天然生物材料体外降解研究

1、天然生物材料体外降解研究天然生物材料体外降解研究research on natural biological mat erials in vitro degradation 王茂秋 0943012030 曾子繁 0943012013王建忠 0943012028 易洪 0943012029一、维普数据库检索检索式：m二(生物+材料)*k二降解检索结果：1/40【题名】热处理刈聚己二酸丁二酯多晶结构和降解行为的影响【作者】赵丽芬1,2蒋妮1甘志华1【刊名】高等学校化学学报.2011,32(1).-185-189【文摘】通过熔融结晶并结合退火处理方法得到多晶结构的聚己二酸丁二酯(pba)及 具冇不同

2、热历史的热力学稳定的«晶型，采用广角x射线衍射仪(waxd)、原子力显微镜 (afm)和差水扫描量热仪(dsc)研究/ pba的多品结构、品体尺寸和结晶形貌，跟踪了 退火处理pba的生物降解行为.结果农明，分子链在相同晶格排列屮i韦i绕c轴空间取向的不 同是决定多晶pba降解速率差别的根本因素.2/40【题名】生物酶降解米糠释放阿魏酸工艺条件优化【作者】王谦李夏兰程珊影方柏山【刊名】华侨大学学报:自然科学版.2011,32(1).-62-66【文摘】采用均匀设计法设计和二次多项式逐步回归分析，优化一株放线菌降解米糠释 放反式阿魏酸的培养基配方，并采用单因索法优化发酵条件.优化后培养基

3、配方：米糠质量 分数为6%,米糠粒径0. 50mm,酵母粉质量分数为1. 0%;优化后的发酵条件：发酵温度为 28°c,摇床转速200r. min-1,装液系数为12%,接种量的体积分数为3. 3%, ph值80.实验结 果表明，反式阿魏酸的释放率最高为14. 55%,与优化前相比，释放率提高了 106. 7%.研究阿 魏酸酯酶和木聚糖酶联合作用于米糠产阿魏酸和低聚糖的协同效应，阿魏酸释放率达到 20.22%,与阿魏酸酯酶单独降解米糠相比，其释放率提高了 119. 1%;低聚木糖的释放量 2. 04mg. ml-l,与木聚糖酶单独降解米糠相比，其释放量提高了 87. 2%.3/40【

4、题名】凝胶渗透色谱法研究壳聚糖生物材料酶降解过程的均匀性【作者】任东文1,2衣洪福1,2谢威扬1马小军1【刊 名】色谱.2006,24(4).-407-410【文摘】壳聚糖是一种重要的牛物医用材料，脱乙酰度是影响其牛物降解性能的重要 因索。运用凝胶渗透色谱研究了脱乙酰度及相对分子质量分布相似、而聚合单元n-乙酰氨 基-1)-衙萄糖和d-氨基荷萄糖分布不同的两种壳聚糖材料在溶菌酶作用下的降解过程，分 析检测了壳聚糖材料在降解过程中的重均和对分子质量、和対分子质量多分散性和相对分 子质量分布的变化。发现聚合单元为随机分布的壳聚糖样品，其降解是均匀的；而聚合单 元为段状分布的壳聚糖样品，-其降解是非

5、均匀的；表明具聚合单元的分布方式决定壳聚糖 材料酶降解过程的均匀性。4/40【题名】脱钙松质骨的骨支架材料制备及英生物学检测【作者】杨渊1林春博1陈维平1,2【刊名】中国组织工程研究与临床康复.2010, 14(47).-8769-8772【文摘】背景：脱钙松质骨的主要成分是胶原，由于具良好的三维空间及促进细胞增殖 分化的生长因子，使其具有传导成骨和诱导成fl的双重功能，但是li前没有修订出一个规范 科学的制备流程。口的：采用新方法制备兔脱钙松质骨,并检测其孔隙率、降解率及其牛 物相容性，对其能否作为组织工程的支架材料进行评估。方法：在urist方法的基础上采 用新方法制备新西兰兔脱钙松质骨，

