医学免疫学试题及答案供临床、法医、影像和预防等专业用（Medical immunology questions and answers for clinical forensic imaging and prevention and other professional use）

1、医学免疫学试题及答案供临床、法医、影像和预防等专业用（Medical immunology questions and answers for clinical, forensic, imaging and prevention and other professional use）Medical immunology testFor clinical, forensic, imaging and Preventive MedicineFirst, choose a question (choose a best answer, fill in brackets, 1 points for e

2、ach question, 30 points)(1.) the correct concept of immunity is that.A. organisms defense against pathogenic microorganisms B. the bodys resistance to infectionC. airframe recognizes and eliminates the function of antigenic foreign bodies. The D. organism eliminates the ability to kill mutant cellsT

3、he E. organism functions as a tissue cell that clears itself and dies(2.A) the cause of rheumatic heart disease caused by hemolytic streptococcal infectionA. release of cryptic antigens, aberrant regulation of B.Th cells, and modification of C. autoantigenThe role of D. determinant in the expansion

4、of E. antigen() 3.IgE antibodies are the major causeA., rapid hypersensitivity, B., delayed hypersensitivity, C. cytotoxic hypersensitivityD. vasculitis type hypersensitivity E. autoimmune disease(4.) cytokines that support the growth of T cells in vitro areA.IL-1, B.IL-2, C.IL-3, D.IL-4, E.IL-5(5.)

5、 the study of medical immunology isThe interaction between A. pathogen infection and defense capability, B. antigen and antibodyC. the principle and application of human immune phenomena D. animals respond to an immune response produced by a primary stimulusE. cell mutation and immune surveillance f

6、unction(6.) the main antibody type of the BCR is?A.IgG and IgM, B.IgA and IgD, C.IgD and IgE, D.IgM and IgD, E.IgE, and IgD(7.) immune surveillance function refers to the organismA. is resistant to infection by pathogenic microorganisms - B. kills and clears the cells of its own mutant cellsC. ident

7、ifies and eliminates the function of foreign bodies. D. clears out the functions of aging and dying cellsE. prevention of parasitic infections(8.) the ligand for the adhesion molecule ICAM-1 isA.VCAM-1, B.LFA-1, C.LFA-2, D.LFA-3, E.VLA-4(9.) neutralizing antibodies to the virus, mainlyA.IgG, B.IgA,

8、C.IgM, D.IgD, E.IgE(10.) the antigen that causes allograft rejection isA. allogeneic antigen, B., heterologous antigen, C. autoantigen, D., E. antigen, concealed antigen(11.) the antibody with the C1q recognition site isA.IgM IgGFourB.IgGFrom 1 to 3IgA C.IgM D.IgM IgGFrom 1 to 3E.IgGFrom 1 to 3IgE(1

9、2.) complete antigen havingA., foreign and specific B., immunogenicity and antigenicity, C., antigenicity, and foreign bodyD. physics, chemistry, complexity and specificity, E., foreign body sex and immunity () 13. can mediate ADCC cell should includeA., CTL and NK cellsB. macrophages, neutrophils,

10、and NK cellsC. neutrophils and B cellsD., Th cells, CTL and NK cellsE., CTL, eosinophils, and mast cells() 14. about the description errors of class I moleculesA. inhibits the killing activity of NK cells, and B. alpha chains and beta 2m are encoded by MHC-B, C and A lociC. is mainly expressed as en

11、dogenous antigen, D. binds to CD8 molecules and E. distributes in all nucleated cells(15.) the mechanism that does not belong to autoimmune tolerance is thatThe negative selection of A.B cells in maturation of bone marrow; B. clones; non allergic C. clones; ignoredNegative selection of D.T cells in

12、thymic maturation and E. immunosuppression(16.IL-2) the major producing cell isA.Th1 cells, B.Th2 cells, C.CD8 T cells, D.NKT cells, E., gamma delta cells(17.) the following belongs to the B7 moleculeA.CD40, B.CD80, C.CD152, D.CD28, E.CD40L(18.) the immune response between cells and cells is not lim

13、ited by MHCA.Th1 cell and APC B.Th2 cell and B cell C.CTL recognize target cell antigenD.NK cells kill target cells, E.CTL cells kill target cells(19.) repeated episodes of diseases that cause a relatively reduced complement level areA. systemic lupus erythematosus, B., hyperthyroidism, C. diabetes,

