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Lecture9TCMHerbsinTraditionallyDefinedPropertiesY Z ChenDepartmentofPharmacyNationalUniversityofSingaporeTel 65 6616 6877 Email phacyz nus edu sg Web http bidd nus edu sg ContentTCMherbsintraditionallydefinedpropertiesDigitizationofTCMherbsintraditionallydefinedpropertiesClassificationmethodsforidentifyingTCMrecipesTCMherbpairsTCMcombinationtherapy HerbProperty 1 FourCharacters 四性 2 FiveTaste 五味 3 Meridian 归经 4 Lifting lowering floatingandsinking 升降浮沉 TCMherbsintraditionallydefinedproperties 1 FourCharacters四性 Qi ThetemperatureCharacteristic ClinicPracticingTreatingcoldsyndromewithhot natureddrugs orheatingthecold Treatingheatsyndromewithcold natureddrugs orcoolingtheheat Identifythe Realcoldsyndromewithfakeheatsyndromes or Realheatsyndromeswithfakecoldsyndromes AccordingtothedevelopmentofdiseasetochooseproperherbsTreatingbothheat coldsymptomswithbothcold hotnatureddrugs TCMherbsintraditionallydefinedproperties 2 FiveTaste五味 TCMherbsintraditionallydefinedproperties 3 Meridian归经Herbagentstargetspecificchannelswithinthebodytoeffectachangeinthatchannel TCMherbsintraditionallydefinedproperties TCMherbsintraditionallydefinedproperties TCMherbsintraditionallydefinedproperties 4 lifting lowering floatingandsinking升降浮沉Varyingdiseaseoftenappeartobearatendencytomoveupward downward towardstheexteriorortheinterior Correspondingtotheabove thedirectionofactionsofmedicinalherbsonhumanbodyalsohavethelifting lowering floatingandsinkingdistinction TCMherbsintraditionallydefinedproperties TCMherbsintraditionallydefinedproperties TCMherbsintraditionallydefinedproperties DigitizationofTCMherbsintraditionallydefinedproperties DigitizationofTCMherbsintraditionallydefinedproperties DigitizationofTCMherbsintraditionallydefinedproperties DigitizationofTCMherbsintraditionallydefinedproperties GeometricPictureofDigitalRepresentation A 1 1 1 B 0 1 1 C 1 1 1 D 0 1 1 E 0 0 0 F 1 0 1 GeometricPictureofDigitalRepresentation Featurevectorsininputspace A 1 1 1 B 0 1 1 C 1 1 1 D 0 1 1 E 0 0 0 F 1 0 1 Featurevector ClassificationmethodsforidentifyingTCMrecipes kNNmethod ClassificationmethodsforidentifyingTCMrecipes SupportVectorMachines SVM method ClassificationmethodsforidentifyingTCMrecipes SupportVectorMachines SVM method ClassificationmethodsforidentifyingTCMrecipes ClassificationmethodsforidentifyingTCMrecipes CompatibilityofTCMHerbPairs 1 Mutualreinforcement 相须 2 Mutualassistance 相使 3 Mutualrestraintordetoxication 相畏or相杀 4 MutualAntagonism 相恶 5 MutualIncompatibility 相反 TCMHerbPairs 1 Mutualreinforcement 相须 Thatis twoormoreingredientswithsimilarpropertiesandeffectsareusedincombinationtoreinforceeachother saction TCMHerbPairs 2 Mutualassistance 相使 Thatis Chinesemedicinalherbsthatarenotcertainlysimilarbuthavesomerelationshipintheaspectofmedicinalpropertiesandactionsareusedincombination inwhichoneherbistakenasthedominatefactorandtheothersasitsassistantstoraiseitstherapeuticeffects TCMHerbPairs 3 Mutualrestraintordetoxification 相畏or相杀 Thatis mutualrestrainingeffectofdifferentmedicinestoweakenorneutralizeeachother sharmfulness suchastoxicityorside effects TCMHerbPairs MutualAntagonism 相恶 Theabilityoftwosubstancestominimizeorneutralizeeachother spositiveeffects TCMHerbPairs MutualIncompatibility 相反 Causesideeffectsortoxicityifusetogether TCMHerbPairs TCMHerbPairs TCMHerbPairs TCMHerbPairs TCMherbalingredientpairsdisplayingpharmacokineticsynergismByinhibitingtheactionsofthedrugeffluxtransporters resultinginanaccumulationoftheTCMherbalingredientsandthusapotentiationoftheireffectsinthetargetcells Anexampleisthecombinationofgenistein fromSemenSojaePraeparata OleumGlycines RadixSophoraeJaponiae FlosSophorae FructusSophorae FoliumSophoraeJaponiae SemenGlycinesMax CaulisSpatholobi RadixSophoraeTonkinensis andpaclitaxel fromTaxusChinensis TCMHerbPairs Mechanismofsynergisticactionsofpaclitaxelandgenistein TCMHerbPairs