6、并対脱钙松质骨的空隙率、体外降解率、以及细胞活 力和诱导骨髓间充质干细胞成骨能力进行检测。实验分为脱钙3h,脱钙24h和脱钙48h组, 其他的处理步骤3组都相同。结果与结论：脱钙3, 24, 48h组的孔隙率分别为76. 56%, 81. 25%, 84. 38%。完全降解所需时间分别为64, 59, 53d。细胞在种植后广3d为生长 滞留期，笫5天达到对数生长期，以后进入到平台期。诱导后的骨髓间充质十细胞行碱性磷 酸酶染色呈阳性。结果提示，新方法制备的脱钙松质骨对细胞无讶害作用，在生物学特性上 达到骨组织工程支架材料的耍求。5/40【题名】£-己内酯与i厂丙交酯共聚物降解性能及其生

7、物相容性【作者】高喜翔1张建1陈兵1俞恒锡1李建新1张淑文1孟艳1韩 健2叶霖2冯增国2【刊名】中国组织工程研究与临床康复.2010,14(47).-8791-8794【文摘】背景：£-己内酯与l-丙交酯共聚物具有良好的力学性能，并且降解速率可调 范围大，作为组织工程人工血管材料方面受到人们的青睐。目的：了解£-己内酯与i厂丙 交酯共聚物（pcla）的降解性能及生物相容性。方法：通过调节单体的投料比制备不同组 成、不同和对分子质量的£-己内酯几-丙交酯共聚物，以脂肪酶溶液作为降解液研究共聚 物的降解性能;并且通过体内种植实验研究其工物相容性。结果与结论：己内酯与l

8、-丙 交酯投料摩尔比为75/25的£ 内酯与1厂内交酯共聚物在降解过程屮保持着较高的力学 性能;并且组织相容性好，可用于制备组织工程人工血管。检索式：m二生物材料*降解*u二体外检索结果:6/40【题名】聚碳酸酯型聚氨酯的工物降解性【作者】庚新林1夏维娟1程晓非2吴继功2邹德威2【刊名】中国组织工程研究与临床康复.2010, 14（47）.-8831-8834【文摘】背景：不同聚氨酣材料的生物稳定性差异巨人，研究聚碳酸酯型聚氨酯的生物 稳定性有利于评估其用于人工髓核外囊材料的可行性。口的：观察聚醯型聚氨酯和具有不 同硬段含量的聚碳酸酯型聚氨酯材料的体外和体内降解性能。方法：用模拟环境

9、进行聚氨 酯的体外水解、氧化降解和酶解实验。分别置于37°c恒温的pbs缓冲液和” h202/coc12 预氧化-papain酶解体系”进行体外降解实验。将聚氨酯植入大耳白兔背部肌肉进行体内 降解实验。结果与结论：聚碳酸酯型聚氨酯耐降解性远优于聚储型聚氨酯，口-材料硕段含 呈越人，耐降解性越强。所冇研究结果表明聚碳酸酯型聚氨酯具冇比聚瞇型聚氨酯更加优 越的生物稳定性，对用作较长期人工植入生物材料。7/40【题名】软骨组织工程研究进展【作考】姜疆（综述）1孙杨（综述）2郭树忠（审校）1【刊 名】中国美容医学.2010, 19（4）.-611-614【文摘】软骨组织工程的基本原理是从机体

10、获取少量活组织，将功能细胞从组织中分离 出来,并在体外进行培养、扩增，然后与可降解吸收的支架材料按一定比例混合，植入病损 部位，生物材料在体内逐渐降解和吸收，植入细胞在体内増殖和分泌ecm,最后形成所需的组 织或器官，8/40【题名】生物降解材料对成骨细胞影响的研究进展【作者】陈太勇李开南【刊名】现代临床医学.2009,35(6).-409-411【文摘】生物降解材料是指植入人体以后，能够不断发生降解，降解产物能够被生物 体所吸收或排出体外的一类材料。随着医学以及材料学的发展，尤具是新型材料的研究开 发成功，如20世纪40年代高分子材料的大力发展，为牛物材料的研究-与应用捉供了极大 的发展机会

