肝细胞癌中的表达 南京医科大学

1,TheClinicalSignificanceofNuclearYAPExpressioninHepatocellularCarcinoma,徐智南京医科大学附属南京第一医院暨南京市第一医院肿瘤内科,WorldwideincidenceofHCC,BlumHE,SpangenbergHC.ArchIranMed.2007Jul;10(3):361-71.,IdentificationofYes-associatedProtein(YAP),Zender,L.etal.Cell125,1253-67,E,F,G,H,YAPimprovescellproliferation,Time(Days),*：p0.05。,YAPinducesanchorage-independentgrowth,MIHA-YAPcellsbutnotMIHA-Veccouldformcoloniesinsoft-agar.,MIHA-YAPcellsgainedadvantagesincellmigrationandinvasion.,YAPenhancescellularmobilityandinvasiveness,IHCresultsofYAPinHCC,53.7%HCCsamplesshowednuclearYAPpositive.,ClinicalassociationofnuclearYAPinHCC,ClinicalassociationofnuclearYAPandHCC-specificpostsurgicalrecurrence,Kaplan-Meier,MedianRFT：NuclearYAPnegative:25.8monthsvs.NuclearYAPpositive：12.9months,NuclearYAPisanindependentprognosticmarkerforHCCrecurrence,CoxRegression,Summary,YAPconferstumorigenicandmetastaticpotentialsinhepatocytes,asevidencedbyenhancedaptitudesincellviability,anchorage-independentgrowth,migrationandinvasion.YAPnuclearaccumulationwasfoundinthe53.7%ofHCC,correlatedwithpoorertumordifferentiationandhigherserumalpha-fetoprotein(AFP)levels.NuclearYAPisanindependentpredictorforHCC-specificrecurrence-freesurvival.YAPplaysanimportantroleinHCCdevelopmentandprogression.,Acknowledgement,新加坡国立大学外科系和药学系Asso.Prof.JohnM.Luk香港大学外科系