阿德福韦抗乙肝病毒感染治疗的数学模型及疗效预测费.pdf

1 100083 New England J Med 2005 6 Adefovir dipivoxil 180 HBeAg CHB Nowak HBV 1 Hepatitis B 1 World Health Organization WHO 20 Hepatitis B surface antigen HBsAG 3 7 1 3 2 25 40 1 3 67 3000 500 2 3 HBV 4 CHB interferon lamivudine adefovir 5 Adefovir dipivoxil 180 HBeAg CHB HBV DNA HBV DNA 1996 Nowak 3 6 1 Nos 60074034 70271068 No 20020008004 1 Nowak HBV 7 HBV HBV 4 5 2 HBeAg CHV 1996 Nowak dx dt dx bvx dy dt bvx ay dv dt ky uv 1 x y v dx b ay ky uv a b k u CHV HBV dx dt dx bvx dy dt bvx a k1 y pye dv dt k k2 y u k3 v de dt k4y k5ve 2 HBV 6 dx dt dx bvx dy dt bvx ay dv dt ky uv de dt k5ve 3 x y v e dx b ay ky uv k4y k is p 2 084168252336420504588672 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 Plasma virus HBV DNA copies per ml Time days Treatment Follow up Treatment Follow up 1 48 2 48 HBV DNA CHV HBV DNA 1000 ml 3 1 48 2 48 HBV DNA HBV DNA 2 3 d b a p k u k1 k2 k3 k4 k5 2 4e 5 3 6e 3 3 9604e 11 3 61e 3 4e 7 3 03e 1 2e 1 0 3 0294e 1 1 8e 5 1e 8 4 d b a p k u k5 4 6210e 5 2 4e 5 3 6e 3 3 9604e 11 3 61e 3 4e 7 3 03e 1 2e 1 1e 8 HBeAg CHV HBV DNA 1 HBV DNA 48 336 96 672 1000 ml 4 2 336 672 2 96 672 HBV DNA 4 ml HBV DNA 1 4 5 4 HBV HBV HBV 3 084168252336420504588672 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 Plasma virus HBV DNA copies per ml Time days Treatment Follow up 2 48 2 48 HBV DNA CHV HBV DNA CHV 96 672 HBV DNA 4 5 HBV HBV HBV HBV HBV HBV 1 Maddrey W C Hepatitis B an important public health issue Clin Lab 47 51 59 2001 2 7 1 59 61 2004 3 10 2 349 1997 4 2003 12 15 htpp disparticle asp classid 3 id 15 5 Stephanos J Hadziyannis M D Nicolaos C et al Long time therapy with adefovior dipivoxil for HBeAg Negative chronic hepatitis B New england Journal of Medicine 352 26 2673 2681 2005 6 Nowak M J Bonhoeff er S Hill A M et al Viral dynamics in hepatitis B virus infection Proc Natl Acad Sci USA 93 4398 402 1996 7 Lequan Min Xisong Dong Research on viral dynamic models