11、。，目前骨科常用的生物降解材料主要包括犬然高分子材料、9/40【题名】聚乳酸/硅灰石纶物医用复合材料的降解性能【作者】徐梁1熊成东2【刊名】重庆工学院学报：口然科学版.2009,23(3).-69-75【文摘】对聚乳酸/硅灰石这种新型的生物医用复合材料进行了研究。采用溶剂共沉 淀法制备含不同质量分数硅灰石(5%, 10%, 20%和30%)的复合物材料并模压成型， 测圧其力学性能，包括拉伸强度和弯曲强度。结果表明，在聚乳酸基体中加入硅灰石，其 力学性能有所下降，仅当硅灰石质量分数为10%时，拉伸强度略高于纯聚乳酸材料。选取 含硅灰石10%的复合材料放人37.5°c恒温模拟体液中浸泡1

12、, 2, 4, 6, 8, 11, 14, 17, 20, 24及28周，考察其体外降解性能，包插质量损失、体系ph值变化及力学强度的变 化。在降解过程中，聚乳酸/硅灰石复介材料降解速度较慢，并冃保持相对较好的力学性 能，适于应川在骨修复及骨纽织工程领域。10/40【题名】pbte0la共聚酯体内外降解及组织相容性【作者】崔苏萍1王英磊1陈义旺2汪泱1谢安娄1远蕾1朱祥军2【刊 名】江西医药.2009, 44(2).-109-113【文摘】tl的探讨国产生物降解泌尿系支架材料(对苯二甲酸丁二醇酯-co-聚乙二醇- co-低聚乳酸)三元共聚酯(pbte0la)的组织相容性及体内、体外降解特性。方

13、法将 pbteola试件埋植在sd人鼠脊柱两侧皮下组织内或浸泡于磷酸盐缓冲液屮，分别于2、 4、6、8、10、12、14及16周取出.通过组织病理学切片研究材料周围组织反应,利用扫 描啦谴检夏材料的表面征象，准确称垂以检测材料降解前后的垂量。以了解pbteola在体 内、体外的降解情况和组织相容性。结杲pbteola材料在16周内可降解为细小颗粒.材 料的体内、体外降解趋势相同，体内降解速度略快于体外降解。埋植材料周围皮下组织无 脓肿形成和组织坏死发生，局部组织反也为轻微的炎症反应。结论pbteola材料组织相容 性良好，降解时间适宜，适用于制备泌尿系支架，对进一步研究开发。二、中国期刊全文数

14、据库检索检索式：篇名生物+材料+降解并月.主题生物+材料+降解并月.摘要天然+生物+材料+降解检索结果：11/40题乞犬然纤维/可降解塑料生物复合材料研究作者 王云飞;商伟辉;郭云竹;张淑萍；中文摘要木文阐述町完全降解的生物质纤维复合材料的概念,介绍天然纤维/对生物降 解塑料复合材料的制造工艺，研究了原材料天然纤维和可牛物降解塑料的性能及其复合材 料的性能。刊名纤维复合材料年 2010期0412/40题名生物降解高分子材料研究进展作者郝明风;刘勇；丁玉梅;杨卫民；小文摘要介绍了生物降解高分子材料的概念和分类，并结合具体实例详细论述了 li前国 内外在天然、微牛物合成、化学合成和掺混型等四类生物

15、降解高分子材料方血的研究方向 及最新研究进展。刊名工程塑料应用年 2010期0213/40题名天然植物纤维/可生物降解塑料生物质复合材料研究现状与发展趋势作者郭文静; 王正;鲍甫成;常亮；中文摘要由天然植物纤维材料与可生物降解型料复合制备生物质复合材料是木卅纪新 的研究热点，也是复合材料科学发展的必然趋势并具有非常广阔应用前景的完全环境友好 新材料。本文从复合材料的原材料、复合途径、复介材料性能改善及复合机制等方面论述 天然植物纤维/可牛物降解牛物质复合材料的研究现状,并就纶物质复合材料的发展趋势与 前景进行分析。刊名林业科学年 2008期0114/40题名基于天然植物资源的町生物降解聚氨酯材

