四川大学教案.doc

四 川 大 学 教 案【理、工科】周次第 18 周，第 1 次课备注章节名称第十二章 群体遗传与进化授课方式理论课()；实验课( )；实习( )教学时数3教学目的及要求掌握如何计算群体的基因频率和基因型频率掌握Hardy-Weinberg 定律的内容了解影响Hardy-Weinberg平衡的因素了解分子进化的研究方法和内容教 学 内 容 提 要时间分配The goal of population genetics Key concepts第一节 Hardy-Weinberg 定律1. Genotype frequency and allele frequencyDefinition, How to calculate 2. Hardy-Weinberg Law3. Testing for Equilibrium4. The Hardy-Weinberg law provides a method for calculating the frequency of heterozygotes in a population 第二节 改变群体基因频率的因素1. Natural selection is a potent force of evolution2. Mutation is the source of new alleles, but a weak force of change in allele frequencies3. Migration homogenizes allele frequencies across populations4. Genetic drift is random change in allele frequencies and is especially important in small population 5. Nonrandom mating changes genotypes frequencies, but not allele frequencies6. How human activity affects the evolution of human pathogens and crop pests1015510555510515 第 页第三节 分子进化1. The origin of life on earthThe evolution of living 2. Organisms: inference from the fossil record3. The evolution of the genome4. Molecular Phylogenetic Tree 1551510教学重点与难点Hardy-Weinberg 定律的基本内容，哪些因素会影响群体达到平衡？如何直接计算群体的基因频率和基因型频率，如何利用Hardy-Weinberg平衡计算基因频率和基因型频率遗传漂变在改变群体遗传结构中的作用。分析系统进化树的意义讨论、练习、作业如何判断一个群体是否处于平衡状态？基因频率的改变对群体进化有何意义？解释人体中耐药性细菌是如何产生的？从中我们可得到什么启示？基因组是如何进化的？教学手段计算机多媒体投影系统教学光盘参考资料Genetics (From genes to genomes) , Leland Hartwell, 4th Edition, 2010, Mcgraw-Hill Companies, IncConcept of Genetics, William S.Klug, 10th Edition, 2011, Prentice Hall , IncIntroduction to Genetics Analysis, Anthony J.F. Griffiths, 10th Edition, 2011, W.H.Freeman, IncPrinciple of Genetics, D.Peter Snustad, 6th Edition, 2011, John Wiley & Sons, IncGenetics: A Conceptual Approach, Benjamin A.