wi原理及临床应用课件

1、The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用1 SWISWI的原理及临床应用的原理及临床应用 2016-12-02 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用2 SWI成像原理简介 SWI的临床应用 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临

2、床应用3 SWI成像原理 SWI是一种利用不同组织间的磁敏感性差 异而成像的技术，对小静脉、微出血和 铁沉积更敏感。 成像基础：组织间磁敏感度差异 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用4 SWI成像原理 以T2*加权梯度回波序列作为序列基础， 分别采集强度数据和相位数据的方式，并 在此基础上进行数据的后处理，可将处理 后的相位信息叠加到强度信息上，更加强 调组织间的磁敏感性差异，形成最终的 SWI图像 The First Affiliated Hospital Zhe

3、jiang Chinese Medical University wi原理及临床应用原理及临床应用5 与SWI相关的组织磁敏感性特点 血红蛋白及其降解产物 氧合血红蛋白：Fe2+与氧结合，没有不成对的 电子，为反磁性 去氧血红蛋白：带有4个不成对的电子，顺磁性 正铁血红蛋白：血红蛋白进一步氧化为，含5个 不成对电子，具有较强顺磁性，但磁敏感性较 弱，主要缩短T1弛豫时间 含铁血黄素：高度顺磁性，磁敏感性较强 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用6 非血红蛋白铁及钙化的

4、磁敏感性 非血红蛋白铁在体内以铁蛋白常见，为高度顺 磁性。正常人随年龄增加，铁在脑内沉积增加 ，但在某些神经变性疾病中，如帕金森病、阿 尔茨海默病等，铁异常沉积 钙化：在脑内的结合状态是弱反磁性，但大多 数情况下可以产生局部磁场，导致信号去相位 ，造成T2*缩短，信号减低 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用7 SWI的影像对比：用于小静脉显像 The First Affiliated Hospital Zhejiang Chinese Medical Univers

5、ity wi原理及临床应用原理及临床应用8 无论顺磁性物质还是反磁性物质，只要能 改变局部磁场，导致空间相位的改变，就 能产生信号的去相位，造成T2*时间缩短。 去相位的结果不取决于物质是顺磁性还是 反磁性，而取决于物质在一个体素内能多 大程度地改变磁场 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用9 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用10 SWI

6、的临床应用 血管源性病变 肿瘤性病变 颅脑外伤 神经退行性疾病 其他 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用11 血管源性病变 血管源性病变 海绵状血管瘤 动静脉畸形 毛细血管扩张症 淀粉样脑血管病（CAA） 脑梗死及出血 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用12 左侧小脑海绵状血管瘤合并出血左侧小脑海绵状血管瘤合并出血 The First A

7、ffiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用13 多发出血的海绵状血管瘤多发出血的海绵状血管瘤 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用14 血管畸形血管畸形 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用15 右额叶深部血管发育畸形右额叶深部血管发育畸形 T

8、he First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用16 右枕叶静脉畸形右枕叶静脉畸形 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用17 左侧顶枕叶动静脉畸形左侧顶枕叶动静脉畸形 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用18 左侧大脑半球静脉发育

9、畸形左侧大脑半球静脉发育畸形 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用19 放射性毛细血管扩张症放射性毛细血管扩张症 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用20 淀粉样脑血管病淀粉样脑血管病 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临

10、床应用21 淀粉样脑血管病淀粉样脑血管病CAA The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用22 MIP SWI CT 左侧基底节区梗死左侧基底节区梗死 合并微小出血灶合并微小出血灶 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用23 肿瘤性病变 肿瘤性病变 SWI可以显示肿瘤的边界、静脉、出血及钙 化等 The First Affiliated Hospit

11、al Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用24 T1-CEFlairSWI The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用25 SWIT1-CE 胶质瘤合并出血胶质瘤合并出血 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用26 右侧脑室肿瘤静脉分布和出血灶右侧脑室肿瘤静脉分布和出血灶 The F

12、irst Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用27 颅脑外伤性疾病 颅脑外伤性疾病 弥漫性轴索损伤（DAI） 外伤性脑出血及梗死 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用28 颅脑外伤性疾病 弥漫性轴索损伤DAI The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理

13、及临床应用29 弥漫性轴索损伤DAI The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用30 弥漫性轴索损伤弥漫性轴索损伤DAI The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用31 外伤后右侧额叶微小出血灶外伤后右侧额叶微小出血灶 The First Affiliated Hospital Zhejiang Chinese Medical University wi

14、原理及临床应用原理及临床应用32 神经退行性疾病 神经退行性疾病 以脑内铁质沉积增多为特征 Alzheimers disease Parkinsons disease 钙质沉积 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用33 Alzheimers disease 齿状核铁质含量增高齿状核铁质含量增高 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用34 Par

15、kinsons disease 黒质区燕尾征消失黒质区燕尾征消失 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用35 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用36 钙化性疾病 双侧苍白球钙化双侧苍白球钙化 The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及临床应用原理及临床应用37 钙化性疾病 少突胶质细胞瘤钙化斑少突胶质细胞瘤钙化斑 The First Affiliated Hospital Zhejiang Chine