16、料的制备进展作者闫莉;土晓辉;姚成；中文摘要综述了近年来以天然植物资源为原料制备可工物降解聚氨酯材料的国内外研 究进展;指出利川树皮、甘蔗渣、玉米棒、植物秸秆等天然植物原料液化多元醇制备可生 物降解聚氨酯材料，具有广阔的开发前景。刊名现代化工年 2007期s215/40题名天然牛物可降解材料在牛物医学领域中的应用作者顾伟;刘雷艮;左保齐；中文摘要天然生物可降解材料具有优良的生物相容性，良好的生物力学功能、物理化学 性能、生物性能，且原料来源广泛，目前在生物医学领域得到了广泛应用。本文就应用最广 的丝索、胶原和壳聚糖与甲壳质等儿种主要的可生物降解材料在医学上的用途作一综述。 刊名苏州人学学报（工

17、科版）年 2006期01检索式：主题生物材料并且 关键词一一体外 并且 降解并月.篇名研究检索结果：16/40题名 生物降解微球制剂的体内外相关性研究进展作者李静;苏庆;赵刚；中文关键词中文摘要正叮生物降解注射川微球是近年来发展较快的一种新剂型，它是指利用天然 或合成的高分子材料，将固体或液体药物包嵌成直径为1250 u m的微小球体。该制剂技 术将蛋白和多肽等类药物制备成以微球为载体的长效缓控释制剂。刊名中国页药生物技术年 2011期0117/40题名生物降解性合成高分子材料作为药物缓释载体的研究进展作者杨立群;杨丹;孟舒;关艳嫩;李建新;李淼；中文关键词生物降解性高分了；合成高分了；药物载

18、体；药物缓释体系小文摘要生物降解性合成高分子材料安全、可靠，有良好的生物相容性,成为药物缓释 载体的首选材料。木文简要综述了主要常用的生物降解性合成高分子材料作为药物缓释载 体的研究进展，并对其发展趋势进行了展望。刊名当代医学年 2009期3318/40题名体外研究聚合物p(dlla-co-tmc)的降解性能与释笏行为作者杨丹;杨立群;关艳敏;李淼;李建新;屮文关键词生物相容性材料；药物释放系统；孕二烯酗中文摘要h的研究p(dlla-co-tmc)聚合物的体外降解性能与释药行为，冃探讨该聚介物 作为长效避孕释放载体的可行性。方法以pbs溶液为溶媒研究p(dlla-co-tmc)的降解性能; 以

19、p(dlla-co-tmc)聚合物为载体制备含孕二烯酮的载药片，并通过蒸馆水浸泡载药片研究 载药体系的体外释药彳亍为。结果p(dlla-co-tmc)聚合物前期降解较慢，第30天和第90天 失重率分别为10. 0%和12. 3%,后期降解速率较快，第120天的失重率为59. 3%(dlla-co- tmc) 的载药片前期释药速率较大，出现暴释现象，后期释药速率减缓并逐渐趋于平稳，第 100天时累计释放率为5. 64%o结论p(dlla-co-tmc)聚合物降解性能良好、释药效果明显， 有望通过体内研究使含孕二烯酮的p(dlla-co-tmc)聚介物载药系统应用于长效埋植避孕。刊名中国医药纶物技

20、术年 2009期0419/40题名聚富马酸丙二醇酯/(硫酸钙/b-磷酸三鈣)生物复合材料的体外降解研究作者邸 利芝;刘斌;罗跃娥;赵红;蔡仲雨；中文关键词 聚富马酸丙二醇酯；硫酸钙/0-磷酸三钙；原位成孔；体外降解中文摘要 研究了聚富马酸丙二醇酯/(硫酸钙/b-磷酸三钙)(ppf/(cas04/-3 tcp)生物 复合材料降解过程中，ppf分了量、n-乙烯基毗咯烷酮(nvp)与ppf比例和cas04与b -tcp 摩尔比对复介材料失重、吸水率、溶胀度、抗压强度和模量的影响复合材料的失重、吸 水率和溶胀度随着ppf分子量的增加或nvp/ppf比例、cas04/- 3 tcp摩尔比的降低而降低.

