大鼠实验性脑梗X后早期CT表现的法医学研究

大鼠实验性脑梗X后早期CT表现的法医学研究 【摘要】目的探讨24 h内脑梗死ct值的变化与梗死时间的关系以及ct表现。方法采用线栓法制作大鼠大脑中动脉梗 死模型，于梗死后2、3、4、6、8、12、24 h进行头颅ct冠状位扫描。观察ct图像，测量两侧大脑半球对称部位的ct值，并求出 两者的差值。结果线栓法大鼠脑梗死后最早于3h肉眼即可辨别梗死灶，其患侧ct值与健侧有显著性差异，且脑梗死健、患 侧ct值的差值与时间呈直线正相关。结论血管栓塞引起的脑梗死最早于梗死发生后3 h即可诊断，并可通过脑梗死两侧ct 值的差值的计算来推断脑梗死发生的时间。 【关键词】脑梗死；断层摄影术；动物 【】d9191 【】a 【】10079297(20xx)04030104 early ct signs forensic medical study in experimental cerebml infarction in ratswa ng a i-reng,zha ng linglide partment of forensic medical，tonti medical college，huazhong unweniof science and technologywuhan 430030,prchin 【abstract】objective to investigate the relationship between ct value and time and，the ct signs in early cerebral infare tionmethods the intraluminal thread olusion model in the middle cerebral anew of rats was establishedserial scans in coronal planes were performed at 2，3，4，6，8，12 and 24 hours after olusionthe ct signs of cerebral infarction，mean while measured ct values of both infracted and healthy brain tissues were analyzed，then the differences calculated results the hypodense lesion could be observed by naked eyes at least 3 hours after cerebral infractionthe ct value differences of both sides bear a statistically significant linear relationship with timeconclusion cerebral infarction due to blood vessel embolism could be diagnosed at least 3 hours after middle cerebral artery olusionit suggests that the olusion time could be evaluated by the differenees of ct values 【key words】cerebral infarction；tomography；animals 在法医临床检案工作中脑梗死的案例时常遇到， 对于这类案件，鉴定重点是鉴别脑梗死是由疾病引起 还是外伤导致。在多个鉴别因素中，脑梗死发生时间 是鉴别伤与病的关键。ct作为一种普遍、快捷的检查 方法， 目前在临床上已经成为脑梗死首选的检查手 段，也是法医临床鉴定中诊断脑梗死的重要依据。但 对于脑梗死在ct平扫中最初何时可以明确诊断，至 今仍无统一看法。一般认为，脑梗死发病l224 h内ct 平扫多不能显示。1l但有实验表明，梗死灶最初于 6 h内即可显示： 陈彦芳等31的研究结果表明，脑梗 死后3 h，ct即可看到病变；甚至有脑梗死后2 h即有 阳性表现的报道。 本文就实验性大鼠脑梗死早期