电化学活性的化合物.doc

具有电化学活性的化合物参考表 具有电化学活性的基团举例可氧化的l 酚l 芳香胺l 杂环胺l 单胺l 硝基胺可还原的l 醛l 醌l 硫氰酸根l 重氮化合物l 亚硝基化合物可氧化的化合物举例下面是一个假想的化合物，说明具有电化学活性的各种官能团。具有电化学活性的化合物是芳香族化合物，或含有羟基，甲氧基或胺等官能团。脂肪族化合物，如硫醇（类）和胺类也具有电化学活性。某些化合物例如：碳水化合物，需要特殊的检测方式，称之为脉冲安培检测法或简称PAD. 1) OXIDATION ON CARBON WORKING ELECTRODE. DC MODE2) REDUCTION ON CARBON WORKING ELECTRODE. DC MODE3) OXIDATION ON CARBON WORKING ELECTRODE FOLLOWING DERIVATIZATION 4) OXIDATION ON MERCURY OR MERCURY/GOLD AMALGAM. DC MODE5) OXIDATION ON GOLD WORKING ELECTRODE. PAD MODE许多化合物具有电化学活性，可以用HPLC-ECD（带电化学检测器的高压液相）进行检测。 以下所列的是各种具有电化学活性的化合物，这是基于他们的化学结构或引自科学文献。所列化合物仅供参考，并非暗示可从ESA公司获得所有这些化合物的分析方法。氨基酸类AMINO ACIDS ( e.g. brain, plasma, CSF, microdialysis) Underivatized Derivatized Methionine 蛋氨酸，甲硫氨酸 with OPA/ME Tryptophan 色氨酸 Tyrosine 酪氨酸 alpha-AMINO BUTYRIC ACID 丁酸 Alanine 丙胺酸 Arginine 精氨酸 Aspartic acid天（门）冬氨酸 Asparagine 天冬酰胺酸 -alanine -丙胺酸 -amino butyric acid -氨基丁酸 (carnosine)肌肽 citrulline瓜氨酸 Cysteine (cystine) 半光胺酸 gamma-amino butyric acid Glutamic acid g-氨基丁酸 Glutamine 谷氨酸盐 Glycine 氨基乙酸 Histamine 组胺 Histidine 组胺酸 Isoleucine异亮安酸 Leucine 亮氨酸 Lysine 赖氨酸 Methionine蛋氨酸，甲硫氨酸 Nitro-arginine Nitro-精氨酸 Phenylalanine 苯基丙氨酸 Phospho-ethanolamine Serine丝氨酸 Taurine Threonine苏氨酸 Tryptophan 色氨酸 Tyrosine酪氨酸 Valine Derivatized Miscellaneous with NBD Chloride Di-peptides (wide variety containing trp, tyr or met)Hydroxy-proline羟基脯氨酸Homocarnosine Proline 脯氨酸N-acetyl-histidineN-乙酰基组氨酸1-methyl histidine 1-甲基组氨酸3-methyl histidine 3-甲基组氨酸3-nitro tyrosine 3-硝基酪氨酸3,3,5 tri-iodothyronineThyroxine 甲状腺素Tri-peptides (wide variety containing trp, tyr or met) 抗氧化剂ANTIOXIDANTS t-butylhydroquinone4,6-di-t-butyl-3-cresolt-butyl-4-hydroxy-5-methylphenylsulfide2,6-di-t-butyl-4-ethylphenolt-butylhydroxyanisole3,5-di-t-butylhydroxyanisole3-t-butyl-4-hydroxy-5-methylphenylsulfide2,5-di-t-butylhydroquinonebutylhydroxytoluene2,6-di-t-butyl-4-hydroxymethylphenol2-t-butyl-4-methylphenol2,6-di-t-butyl-4-methylphenol2-t-butyl-6-methylphenol2,6-di-t-butylphenol4-t-butyl-2-methylphenol2,4-di-t-butylphenol2-t-butyl-5-methylphenol3,5-di-t-butylphenol3-t-butyl-5-methylcatechol2,6-di-s-butylphenol5-t-butyl-3-methylcatechol4,6-di-t-butylresorcinol2-s-butylphenol2,2-methylenebis (6-t-butyl-4-cresol)4-s-butylphenol4,4-methylenebis (6-t-butyl-4-cresol)2-t-butylphenol4,4-thio-bis (6-t-butyl-2-cresol)3-t-butylphenol2,4,6-tri-t-butylphenol4-t-butylphenoldodecyl gallate2,6-di-t-butyl-3-dimethylamino-p-cresolnonyl gallate2,6-di-t-butyl-4-benzoquinoneoctyl gallate2,6-di-butyl-4-n-butylphenolpropyl gallate3,5-di-t-butylcatechol2,6-di-t-butyl-4-cresol CHLORINATED ANILINES 112-chloroaniline3-chloroaniline4-chloroaniline2,3-dichloroaniline2,4-dichloroaniline2,5-dichloroaniline2,6-dichloroaniline3,4-dichloroaniline 