21、降解前后的压缩强度和压缩模虽随着nvp/ppf比例和cas04/ b -tcp摩尔比的降低而升高. 降解42 d后,最大失重、吸水率和溶胀度分别达14. 7%、57. 0%和36. 3%;通过42 d的降解, 所有试样的抗斥模量在57. 0712 mpa,最大抗压强度在3.20. 6 mpa,屈服强度在 0. 1534. 0 mpa.通过sem分析，观察到了 ppf/ (cas04/ b -tcp)复合材料的原位成孔现象.刊名天津理工大学学报年 2009期0320/40题名生物可降解聚丁二酸乙二醇酯的合成与降解性能研究作者刘伟;石峰晖;季君晖;王进锋;李焕新;屮文关键词聚丁二酸乙二醇酯；熔融聚

22、合；生物降解；体外降解屮文摘耍以丁二酸和 乙二醇为原料，直接熔融聚合,合成了高相对分子量的聚丁二酸乙二醇酯(pes),用fttr, 1h- nmr表征其结构;考察了不同聚酯反应催化剂对其聚合反应的影响，结果表明:三氧化二怫的 催化效果是最佳的。同时，利用酶降解和体外水解的方法，对聚合物降解性能进行研究，结 杲表明:pes是一种可生物降解的聚合物,11在体外具有一定的降解性。刊名 塑料年 2008期04三、sci数据库检索检索式:主题=(biological) and 标题=(material*) and 标题二(degradation) 检索结果：21/40au su, wwang, hf f

23、ong, j luo, xh zhang, xz zhuo, rx af su, wei wang, hua-fen feng, jun luo, xiao-hua zhang, xian-zheng zhuo, rerrxi ti novel cationic poly (ester- cocarbonate) materials functionalized with tertiary amine groups新型阳离子聚(酯联合碳酸盐)材料的叔胺官功能so journal of materials chemistryab the current study aimed at design

24、ing cationic and biodegradable biomaterials with improved biological functionality. we report the enzymatic synthesis, characterization and preliminary biological assessment of a series of novel functionalized poly(ester-co-carbonate)s, namely poly(admc-co-cl)s containing tertiary amine groups in th

25、e backbone. the copolymer compositions agreed very we11 with the feed ratios of co-monomers, indicating the excel lent controllability of the preparation method static contact angle measurement revealed that the hydrophilicity of copolymers can be tailored and gradually increased with an increasing

26、admc content in copolymers. with respect to the weight loss, in vitro degradation tests demonstrated the occurrence of lipase- dope ndont，dcgradatio n. copolymers with a higher admc con tent degraded far faster as well. cell proliferation tests suggested that the incorporation of admc in copolymers

27、would considerably promote cell adhesion and proliferation on the polymer surface, indicative of good biocompatibility. as a demonstration of a potential application, poly(admc-co-cl) microspheres were fabricated in an attempt to construct a controlled delivery system for the drug ibuprofen. the sus

28、tained release of ibuprofen loaded in the copolymerswas found to have an evident acceleration in acidic conditions, indicating the ph dependence of such release behavior. sn 0959-9428py 2011vl 21is 17di 10. 1039/c0jm04245eut isi:00028952430003222/40au arwin, iiaf arwin, hans ti application of el 1ip

29、sometry techniques to biological materials椭偏技术的应用生物材料so thin solid filmsab el 1ipsometry is well-suited for bioadsorption studies and numerous reports, mainly using null ellipsometry, are found on this subject whereas investigations addressing structural properties of thin biolayers are few. here tw

30、o examples based on the use of spectroscopic ellipsometry (se) on the latter are briefly discussed. in the first example, time evolution of thickness, spectral refractive index and surface mass density of a fibrinogen matrix forming on a silicon substrate areinvcstigated with se and a structural mod

31、el of the protein matrix is discussed. in the second example a model dielectric function concept for protein monolayers is presented. the model allows parameter!zation of the optical properties which faci1i tates moni tori ng of temperature induced degradation of a prolein layer. more recently， phot