14、 D. leukemia, E., anaphylactic shock(20.) the following ones that do not belong to the IgG property areA. content is the largest, B. affinity is high, C. half-life is long, D.ABO blood group antibody E., anti Rh blood type antibody(21.) infection by intracellular parasites belongs toA. delayed hyper

15、sensitivity, B., rapid hypersensitivity, C. cytotoxic hypersensitivityD. vasculitis type hypersensitivity E. autoimmune disease() 22. complement C3 converting enzyme isA.C4b2a, B.C3bBb, C.C2bBb, D.C4b5b, E., C3b4b(23.) the following diseases belong to the immune complex type hypersensitivityA. tuber

16、culosis, B., serum sickness, C., pollen induced asthmaD. hyperthyroidism, E., anaphylactic shock(24.) antibodies that protect newborns against infection are mainlyA.IgG, B.IgA, C.IgD, D.IgM, E.IgE() 25.The factors that do not belong to the induction of immune tolerance areA. small molecule soluble a

17、ntigen, B. granule antigen, C., high dose antigenThe D. antigen enters the E. minimal dose antigen through the digestive tract(26.) contact dermatitis asType A. hypersensitivity, type B. hypersensitivity, type C. hypersensitivityD. type IV hypersensitivity, E. autoimmune disease (27.) is a cytokine

18、that causes fever in the bodyA.IL-2, B.IFN, gamma, C.IL-1, D.TNF, alpha, E.TGF() 28.CD4 and MHC class II molecular binding sites areA. alpha 1, B. alpha 2, C. beta 1, D. beta 2, E. alpha 3(29.) the cytokines that do not participate in delayed hypersensitivity areA.IL-2, B.IL-4, C.GM-CSF, D.IFN-, gam

19、ma, E.TNF- beta(30.) a biologically active substance independent of the immediate hypersensitivity reactionA. leukotrienes, B., platelet activating factor C., interferon D., prostaglandin D2, E. histamineTwo. Fill in the blanks (0.5 cents per room, 10 points)1. complement can be activated by 1, 2 an

20、d 3 pathways.The mechanisms by which 2.CTL kills target cells should include 4, 5, and 6.3.FcR can be divided into 7, 8, 9, 10 and 11.4., the immune cells are 12, 13, 14, 15, 16, 17, 18, 19 and 20, etc.Three. Explain the noun (2.5 points, 20 points each)1. epitope 2.mIg 3., antigenicity 4.ADCC, 5.MH

21、C 6, antibody 7., complement 8., hypersensitivityFour. Janes answer (4 points per game, 8 points)1. describe the characteristics of primary immune response.2. briefly describe the main functions of the Fc segment.Five, discussion questions (6 points per subject, 12 points)1. to describe the pathogen

22、esis of cytotoxic hypersensitivity.2. to test the major differentiation antigen and its action of alpha beta T cells.Six. Analysis questions (20 points)1. NK cells were isolated from a normal peripheral blood. Then, with isotope labeled target cells (a tumor cell)The cell lysis of the target cells w

23、as recorded to detect the killing function of NK cells. The test results are as follows:Experimental results of killing target cells by NK cellsTreatment scheme cell lysis (%)No NK cells, 4Add NK cells 12NK cell + anti target cell antibody 67The purified perforin 95 was addedAsk: (1) why can NK cell

24、 show partial killing function to target cell? Whats the cause of the increased cytotoxicity of NK cells by adding target cell antibodies (5 points)?(2) please explain the result after adding purified perforin (3 points).2. please analyze the test results on the table and point out which of the 2 T

25、cell clones is CD4Which one is T cells.CD8T cells, and why (12 points)?Test results of influenza virus stimulated clonal proliferation of T cellsT cell proliferation response antigen to APC treatmentClone 1, clone 2No,Live influenza virusThe inactivated influenza virusEmetine - + live influenza viru

26、sLive influenza virus + - chloroquineNote: - indicates that the untreated or proliferative reaction is negative; + indicates positive proliferative response.Cloning 1 and clone 2 are 2 T cell clones obtained from mice infected with influenza viruses, one of which isThe MHCI class is restrictive, and

27、 the other is the MHCII class restriction.APC was derived from macrophages of mice with the above T cell clones.The table in the 2 row refers to macrophages in the flu virus before, first with emetine (emetine) or chloroquine treatment.Emetine is a protein synthesis inhibitor, chloroquine inhibited

