 0.9% NaCl0.9% NaCl8 hrs (RT)24 hrs (refrigerated)CisplatinPlatinex50 mg in 100 mLIn the dark, RT0.9% NaCl8 hrs (RT)CladribineLeustatin10 mg in 10 mL0.9% NaClAdminister within 8 hrs (refrigerated)CyclophosphamideEndoxan1,000 mg in 50 mL of WFI24 hrs (refrigerated)5% Dex / 0.9% NaClCytarabineAlexan100 mg in 5 mL5% Dex / 0.9% NaClDacarbazine(DTIC)Detimedac100 mg in 10 mL of WFIIn the dark; prepare immediately before use5% Dex / 0.9% NaClAdminister within 30 minDactinomycinLyovac-CosmogenDissolve in 1.1 mL of WFI 0.5 mg in 1 mLIn the dark5% Dex / 0.9% NaClDaunorubicinDaunoblastin100 mg in 10 mL of WFIIn the dark, 24 hrs (RT), 48 hrs (refrigerated)DocetaxelTaxotere80 mg in 8 mLPrepare immediately before use5% Dex / 0.9% NaCl Conc 0.1 mg/mLAdminister after preparationFilgrastim(G-CSF)Neupogen300 g in 1 mLRefrigerated5% Dex. NO NaCl Conc 2 g/mL24 hrs (refrigerated)FludarabineFludara50 mg in 2 mL of WFI8 hrs5% Dex / 0.9% NaClFluorouracil(5-FU)Fluroblastin1,000 mg in 20 mLIn the dark, RT5% DexFolinic AcidCalcium SaltPentahydrateLeucovorin200 mg in 20 mLIn the dark0.9% NaClGemcitabineGemzar200 mg in 5 mL of NaCl24 hrs (RT);DO NOT REFRIGERATE0.9% NaClAdminister within 30 minIdarubicinZavedos10 mg in 10 mL of WFI24 hrs (refrigerated)N/A, bolusInject within 10-15 minIfosfamideHoloxan1,000 mg in 25 mL of WFI48 hrs (refrigerated)5% Dex / 0.9% NaClInterferonalfa-2aRoferon A3,000,000 U in 1 mLIn the dark, refrigeratedN/ASC or IMInterleukin-2ProleukinDissolve in 1.2 mL of WFI18,000,000 U in 1 mL24 hrs5% Dex + 0.1% HAAdminister after preparationm-AMSAAmsidyl1.5 mL of concentrate in 13.5 mL of soln (glass syringe) 75 mg in 15 mLIn the dark, 8 hrs5% Dex NO NaCl!Administer within 60-90 minMelphalanAlkeran50 mg in 10 mL of solution / diluentIn the dark, RT; prepare immediate-ly before use0.9% NaCl. No Dex!Administer within 90 minMethotrexateMethotrexate50 mg in 2 mLIn the dark5% Dex / 0.9% NaClMitomycin CMitomycin10 mg in 10 mL of WFIIn the dark; prepare immediately before use5% Dex / 0.9% NaCl3 hrs in 5% DexMitoxantroneNovantrone,Onkotrone20 mg in 10 mL7 days once opened5% Dex / 0.9% NaCl48 hrsNimustineACNU50 mg in 10 mL of WFIPrepare immediately before useN/AInject IV after preparationPaclitaxelTaxol30 mg in 5 mLIn the dark, RT5% Dex / 0.9% NaCl Conc 0.3-1.2 mg/mL27 hrs (RT);DO NOT REFRIGERATE!USE PVC-FREE GIVING SETS!PentostatinNipent10 mg in 5 mL of WFI8 hrs (RT)n.r.Administer IV or diluted within 20-30 minTeniposideVM 2650 mg in 5 mLIn the dark5% Dex / 0.9% NaCl Conc 0.1 mg/mL24 hrs (RT);O NOT REFRIGERATE!USE PVC-FREE GIVING SETS!ThiotepaThiotepa15 mg in 1.5 mL of WFIRefrigerate; prepare immediately before use5% Dex / 0.9% NaClTopotecanHycamtin4 mg in 4 mL of WFI12 hrs (RT),24 hrs (refrigerated)5% Dex / 0.9% NaCl Conc 25-50 g/mLTreosulfanOvastat1,000 mg in 20 mL of WFI8 hrsn.r.VinblastineVelbe10 mg in 10 mL of NaClPrepare immediately before useN/AInject IV within 1 minVincristineVincristine1 mg in 1 mLIn the dark, 14 days (refrigerated)5% Dex / 0.9% NaClVindesineEldisine5 mg in 5 mL30 days(refrigerated)N/AInject IVVinorelbineNavelbine10 mg in 1 mL of WFI5% Dex / 0.9% NaClAdminister within 6-10 min / 24 hrs (RT)Abbreviati