32、onic structures in beetles have been studied with se. it is shown here that full mueller-matrix se can resolve very complex nanostructures in scarab beetles, more specifically chiral structures causing reflected 1ight to become circularly polarized. (c) 2010 elsevier v. al 1 rights reserved.sn 0040-

33、6090pd feb 28py 2011di 10. 1016/j. tsf. 2010. 11.082ut isi:00028917420000523/40au sorkhoh, na a1-awadhi, ii al-mailem, dm kansour, mk khanafer, m radwan, ssaf sorkhoh, n. a. al-awadhi, h. al-mailem, d. m. kansour, m. k. khanafer, m. radwan, s. s.ti agarolytic bacteris with hydrocarbon-uti1ization po

34、tential in fouling material from the arabian gulf coastagarolytic细菌对阿拉伯海湾沿岸污染物质的潜在利用so international biodeterioration & biodegradationab fouling material adhering to a neglected navigation vehicle halfsinking in the coastal water of the arabian gulf harbored two agarolytic bacterial species halo

35、monas aquamarina and alteromonas macleodu with hdrocarbon- ut订ization potential both species were halophilic (optimum 2-5% nacl w/v) slightly alkaliphilic (optimum ph 8) and grew best at 25 degrees c the oil and hydrocarbon consumption polential of both species was dramatically enhanced (2 fold or m

36、ore) by the addition of agar powder to the liquid medium both organisms were able to grow on a nitrogen free medium these resuits imply that such agarolytic bacteria could potentially be suitable biological systems for self-cleaning and bioremediation of oily marine ecosystems (c) 2010 published by

37、elsevier ltdsn 0964-8305pd octpy 2010di 10.1016/j. ibiod. 2010. 06. 007ut isi:000283968700003检索式：主题二(biological*) and 标题二(material*) and 标题二(degradation)检索结果：24/40au vavilin, va fernandez, b palatsi, j flotats, xti hydrolysis kinetics in anaerobic degradation of particulate organic material: an over

38、view有机微粒材料的厌氧降解的动力学水解概述so waste managementab the applicability of different kinetics to the hydrolysis of particulate organic material in anaerobic digestion is discussed. hydrolysis has traditionally been modelled according to the first-order kinetics. for complexsubstrate,the first-order kineticss

39、hould be modified in order to take intoaccount hardly degradable material. it has been shown that models in which hydrolysis is coupled to the growth of hydrolytic bacteria work well at highor at fluctuant organic loading.in particular, the surface-related two-phase and the contois models showed goo

40、d fits to experimentaldata from a wide range of organic waste. both models tend to the first-order kinetics at a high biomass-to-waste ratio and, for this reason, they can be considered as more general models. examples on different inhibition processes that might affect the degradation of solid wast

41、e arc reported acetogenesis or methanogenesis might be the rate-limiting stages in complex waste. in such cases, stimulation of hydrolysis (mechanical 1y, chemical 1y or biologically) may lead to a further inhi bit ion of these stages, which ultimately affects hydrolysis as we 11. since the hydrolys

42、is process is characterized by surface and transport phenomcma, now developments in spatially distributed models are considered fundamentql to provide new insights in this complex process- (c) 2007 elsevier ltd. all ri ghts reserved.sn 0956-053xpy 2008di 10. 1016/j. was man. 2007. 03. 028ut 1st:0002

43、5546760000225/40au radin, s falaize, s lee, mh ducheyne, pti application of ellipsometry techniques to biological materials 二氧化硅干 凝行为作为控释材料在体外的生物活性和降解衣现so biomaterialsab room temperature-processed silica-based sol-gel, termed silica xerogel, is a novel type of controlled release material. as shown p

44、reviously, these materials are porous, degradable and can release biologically functional molecules in a controlled mannor. it was also demonstrated that these materials are biocompatible in vivo. herein we report on the ability of silica-based xerogels to form a bioactive, apatite-like (ap) surface

45、 and the effect of ap surface on the xerogel stability in vitro. formation of a crystalline, carbonated ap (c-ap) was found on all silica xerogels studied, with or without ca- and p-oxides. calcium and phosphate (ca-p) free xerogels showed long times to ca-p precipitation and to formation of a detec

