硕士研究生英文文献汇报实例PPT演示课件

AgesandStagesQuestionnaireat3YearsforPredictingIQat56Years幼儿3岁时的发育情况（年龄和发育阶段问卷结果）能预测其5-6岁时的IQ,PEDIATRICSVolume139,number4,April2017IF:6.476Yaoxing,2017-11-07,1,Contens,BackgroundObjectivesMethodsResultsDiscussionStrengthsandlimitationsConclusionsImplications,2,2020/6/12,Abbreviations,ASQ:Ageswhetherthechildwasafirstbornchild;behavioralproblemsatage3,ratedviatheStrengthsandDifficultiesQuestionnaire(SDQ),andwhetherthechildhadstartedpreschoolatage3.2.Maternalcharacteristics:maternaleducationallevel,occupation,anddepressivesymptomsassessedwiththeCenterforEpidemiologicStudiesDepressionscale.3.Familycharacteristics:parentsoccupationandfinancialdifficultiesreportedbytheparentswhenthechildwas3.,15,2020/6/12,3.Statisticalanalysis,1.ChildrenincludedinthecurrentanalysiswerefirstcomparedwiththeotherchildrenintheEDENcohortwhowerenotincluded.2.Resultsforthe36-monthASQscoreandthe5-to6-yearWPPSI-IIIevaluationweredescribedasmeansSDsandmedianwithinterquartileranges(IQRs).3.Thereceiveroperatingcharacteristic(ROC)curvelinkinglowIQ(85)andASQscorewasusedtodeterminetheoptimalcutoffvaluefortheASQscore.4.A3-stepanalysiswasthenconductedwithlogisticregression.5.StatisticalanalyseswereperformedinSASsoftwareversion9.3.,16,2020/6/12,Results,17,2020/6/12,ASQscoresweredeterminedatameanageof37.30.8months.Themean36-monthASQscorewas27030,withamedianof280(IQR260290).IQwasmeasuredatameanageof67.21.8months.TheMeanIQwas10313,and69children(7.3%)hadanIQ85.Allchild,maternal,andfamilyfactorsstudied,exceptgenderandmaternaldepressivesymptoms,weresignificantlyassociatedwithASQscore.,18,2020/6/12,1.CharacteristicsoftheStudypopulation(andcomparedwithchildrenintheEDENCohortbutnotincludedinthestudy),19,2020/6/12,ChildrennotincludedweremoreoftenfromNancyCenter,werelessoftenfirstborn,hadmotherswithlowereducationallevels,andhadparentswithloweroccupationallevelsthanchildrenincluded.,20,2020/6/12,21,2020/6/12,2.,IQatage5to6yearsaccordingto36-monthASQscore(ROCcurve),22,2020/6/12,Theareaunderthecurvewas0.78(95%confidenceintervalCI,0.720.84).即IQ85的幼儿ASQ值小于正常组的概率为0.78。,TheoptimalcutoffvalueforpredictinglowIQwas270(sensitivitywas0.77,specificitywas0.68).Positivepredictivevaluewas0.16,thenegativepredictivevaluewas0.97（提示3岁时ASQ得分270的幼儿5-6岁时IQ85的可能性小）,ROC曲线下面积与工具诊断准确度高低高0.90-1.00=excellent(A)中0.80-0.90=good(B)0.70-0.80=fair(C)低0.60-0.70=poor(D)0.50-0.60=fail(F),23,2020/6/12,3.FactorsassociatedwithIQ85onceASQistakenintoaccount,24,2020/6/12,单变量,多变量,25,2020/6/12,26,2020/6/12,TherisksoflowIQwassignificantlyhigherinchildrenwithanASQscore270andamaternaleducationallevelathighschoolorbelow.,27,2020/6/12,Discussion,28,2020/6/12,1.TheprevalenceoflowIQwasprobablyunderestimatedinthestudy.,Aprevalenceof16%couldhavebeenexpected,consideringthedistributionofIQ(mean=100,SD=15).Theprevalenceinthisstudywas7.3%,whichwasalsointhelowerrangeoftheprevalenceobservedinthegeneralpediatricpopulationexhibitingsometypeofdevelopmentaldelayordisabilitybeforeenteringschool(5%15%).,29,2020/6/12,2.ThetotalASQscoreusedinthestudy.,Asreportedinseveralpreviousstudies,totalASQscoresprovideaglobalevaluationofachildsfunctioning,whichseemsrelevantforpredictinglaterglobalcognitivefunctioning.Usingthetotalscoreinsteadofthecutoffpointsbydomain（能区）couldmisslesssevereproblemsrestrictedto1domain.OtherresearchersfoundthatinthegeneralpopulationtheuseofASQtotalscorecouldberecommendedbecauseofthelowprevalenceofdifficulties.,30,2020/6/12,UsingtheASQatage3couldleadtodecisionstoperformmoredetaileddevelopmentalassessmentsforchildrenwithlowerscores.Thegoalwouldbetosetupearlyinterventionsdesignedtohelpthechildachievehisorherfulldevelopmentalpotential.,31,2020/6/12,3.FactorsassociatedwithIQatage5to6yearsonceASQscorewastakenintoaccount.,Theobjectiveofthisstudywastoidentifythefactorsstillhavinganimpactbetweenage3and5to6years,onceabilitiesatage3weretakenintoaccount.Interventionsconductedbetweenage3and5to6years,suchasspeechtherapy,werenotstudied.LowermaternaleducationallevelwasassociatedwithlowerASQscore.Thisassociationunderlinesthefactthatsocioeconomicbackgroundplaysacrucialroleinchilddevelopmentthroughoutearlychildhood.,32,2020/6/12,ChildrenwhosemothershadnooccupationalactivityhadagreaterriskoflowIQonceASQscorewastakenintoaccountandafteradjustmentfortheirmotherseducationallevel.Itispossiblethatmaternaloccupationalactivityservesasaproxy(代表)forvariousaspectsofsocioculturalandeconomicbackground.,33,2020/6/12,Strengths,1.Largesamplesize(madeitpossibletostudynumerousfactors).2.TheASQscorewasstudiedinrelationtothegoldstandardevaluationofcognitiveabilityatage5to6years(WPPSI-III).3.ThepsychologistsperformingtheWPPSI-IIIwereblindedtotheASQscore.,34,2020/6/12,Limitations,1.TheIQat5to6yearsitselfalsohaslimitsandisnotaperfectpredictoroflonger-termoutcomes.2.Only69childrenhadanIQ85,leadingtoalackofpowerforstudyingassociatedfactors.3.959childrenwerelosttofollow-upbetweenbirthandage5to6years.4.Childrennotincludedhadalowersocioeconomicbackgroundthanchildrenincluded.5.MothersinthecohorthadahighereducationallevelthanthoseintheoverallFrenchpopulation.,35,2020/6/12,Conclusions,36,2020/6/12,1.Resultssuggestthatthe36-monthASQscorecouldbeusefulinpredictingtheriskofhavinganIQ85atage5to6years.2.TheASQscoressensitivityis0.770.11,with0.680.03specificityforacutoffvalueof270.3.AtagivenASQlevel,socioeconomicbackgroundaffectschildrensdevelopmentbetweenage3yearsandage5to6yearsandshouldbetakenintoaccountwheninterpretingtheASQscoreasapredictivetool.,37,2020/6/12,Implications,学习1.选调查工具之前要对其进行详尽的了解，包括界值的确定，没有常模的情况下可以借助用ROC曲线；2.任何调查都存在抽样误差，在已有数据中选取