滤泡性淋巴瘤

1、Follicular Lymphoma Contents incidence and epidemiology diagnosis and molecular biology staging and risk assessment treatment follow-up and long-term implications FL Sites and enrollment by region. Follicular lymphoma is the second most common subtype of lymphoma (although its incidence may be lower

2、 in some parts of the world such as Asia) and represents about 20% to 25% of cases of non-Hodgkin lymphomas in the U.S. and Europe. Incidence and Epidemiology Diagnosis and Molecular biology Histological and pathological Immunohistologic findings GENETIC ABNORMALITIES Grading of follicular lymphoma

3、Annals of Oncology Advance Access CD19+ 、CD20+ 、CD79a+、CD10+、Bcl6+ BCL2 rearrangement、t( 14；18)、t( 8；14) Histological and pathological Grading of follicular lymphoma Architectural Patterns in Follicular Spectrum of Follicle Morphology Immunoarchitectural Patterns of Follicualr lymphoma 1.Describe co

4、ntents for a Chart - Description of the companys sub contents - Description of the companys sub contents 2.Describe contents for a Chart - Description of the companys sub contents - Description of the companys sub contents Immunohistologic findings IHC GENETIC ABNORMALITIES GENETIC ABNORMALITIES The

5、meGallery is a Design Digital Content a radiation consolidation may be considered depending on tumour location and expected side-effects. In the small proportion of patients with limited non- bulky stages I-II, radiotherapy is the preferred treatment having acurative potential, whereas the 22 Gy sch

6、edule is inferior and is merely palliative. In selected cases, watchful waiting or rituximab monotherapy maybe considered to avoid the side-effects of radiation. Stages IIIIV Treatment Indication TREATbulky disease B symptoms ascites, pleural effusion vital organ compression haematopoietic impairmen

7、t rapid lymphoma progression Criteria for delaying treatment in FL Watchful waiting Stages IIIIV Immuno- chemotherapy R-CHOP R-CVP R-FC R-FM R-B Immunotherapy Rituximab Radio- immunotherapy 131I-tositumomab First line Watchful waiting Click to add Text Click to add Text Click to add Text Click to ad

8、d Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Description of the contents Description of the contents Description of the contents Treatment consolidation/maintenance Rituximab m

9、aintenance for 2 years Radio- immunotherapy consolidation . . ASCT 利妥昔单抗维持治疗可作为高危和高肿瘤负荷患者选择 50% 70% 160% 230% 100% 150% 380% 300% Year Clinical trials examining rituximab maintenance therapy Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text C

10、lick to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Key outcomes of the PRIMA trial Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Treatment-Summary Step 1 Step 2 Ste

11、p 3 A repeated biopsy is strongly recommended. Observation is an accepted approach in asymptomatic patients with low tumour burden. Salvage treatment Relapsed Disease Step 3 Step 4 Better OS 50% 70% 160% Year EORTC 20981 70% 160% 230% 100% 150% 300% Year EORTC 20981 Year German Low Grade Lymphoma St

12、udy Group (GLSG) Year ASCT for Relapsed FL Year ASCT for Relapsed FL Year RESORT (Rituximab Extended Schedule or Re-Treatment Trial) In lowtumor burden FL, a re-treatment strategy uses less rituximab while providing disease control comparable to that achieved with a maintenance strategy. Click to ad

13、d Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text GENETIC ABNORMALITIES Graphic summary of common genetic lesions in follicular lymphoma Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to

14、 add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Description of the contents Description of the contents Description of the contents New Therapy Follow-up and Long-term implications Response Evaluation ent Title 淋

15、巴瘤疗效评定（包括PET） Immunoarchitectural Patterns of Follicualr lymphoma GENETIC ABNORMALITIES ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc. Guild Design is one of aligned company with Microsoft Ltd, and we develop and provide the design templates for Office 97, 2000, and XP. GENETIC ABNORMALITIES A mo