46、table ap- 1ayer (lip to 2 weeks). tn contrast, the times to precipitation were reduced by 2-3 orders of magnitude, and the c-ap layer was formed within 24 h on all ca-p containing xerogels. mechanisms of the c-ap formation on these xerogels were si mil ar to those typical for ca-p based ceramics: di

47、 ssolution of calcium and phosphate ions, solution oversaturation with respect to ap and subsequent precipitation of bone-like minerals. the presence of the c-ap surface film produced a remarkable surface stabilizing effect: the rates and the amounts of si release were significantly reduced in compa

48、rison to those for xerogels without the film this evidenee of in vitro bioactivity and controlled degradation, combined with previous in vitro and in vivo reports, suggests that silica xerogel is a promising controlled release material. (c) 2002 elsevier science ltd. all rights reserved.sn 0142-9612

49、pd augpy 2002ut isi:000176268800006四、el数据库检索检索式：(biological materials) wn ky) and(degradat*)wn ky) and(research)w ky)检索结果：26/40 research on rheological and thermal properties of p(3iib-4iib)/peg and the preparation for fiber关于p (3iib - 4iib) /聚乙二醇的流变学性质和热学性质与制备纤维束的研究guo, jingl; zheng, nani; zhang, s

50、en2 source: advanced materials research, v 152-153, p 1611-1615, 2011, new materials and advanced materials; conference: 2010 internalional conference on advances in materials and manufacturing processes, icammp 2010, november 6,2010 - november & 2010; sponsor:university of wollongong (uow); nor

51、theastern university (nu); university of science and technology beijing (ustb); hebei polytechnic university (hpu); hong kong industrial technology research centre (1trc); publisher: trans tech publicationsabstract: 3-hyclroxybutyrate-co-4-hydroxybutyrato p(3hb-4hb) is ono of polyhydroxyalkanoates w

52、hich is biodegradable and biocompatible, and is one of the hot issues of the biodegradable materials research but the degradation will occur at high temperature and shear rate. so p(3hb-4hb) is modified withpeg10000 by means of a mochanical blending. in this research, capillary rheometer and tga are

53、 applied to investigate its rheological and thermal behaviors. the technology of melt spinning is also studied and the p(3iib- 4hb)/peg10000 fiber with a certain mechanical property is obtained successfully. electronic velocimeter and electronic single end yarn strength tester are applied to investi

54、gate the mechanical property of the fiber. the result of tg indicates that the addition of peg10000 improves the thermal stability of p(3iib-4iib). the result of cap订lary rheometer shows that p(3iib- 4hb)/peg10000 is pseudoplastiefluid. because of the addition of peg10000, the non-newtonian index n

55、of the p(3hb-4hb)/igioooo sample increases and the flow activation energy of the p(3iib-4hb)/peg10000 sample decreases. the result of fiber strength test shows that the addition of peg10000 has an impact on the mechanical property of the fiber and the lowest fiber strength appeared when peg10000 con

56、tent was p(3hb-4hb)/peg=100/6. the moisture regain ratio increases with the content of peg10000 rising. and when peg10000 content is p(3hb- 4hb)/peg=100/2, the highest degree of orientation of fiber appears. © (2011) trans tech publications, switzerland. (4 refs.)27/40ex vivo and in vitro synch

57、rotron-based micro-imaging of biocompatible materials applied in dentai surgery在体内和体外同步为基础的微型牙科手术中的应用生物相容性材料成像rack, a. 1; stiller, m. 2; nelson, k. 2; knabe, 0. 2; rack, t. 2; zabler, s. 3; dalugge, 0.2; riesemeier, h4; cecilia, a. 5; goebbels, j. 4 source: proceedings of spie - the international so

58、ciety for optical engineering, v 7804, 2010, developments in x-ray tomography vii; issn: 0277786x; isbn-13: 9780819483003; d01: 10.1117/12. 858435; article number: 78040e; conference: developments in x- ray tomography vii, august 2, 2010 - august 5, 2010; sponsor: the society of photo-optical instrumentation engineers (spie); publisher: spieabstract: biocompatible materials such as porous bioactive calcium phosphate ceramics or titanium are regu