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氧化氮合酶在骨关节炎中的作用A1A0A0A3A3A4A2A5A6A7A8A9A10A11A12A13A14A15A16A17A18A19A20A21A22A23A24A25A26A27A28A29A10A11A12A13A14A30A31A32A27A33A34A35A16A17A18A19A25A36A37A38A39A40A41A42A43A44A28A45A46A47A48A49A50A51A52A53A54A55A56A57A25A58A59A60A61A62A63A38A64A65A66A67A68A69A67A70A71A40A72A73A74A72A75A72A76A10A11A12A13A14A77A11A78A79A25A10A11A12A80A81A49A44A82A25A83A84A65A85A86A87A88A65A85A40A10A11A12A13A14A30A31A32A30A31A81A49A10A11A12A78A79A63A54A89A15A16A17A18A19A34A35A24A20A90A26A27A40A91A92A93A3A10A11A12A13A14A94A10A11A12A94A16A17A18A19A95A96A97A98OSTEOARTHRITISA99OAA100A101A102A103A96A97A104A95A105A106A107A108A109A110A95A111A112A113A114A115A116A117A118A106A96A97A119A120A121A122A123A124A125A126A100A127A128A129A117A101A102A96A97A119A105A99A130A131A119A132A133A134A135A112A136A137A112A138A120A139A140A141A142A143A103A96A97A144A145A107A95A111A112A113A110A146A147A148A149A127A114A128A129A120OAA117A131A119A150A151A152A110A102A153A154A155A99A156A157A114A158A131A106A159A160A131A106A120A160A131A106OAA161A162A163A117A164A119A158A165,A166A167A168A107A98A106A96A97A119A107A169A170A106A171A131A172A106A95A96A97A119A107A173A174A106A171A126A157A175A106A176A119A177A178A158A131A106OAA119A165A110A131A119A179A180A181A182A183A157A162A163A99A156A184A185A134A135A112A136A107A186A187A188A189A107A190A168A107A191A192A107A193A194A177A195A102A165A196A197A198A199A961A120A101A200A201A114OAA100A121A202A203A159A113A204A203A165A196A205A206A207A189A208A104A95A209A210A107A209A210A211A212A111A110A104A95A208A95A213A214A215A216A159A217A218A219A220A117A221A222A120A223A224A225A226A227A228A229A230A231A232A217A233A234INDUCIBLENITRICOXIDESYNTHASEA99INOSA235A121OAA236A237A238A117A207A189A110A230A231A232A217A233A239A180A240A207A241A242A1201A243A244A245A246A247A244A245A246A247A248A249A250A251,A252A253A254NITRICOXIDE,NOA255OAA23A0A1A0A2A3A4A5A6A72A8A27OAA154A9A10A155A11A12A13A14A15NOA157A16A17A18A19A20A21,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,A88A94A10A9A11A12A98A99A26A100A361995A102BLANCOA388A149A21A13A51A103A104A105A38NOA251A106A17A18A20A107A81A108NOA33A109A110A111A112A20A10A9A11A12A98A99A26A197A113A115A116OAA76A84A10A9A11A12A98A99A117NOA118A119A120A80A41A177A75NOA109A110A10A9A11A12A98A99A20A122A106A156A65A123A85A124A126A26A127A145A65A10A9A11A12A46A48A128A49A20A130A131,A88A94A46A48A128A49A132A133A46A48A20A134A135A26STUDERA389A136INOSA137A138A140A141A10A9A11A12A41A22A23A10A9A11A12A17A18A20A19A160NOA90A145A65A10A9A137A143A46A48A128A49A20A130A131A41A88A142A46A48A128A49A146A132A133A46A48A20A121A135A147A67A149A211011A148A120A150A151A71A20NOA33A87A20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