3,5-dichloroaniline2,3,4-trichloroaniline2,4,5-trichloroaniline2,4,6-trichloroaniline2,3,4,5-tetrachloroaniline2,3,5,6-tetrachloroanilinePentachloroanilineCHLORINATED NAPHTHOLS 4-chloronaphthol 2,4-dichloronaphthol CHLORINATED PHENOLS2-chlorophenol3-chlorophenol4-chlorophenol2,3-dichlorophenol2,4-dichlorophenol2,5-dichlorophenol2,6-dichlorophenol3,4-dichlorophenol3,5-dichlorophenol2,3,4-trichlorophenol2,3,5-trichlorophenol 2,3,6-trichlorophenol2,4,5-trichlorophenol2,4,6-trichlorophenol3,4,5-trichlorophenol2,3,4,5-tetrachlorophenol2,3,4,6-tetrachlorophenol2,3,5,6-tetrachlorophenolpentachlorophenol3,5-dimethylphenol2,3,6-trimethylphenol2,3,5-trimethylphenol2,3,5-trimethylphenolDNA加合物DNA ADDUCTS 3-methyl Guanine8-nitro Guanine7-methyl Guanine8-hydroxy-2-deoxyguanosineO-6-methyl Guanine8-hydroxyguanosineGN methyl Guanine5-oxocytidineGR methyl Guanine 药DRUGS (microdialysis, plasma extracts)1-Phenylethylamine10-Hydroxyamitriptyline10-Hydroxyimipramine10-Hydroxynortriptyline11-Hydroxyclomipramine2-Hydroxydesipramine2-Hydroxymipramine2-Phenylethylamine3-Monoacetylmorphine4-Hydroxypropranolol6-MonoacetylmorphineAcebutololAcepromazineAcetamide 乙酰胺AcetophenazineAcetorphineN-Acetylproccainamide (NAPA)AdiphenineAjmalineAllylprodineAlphacetylmethadolAlphameprodineAlphamethadolAlphaprodineAlprenololAlverineAmilorideAminopromazineAmoxicillinAmthocaineAmidopyrineAmiodaroneAmitriptylineAmotripheneAnileridineAntazolineApomorphine阿朴吗啡AtenololAtropine 阿托品AzacyuclonalBamethaneBenactyzine苯乃静(一种安定药)BenperidolBenzethidineBenzhexolBenzocaineBenzoylecgonineBenzphetamineBenzquinamideBenztropineBenzylmorphineBenzylpenicillin卞青霉素BetacetylmethadolBetahistineBetameprodineBetamethadolBetaprodineBezitramideBromhexineBromodiphenhydramine溴苯海拉明（抗组胺药）BromperidolBrompheniramineBrompromazineBrucineBuclizineBufotenine蟾毒色胺BephenineBupivacaineBuprenorphineButacaineButaperazineButethamateButriptylineCarbenicillinCarbinoxamineCarphenazineCephalineChlorcyclizineChloropyrilineChloroquine 氯喹(治疟疾)ChlorpheniramineChlorphenoxamineChlorprenalineChlorproethazineChlropromazineChlroprothixeneCimetidineCinchocaineCinchonidine 金鸡纳啶CinnarizineClemastineClemizoleClomipramineClonidineCocaine 古柯碱,可卡因Codeine 可待因(自鸦片中提取的碱质)CyclazocineCyclizineCyclopentamineCyclopentolateCyproheptadineCyrenorphineDebrisoquineDeptropineDesacetylthymoxamineDesacetylvinblastineDesalkyldisopyramideDeserpidineDesethlamiodaroneDesipramineDesmthyldesipramineDesomorphineDextromthorphanDextromoramideDextropropxypheneDextrorphanDiapromideDibenzepinDiethazineDiethylpropionDiethylstilbestrolDienostrolDiethylthiambuteneDigydrocodeineDihydrocodeinoneDihydroergotamineDihydromorphineDimenoxadoleDimethyindeneDimethisoquinDimethothiazineDimethoxanateDimethylthiambuteneDioxaphetyl butyrateDiphenhydramineDiphenoxylateDiphenoxylic acidDiphenlpyralineDipipanoneDiprenorphineDipyridamoleDisopyramideDopamine多巴胺(一种治脑神经病的药物)DothiepinDothiepin 