通过呼吸道感染的微生物

1、 Main pathogenic microbes (Bacteria) Main pathogenic microbes (virus) Other main pathogenic microbes wresistance drying acids and alkalies dyes (malachite green) wsensitive moist heat 70% ethyl alcohol ultraviolet light Mycobacterium tuberculosisMycobacterium tuberculosisMycobacterium tuberculosis 2

2、) Pathogenicity wcapsule wlipids cord factor(索状因子索状因子) , damage mitochondria membrane phosphatides(磷脂磷脂), tubercules sulfatides(硫酸脑苷脂硫酸脑苷脂), inhibit phagosome- lysosome fusion waxes(蜡质蜡质D) adjuvant proteins tuberculin wInfectious reservoirs patients,carriers wtransmitted ways: respiratory tract 、ali

3、mentary tract、skin wpulmonary primary infection secondary infection wextra-lung infection 4) Immunity4) Immunity wprevention w treatment ) 6) prevention & treatment wGram-positive wlancet-shaped wIn pairs wcapsulate wautolysis 2) Pathogenicity 2) Pathogenicity 菌菌鼻咽部繁殖鼻咽部繁殖 局部炎症：局部炎症： 假膜假膜早期致死早期致死 外毒

4、素外毒素 心肌炎心肌炎 软腭麻痹软腭麻痹 声嘶声嘶 肾上腺功能障碍肾上腺功能障碍 晚期致死晚期致死 入血入血 This child has diphtheria resulting in a thick gray coating over back of throat. This coating can eventually expand down through airway and, if not treated, the child could die from suffocation CDC Structure core w(-)ss RNA, separated segments s

5、even（type C)or eight (type A, B) whelical nucleoprotein (NP) envelope: 2 layers wM1 protein: coded by virus wlipid bilayer membrame: from host hemagglutinin (HA) neuraminidase (NA) wantigenic drift Limited spread wantigenic shift Worldwide spread w 3) prevention & treatment The other microbes wresistance drying acids and alkalies dyes (malachite green) wsensitive moist heat 70% ethyl alcohol ultraviolet light 2) Pathogenicity wcapsule wlipids cord factor(索状因子索状因子) , damage mitochondria membrane phosphatides(磷脂磷脂), tubercules sulfatides(硫酸脑苷脂硫酸脑苷脂), in