透皮吸收贴剂,透皮给药系统2016

,透皮递药系统Transdermal Drug Delivery System(TDDS),经皮给药系统（ transdermal drug delivery system, TDDS ）是指经皮肤敷贴方式给药，应用药剂学、物理学或化学方法及手段，促进药物穿过皮肤，由毛细血管吸收进入体循环并达到有效血药浓度，实现疾病治疗或预防的给药技术。,经皮给药系统TDDS,常用的剂型为贴剂(patch)，还有软膏剂、硬膏剂、涂剂和气雾剂等,国际上：东莨菪碱、硝酸甘油、雌二醇、芬太尼、烟碱、可乐定、 睾酮、硝酸异山梨酯、左炔诺酮等,国内 ：东莨菪碱、硝酸甘油、雌二醇、芬太尼、可乐定等,目前上市的药物,皮肤自外向内分为表皮、真皮和皮下组织三部分,药物通过皮肤的途径,1 Transdermal delivery of clonidine,Figure 1. Schematic of transdermal patch system of clonidine.,妥瑞综合症,阿片类药物戒毒,Figure 2. Schematic of future transdermal patch system.,Figure 3. Schematic of modified PermeGear In-Line diffusion cell for transdermal flux analysis,Figure 4. A representative permeation profile of clonidine through CNT membrane and skin after application of different bias sequences.,2 Transdermal delivery of siRNA,皮肤病,(A) The size of the microneedle array patch,(B) Configuration of the microneedle array patch and (C) Structure of a single microneedle model.,Delivery of siRNA strongly inhibits targeted Gapdh gene expression. *P 0.05, t test.,TDDS Work on the whole body,What is Rotigotine（罗替戈汀）,多巴胺受体激动剂早期或晚期帕金森罗替戈汀透皮系贴剂/Neupro,多巴胺 罗替戈汀,NEUPRO,第一个被允许上市的治疗帕金森的透皮贴剂（2007）Neupro贴剂采用硅酮作为基质治疗不宁腿综合症（2008）,European Journal of Pharmaceutics and Biopharmaceutics, Volume 88, Issue 3, November 2014, Pages 586-593,NEUPRO,Properties of the rotigotine transdermal system,Neurologic Clinics.Volume 31, Issu