头孢克肟说明书.doc

(), ,;,;(,);,50mg20ml30:,50-100mg;200mg:,1.5-3.0mg12,879294(2.58%)112(0.87%)29(0.23%)gpt78(0.61%)got58(0.45%)26(0.20%)1(1)(0.1%)(2)()(0.1%)(3)(stevens-johnson0.1%)(lyell0.1%)(4)(0.1%)(0.1%)(0.1%)(5)(0.1%(6)(0.1%)(7)piexpie(0.1%)212()3(1)(2)()(3)(k)(4)(5)1(1)(benedict)(fehling)(clinitest)(2) ,(),(pbp)pbp1(la,lb,lc)pbp3-sd100-1000mg/kg320-3200mg/kgpdr57:,4050%,200mg,3.7g/ml,25%50%200mg400mg3g/ml4.6g/ml,100mg400mg,-10%25%,200mg400mg400mg26,200mg252450%65%,14,34,9,:aucs40%:2050ml/min,6.4;520ml/min,11.5:,400mg,2160ml/min20824h20040810 -150mg100mg200mg40.69g/ml1.18g/ml1.95g/mlt1/22.32.51.5mg/kg6.0mg/kg341.14g/ml2.01g/ml3.97g/mlt1/23.23.701220%25%50mg4642.9%30kg150100mg121200mg11.53mg/kg1216mg/kggptgot1benedictfehlingclintestcoomgx test)2123 cefixime capsules toubaokewo jiaonang ( 6r, 7r)-7-( z)-2-( 2-4-)-2-( )-8-3-5-1-4.2.0-2-2- c16h15n5o7s23h2o507.501. 2. 3. 4. 5. 150 mg 2100 mg 30100 mg2200 mg2 1.53.0 mg2 0.87%0.23%gpt0.61%got0.45%0.20% 1 0.1% 0.1% stevens-johnson0.1%lyell0.1% 0.1%0.1%0.1% 0.1% 0.1% piexpie0.1% 2 123 4 k5benedictfehlingclinitest 6 71000 mg/kg 400 6 auc26%20%60 ml?21?60 ml?75%?20 ml? 1. -pbppbp11a1b1cpbp3 2. 1ld2sd1003201000mg/kg/kg5sd1003201000mg/kg531000mg/kg1000mg/kg3sd1001000mg/kg3203200mg/kg 3.1000mg/kgsd560mg/kg2 4. 1. 150100900mg40.691.131.95?g/ml2.32.51.53.06.0mg/kg341.142.013.97g/ml3.23.7230ccr<60ml/minn=310ccr<30ml/minn=4100mg62.04?g/ml82.27?g/ml120.71?g/ml1.83?g/ml4.1511.05 2. 3. 4. 50100200m