28、fusion of phagosomes and lysosomes.Medical Immunology examination questions A reference answersFor the 89 phase of clinical, forensic, imaging and preventive medicine for May 2005First, choose a question (choose one of the best answers, 1 points per subject, 30 points altogether)1.C, 2.E, 3.A, 4.B,

29、5.C, 7.B, 8.B, 9.A, 6.D, 10.A, 11.D, 12.B, 13.B, 14.B, 15.E, 16.A17.B, 18.D, 19.A, 20.D, 21.A, 22.B, 23.B, 24.A, 25.B, 26.D, 27.C, 28.D, 29.B, 30.CTwo. Fill in the blanks (0.5 cents per room, 10 points)1. complement can be stimulated by 1 classical (C1 or conventional), 2 alternative (C3 or bypass)

30、and 3 MBL pathwaysLive.The mechanism of 2.CTL killing target cell should include 4 FasL inducing target cell apoptosis and 5 cytotoxic granule forming perforationTarget cell apoptosis was induced by soluble target cells and 6 granzyme.3.FCR can be divided into 7 Fc gamma R I, 8 Fc gamma R II, 9 Fc g

31、amma R III, 10 Fc alpha R, and 11 Fc epsilon R I, etc.FourThe main immune cells were 12 T cells, 13 B cells, 14 NK cells, 15 macrophages and 16 dendritic cells,17 neutrophils, 18 basophils, 19 eosinophils and 20 mast cells.Three, noun explanation (2.5 points per game, 20 points)1. epitope: antigen p

32、resence (surface B and CD8T cell epitope or internal CD4T cell epitope) for T and B cellsPartial structure of identification.2.mIg: antigen receptor BCR, also called membrane antibody, on the B cell membrane.3. antigenicity: the nature of the specific combination of immune products (antibodies and e

33、ffector T cells) associated with the antigen.4.ADCC: antibody dependent cell-mediated cytotoxicity. IgG or IgA bind to target cells after their Fc segments and carry FcThe effect of cell receptor gamma (NK cells, M PMN and phi) effector cells or Fc alpha receptor (PMN) binding, release perforinOr gr

34、anzyme causes target cell lysis or apoptosis.5.MHC: to encode major histocompatibility antigens, MHC class I molecules and MHC class II molecules gene complexes.6. antibodies: antigens stimulate B cells to differentiate into plasma cells, which are produced by plasma cells that bind specifically to

35、their respective antigensAlbumen.7. complement: a group of heat labile proteins that have esterase activity after activation in vertebrate serum and body fluids.8. hypersensitivity: physiological and pathological damage caused by immune response.Four. Janes answer (4 points per game, 8 points)1. des

36、cribe the characteristics of primary immune response.(1) the incubation period was long; (2) the antibodies produced were mainly IgM; (3) the antibody affinity was low; (4) the immunity lasted for a short time.(1 points per item).2. briefly describe the main functions of the FC segment.(1) activatio

37、n of complement (IgM and IgG segments) (2) through the placenta (IgG segment Fc) (3) via the Fc gamma receptor (Fc)And Fc alpha receptors mediate ADCC action; (4) promote phagocytosis by conditioning the Fc gamma receptor and the Fc receptor.Five, discussion questions (6 points per subject, 12 point

38、s)1. Describe the pathogenesis of cytotoxic hypersensitivity (1.5 points per item).(1) antibody IgM and IgG mediate complement activation to lyse target cells;(2) the immune enhancing effect mainly by complement fragments and antibodies through the corresponding receptors M and PMN by phi;(3) by ADC

39、C with antibody mediated target cells by NK cells, M and PMN;(4) the stimulating antibody IgG4 (long-acting thyroxine) acts on the thyroid stimulating hormone receptor causing hyperthyroidism.2. test the major differentiation antigen and action of alpha beta T cells (1 points each).(CD2) for adhesio

40、n molecules, binding with LFA-2, CD3, antigen binding, signal transduction, and representing the total number; CD4,As a marker of Th cell subsets, and bind with MHC class II molecules; CD8, as Tc1 (CTL) and Tc2 (answer Ts cells)Also a marker of subpopulations and binding with MHC class I molecules;

41、CD28, a receptor for costimulatory molecules, that accepts initiation freeThe second signal immune response; the CD40L and its receptor CD40, B cell activation signal to start.Additional instructions: if you answer CD152, CD95, CD95L and so on, each item can also be given 0.5 points.Six. Analysis questions (20 points)Experimental results of killing target cells by 1.NK cells(1) why can NK cells display partial killing function on target cells? Adding anti target cell antibodies can make