5-oxideDoxapramDoxepin多虑平，凯舒（一种抗抑郁药）Doxylamine抗敏安DroperidolEmbramineEmetine依米丁,吐根碱,吐根素(用作催吐剂等)Ephedrine 麻黄碱,麻黄素ErgocornineErgocristineErgocristinineErgocryptineErgometrine麦角新碱(用于催产和缓解偏头痛)ErgosineErgosinineErgotamine 麦角胺(主要用于治偏头痛和防止产后大出血)Estrone 雌激素酮EtafedrineEtamiphyllineEthinyloestradiolEthoheptazineEthopropazineEthylmorphineEtonitazeneEtorphineEtoxeridineFencamfaminFenethazineFenfluramine（抑制食欲以治肥胖的）氟苯丙胺FenoterolFentanylFlavoxateFluopromazineFlupenthixolFlupenthixol 5-oxideFluphenazineFlurazepamGlycopyrroniumHaloperidolHalopyramineHarmineHerionHexoestrolHistapyrrodineHomatropineHydrastinine白毛莨分碱HydrochlorothiazideHydrocodoneHydromorphinolHydromorphoneHydroxypethidineHydroxyzineHyoscineHyoscyamineIbogaineImipramineImipramine N-oxideIndapamineIndole 吲哚IprindoleIsolysergideIsomethadoneIsothpendylIsoxsuprineKetanserinKetobemidoneLabetalolLaudanosineLevallorphanLevomepromazeneLevomethorphanAmylocaineBenzocaineTetracaineLidocainePhenacetin乙酰对氨苯乙醚,非那西汀(解热镇痛剂的一种)ParacetamolSalicylamideAmitriptyleneProtriptyleneNortriptylineCarbamazepineImipramine DesipramineTripramineOpipramineSulphacetamideSulphadiazineSulphaguanidineSulphamerrazineSulphathiazolLevorphanolLidoflazineLignocaine利诺卡因,二乙氨基(麻醉用)LofepramineLorcainideLoxapineLysergamideLysergic acid 麦角酸Lysergide (LSD)LysergolMaprotilineMebanazineMebeverineMebhydrolinMecamylamineMeclophenoxateMeclozineMedazepamMephentermineMepivacaineMeptazinolMepyramineMequitazineMescaline酶斯卡灵(一种致幻剂)MesoridazineMetacillinMetaraminolMetazocineMethadoneMethapyrilineMethdilazineMethizineMethoserpidineMethotrimeprazineMethoxamineMethoxyphenamineMethoxypromazineMethlamphetamineMethyldesorphineMethylephendrineMethylergometrineMethylphenidateMethylsergideMetoclopramideMetopimazineMetoprololMianserinMonoethylglycinexylidide (MEGX)MorazoneMorpheridineMorphine N-oxideMorphine 吗啡MyrophineNadololNalorphineNaloxoneNaphazolineNarceine 罂粟碱NefopamNialamideNicocodineNicotine 烟碱NifedipineNomifensineNorbutriptylineNorchlorpromazineNorchlomipramineNorcodeineNorcyclizineNordextropropoxypheneNordothiepinNordotheipin 5-oxideNordoxepinNorphenfluramineNormianserinNormorphineNororphenadrineNorpethidineNortrimipramineNortriptylineNorverapamilNorzimelidineNoscapineOpipramolOrphenadrineOxacillinOxeladinOxomemazineOxprenololOxycodoneOxymetazolinOxymorphoneOxypertinep-Chlorodisopyramide (CDP)PapaverinePargylinePecazinePenbutololPentazocinePenthienatePerazinePerhexilinePerphenazinePethidinePethidinic