TCMherbalingredientpairsdisplayingpharmacokineticsynergismBymodulatingitsmetabolism resultinginanaccumulationoftheTCMherbalingredientandthusapotentiationoftheireffectsinthetargetcells AnexampleisthecombinationofTCMherbalingredientpaircomprisingofcaffeine fromRadixCamelliaSinensis FoliumCamelliaeSinensis FructusCamelliaSinensis FoliumIlicisCornutae CortexFirmianaePlantanifoliae RadixFirmianaePlantanifoliae FlosFirmianaePlantanifoliae FoliumFirmianaePlantanifoliae SemenFirmianae andapigenin fromHerbaLagotidis FlosCampsis HerbaArtemisiaeAnomalae HerbaEphedrae FlosBuddlejae HerbaArtemisiaeAnomalae FlosGenkwa RadixseuCortexDaphnesGenkwae RadixCampsisGrandiflorae TCMHerbPairs Mechanismofsynergisticactionsofcaffeineandapigenin TCMHerbPairs TCMherbalingredientpairsdisplayingpharmacodynamicsynergismThecombinationofeugenol fromFructusArtemisiaeArgyi FoliumArtemisiaeArgyi CaulisPerillaeFrutescentis FoliumPerillaeFrutescentis DianthusSuperbus FructusPerillaePreparata AlpiniaGalangae FlosCaryophylli RadixSyzygiiAromatic LiquorDestillataCaryophylli CortexSyzygiiAromatic RamulusSyzygiiAromatic FructusGalangae PericarpiumZanthoxyli FlosLonicerae HerbaAsari andlowconcentrationofquercetin fromHerbaPatriniaeScabiosaefoliae HerbaPatriniae RadixBupleuri HerbaEuphorbiaeHumifusae RadixLamiophlomidisRotatae RhizomaAlpiniaeOfficinarum HerbaHyperici HerbaLagotidis CannabisSativaL TCMHerbPairs TCMherbalingredientpairsdisplayingpharmacodynamicsynergismRadixAstragali FructusLigustriLucidi HerbaArtemisiaeAnnuae RadixArtemiiaeAnnua SemenArtemisiae HerbaTaxilli FructusQuisqualis RadixQuisqualisIndica HerbaPyrolaeChinensis HerbaEphedrae exertsananti allergicandanti inflammatoryeffectthatalleviatesallergicrhinitis whichiscongruoustothetherapeuticeffectoftheTCMherbalpair HerbaAsariandHerbaEphedrae containingeugenolandquercetinrespectively ThisTCMherbalpairhasbeenusedtotreatallergicrhinitis ThesimilarityintherapeuticeffectoftheTCMherbalingredientpairandtheTCMherbalpaircanbeasignofpossiblesynergismbetweentheingredientsintheTCMherbalingredientpair TCMHerbPairs Mechanismofsynergisticactionsofeugenolandquercetin lowconcentration TCMCombinationTherapy Casestudy1 AntidepressantactivityofSt John sWortSt John sWort SJW isanextractfromtheplantHypericumperforatumL NumerousclinicaltrialshaveshownthatSJWhadsignificantantidepressantefficacyandlowersideeffectsthanstandardantidepressants Inmanycountries ithasbeenwidelyusedforthetreatmentofmildtomoderateformsofdepression SJWhasbeenincludedinthepharmacopoeiasofGermanyandtheUS ThemainactiveingredientsofSJWarehyperforin HP hypericin HY pseudohypericin PH amentoflavone AF andseveralflavonoids FL Casestudy1 AntidepressantactivityofSt John sWort TCMCombinationTherapy Casestudy1 AntidepressantactivityofSt John sWort TCMCombinationTherapy TCMCombinationTherapy Casestudy2 TheeffectofRealgar Indigonaturalisformula RIF onacutepromyelocyticleukemia APL TCMformulaRIFhasbeenusedinChinatotreatAPLsince1980s RIFconsistsoffourherbs realgar Indigonaturalis Salviamiltiorrhiza andRadixpseudostellariae InTCMtheory multipleagentscontainedinoneformulamustworksynergistically RealgarisregardedastheprincipalcomponentoftheformulaRIF andtheotherthreeareadjuvantcomponentstoassisttheeffectofrealgar Themainactivecompoundsofrealgar IndigonaturalisandSalviamiltiorrhizaaretetraarsenictetrasulfide As4S4 A indirubin I andtanshinoneIIA T respectively TCMCombinationTherapy Casestudy2 TheeffectofRealgar Indigonaturalisformula RIF onacutepromyelocyticleukemia APL A Proteininteractionnetwork B Protein pathwayassociationnetwork TCMCombinationTherapy Casestudy2 TheeffectofRealgar Indigonaturalisformula RIF onacutepromyelocyticleukemia APL TCMCombinationTherapy ComparisonwithcombinationtherapyinWesternmedicine TCMCombinationTherapy ComparisonwithcombinationtherapyinWesternmedicine TCMCombinationTherapy ComparisonwithcombinationtherapyinWesternmedicine TCMCombinationThera

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