acidPhenadoxonePhenampromidePhenazocinePhenbutrazatePhencyclidinePhendimetrazinePhenelzinePhenglutamidePhenindaminePheniraminePhenmetrazinePhenomorphanPhenoperidinePhenothiazinePhenolxybenzaminePhentolaminePhenylephrinePhenltoloxaminePholcodeinePhysostigminePiminnodinePimozidePindololPipamazinePipazethatePiperacetazinePiperidolatePipradrolPirbuterolPirenzepinePitramidePizotifenPractololPrajmaliumPramoxinePrazosinPrenylaminePrilocainePrimaquineProadifenProcainamideProcaine普鲁卡因(一种局部麻醉药)ProchlorperazineProcyclidineProheptazineProlintanePromazinePromethazinePronethalolPropanololProperadinePropiomazinePropranololProthipendylProtokylolProtriptylineProxymetacainePseudoephedrinePsilocinPyrimethanePyrrobutamineQuinidine奎纳定Quinine奎宁RanitidineReproterolRescinnamine萝芙木碱,抗高血压剂SalbutamolSotalolStrychnine 番木鳖碱(用于中枢神经刺激剂)SulphanilamideSulphapyridineTacrineTerazosinTerbutalineTerfenadineThebaconThebaineThenalidineThenyldiamineTheophyllineThiethylperazineThiopropazateThioproperazineThioridazineThiothixeneThonzylamineThymoxamineTigloidineTimololTocainideTofenacinTolpropamineTolycaineTramazolineTranylcypromineTrazodoneTriamterenTrifluoperazineTrifluperidolTrimeperidineTrimeprazineTrimetazidineTrimethyobenzamideTrimethoprim三甲氧苄胺嘧啶TrimipramineTripelennamineTriprolidineTryptamineTyramineVerapamilViloxazineVinblastineVincristineXylometazolineZimelidine 黄酮类和酚类FLAVONOIDS AND PHENOLICS (e.g. fruit juice, tea, urine)4-amino benzoic acid4-hydroxy benzoic acid4-hydroxy coumaric acid7-methoxy coumarin(apigenin)(baicalein)Caffeic acidCatechin(centaurein)Chlorogenic acidDaidzein黄豆苷原,羟基异黄酮(datiscetin)(diosmetin)Epicatechin gallateEpigallocatechinEpigallocatechin gallateEugenol丁子香酚(eupatorin)Ferulic acid(fisetin)(galangin)Gallic acid五倍子酸,没食子酸(gardenin)genisteinGentisic acid Hesperidin (irigenin)Kaempferol(leucoyanidin)(luteolin)毛地黄黄酮(mangostin)(morin)MyricetinNaringinNarirutin(pelargondin)(peonidin)(phloretin)(pratensein)Protocatechuic acid(rhamnetin)Quercetin栎精(sakuranetin)(scutellarein)ScopoletinSyringaldehydeSyringic acidTangeritin(troxerutin)UmbelliferoneVanillic acid GENERAL BIOCHEMICALS (e.g. brain tissue homogenates)Ascorbic acid抗坏血酸维生素CN-acetyl serotonin3,4-dihydroxy-benzylamine3,4-dihydroxy-mandelic acid (DOMA)3,4-dihydroxy-phenylacetic acid (DOPAC)3,4-dihydroxy-phenylalanine (L-DOPA)3,4-dihydroxy-phenylglycol (DHPG)3-hydroxy-anthranilic acid2-hydroxy-phenylacetic acid (2HPAC)4-hydroxy-benzoic acid (4HBAC)8-hydroxy-2-deoxyguanosine 5-hydroxy indole-3-acetic acid (5HIAA)3-hydroxy-kynurenine3-hydroxy-mandelic acid3-hydroxy-4-methoxyphenylethylamine 4-hydroxy-phenylacetic acid (4HPAC)4-hydroxy-phenyllactic acid (4HPLA)5-hydroxy-tryptophan (5HTP)5羟基色氨酸5-hydroxy-tryptophol (5HTOL)5-hydroxy-tryptamine (5HT)5-hydroxy-tryptamine sulfate3-methoxy-4-hydroxy phenylglycol (MHPG)5-methoxy-tryptamine5-methoxy-tryptophan5-methoxy-tryptophol 3-methoxy-tyramine (3MT)3-methoxy-tyrosine (3-OM-DOPA)5-methyl-cysteine 3-methyl-guanine 7-methyl-guanine Anthranilic acid Bufotenine Dopamine Dopamine-3-glucuronideDopamine-3-sulfateDopamine-4-sulfate 多巴胺-4-硫酸盐Epinephrine肾上腺素EpinineFolic acid 叶酸, 维生素BGlutathione (reduced) 麸胺基硫(还原态)Glutathione (oxidized) 麸胺基硫(氧化态)Guanine GuanosineHomogentisic acid (hga)尿黑酸: 二羟苯醋酸Homovanillic acid (hva)香草酸Homovanillyl alcohol (hvol)Homoveratic acidHva-sulfateHypoxanthine次黄嘌呤Indole吲哚Indole-3-acetic acidIndole-3-lactic acidKynurenineMelatonin抗黑变激素MetanephrineN-methyl-tryptamineN-methyl-tyramineN,N-dimethyl-tryptamineN,N-dimethyl-tyramineNorepinephrine去甲肾上腺素NormetanephrineOctopaminePyridoxalPyridoxal-phosphatePyridoxamineSynephrineTryptopholTryptamineTyramineUric acid尿酸Vanillylmandelic acid (vma)香草扁桃酸Xanthine黄嘌呤Xanthosine 2,3-dihydroxybenzoic acid2,4-dihydroxybenzoic acid3,4-dihydroxybenzoic acid6-hydroxydopamine3,4-dihydroxyphenylacetaldehydeL-threo-3,4-dihydroxyphenylserineParbanic acid 除草剂和苯酚HERBICIDES AND PHENOLS Phenol苯酚o-cresol o-甲酚Pyrogallol2-nitrophenol 2-硝基酚4-nitrophenol 4-硝基酚2,4-dinitrophenol 2,4-二硝基酚4,6-dinitrocresol3-methyl-2-nitrophenol2,4-dichlorophenol2,6-dichlorophenol2,4,5-trichlorophenol4-chloro-3-methylphenol5-methylphenol4-methyl-2-nitrophenol2-hydroxyaniline4-hydroxyaniline1,2-phenylenediamine BenzocatechinButuronChlortholuronDiuronIsoproturonLinuronMethobromuronMetoxuronMonolinuronMonuron 对苯二酚及结合物HYDROQUINONE CONJUGATES (urine, bile) 2-(glutathion-s-yl) hydroquinone2,3-(diglutathion-s-yl) hydroquinone2,5-(diglutathion-s-yl) hydroquinone2,6-(diglutathion-s-yl) hydroquinone2,3,5-(triglutathion-s-yl) hydroquinone2,3,5,6-(tetraglutathion-s-yl) hydroquinone2-(cystein-s-yl) hydroquinone2,3,5-(tri-cystein-s-yl) hydroquinone2-(n-acetylcystein-s-yl) hydroquinone2-(cystein-s-yl glycine) hydroquinone 2-bromo-3-(glutathion-s-yl) hydroquinone2-bromo-5-(glutathion-s-yl) hydroquinone2-bromo-6-(glutathion-s-yl) hydroquinone2-bromo-3,5-(dicystein-s-yl) hydroquinone2-bromo-5-(cystein-s-yl) hydroquinone2-bromo-6-(cystein-s-yl) hydroquinone2-bromo-3-(n-acetylcystein-s-yl) hydroquinone2-bromo-5-(n-acetylcystein-s-yl) hydroquinone2-bromo-6-(n-acetylcystein-s-yl) hydroquinone2-bromo-3,5-(di-n-acetylcystein-s-yl) hydroquinone 羟基化联苯HYDROXYLATED BIPHENYLS 2-biphenylol3-biphenylol2,2-biphenyldiol3,3-biphenyldiol 4,4-biphenyldiol2,5-biphenyldiol3,4-diphenyldiol 神经毒素(微透析)NEUROTOXINS (microdialysis)1,3-dimethyl-tetrahydroisoquinoline6-hydroxydopamineR-salsolinolN methyl-R-salsolinol Tetrahydroisoquinolines5,6-dihydroxytryptamine5,7-dihydroxytryptamine 多氯联苯代谢产物PCB METABOLITES 2-chloro-4-biphenylol3-chloro-2-biphenylol3-chloro-4-biphenylol4-chloro-4-biphenylol5-chloro-2-biphenylol2-chloro-5-biphenylol2,5-dichloro-2-biphenylol2,5-dichloro-4-biphenylol2,5-dichloro-3-biphenylol3,5-dichloro-2-biphenylol3,5-dichloro-4-biphenylol4,4-dichloro-3-biphenylol4,4-dichloro-3,3-biphenylol 3,4-dichloro-4-biphenylol2,2,5-trichloro-5-biphenylol2,25-trichloro-4-biphenylol2,3,5-trichloro-2-biphenylol2,4,6-trichloro-4-biphenylol2