关于性别对哮喘发病年龄的影响

1、关于性别对哮喘发病年龄的影响关于性别对哮喘发病年龄的影响 日期：7刀10 h【性别性别对哮喘患者发病年龄的影响【文摘目的摘要:探讨性别对哮喘病人的发病年龄的影响o方法摘要: 进行问卷调查在230年一生不吸烟的哮喘病人先后加入了呼吸道医 学系和儿科医院从2003年3月至12月。这些病人被要求回答包括年 龄、性别、第一次喘息的时间、慢性咳嗽的存在以及持久性的问题。 结果摘要:在226例合格的问卷调查,89名患者（39%）显示慢性持续性 咳嗽之前首先出现气喘、慢性咳嗽的发病率在女性哮喘病人明显高于 男性（47. 4% vs 33. 6%, x 2 二 4 38, p % 26 lt;0. 05） o

2、 哮喘的症状， 包括慢性咳嗽和喘息，在女性中（中值为29岁）比男性（中值为13岁） 出现。慢性咳嗽患者的年龄越小，在第一次哮喘发作前的慢性咳嗽时 间就越短（rs=0. 60213, p二0.0001）。结论摘要:有一个显著的年龄差 异发展的两性之间的哮喘。性荷尔蒙可能在哮喘的发病机制中起着重 要作用。关键词哮喘;慢性咳嗽;男性;女性;喘息；问卷调查【摘要目的摘要:探究支气管哮喘患者首次喘息以及首次喘息以前慢 性咳嗽的发病年龄和性别差异。方法摘要:选择200303/200312期间 我院呼吸科和儿科门诊就诊及住院的连续230例不吸烟的普通哮喘 患者，进行临床问卷调查。问卷的内容包括性别,年龄,首

3、次喘息发作 时间，首次喘息发作前有无慢性咳嗽，慢性咳嗽的持续时间等。结果摘 要:在226份有效调查问卷中，女性慢性咳嗽高峰出现在成年后（中位 数29岁），男性发病高峰则在幼儿期（中位数为13岁）。哮喘患者发病 年龄和首次喘息前的慢性咳嗽时间呈正相关(r二0. 60213, p二0. 60213),女性慢性咳嗽的发病率较男性高(两者分别为47. 4%和33. 6%, x 2 = 4. 3 &p % 26 lt;0. 05) o结论摘要:在哮喘的发病年龄 上,存在明显的性别差异。性激素可能在哮喘的发病中起到一定的功 能。【哮喘;慢性咳嗽;男性;女性;喘息；问卷调查0引言喘息和慢性咳嗽是哮喘

4、的主要症状。多数资料认为哮喘各年龄段均可 发病，男女无显著差异1,然而也有学者认为男女哮喘发病年龄不同 2 -3,绝经后激素替代治疗者哮喘发病率增高4。因此，哮喘的发 病是否存在性别和年龄差异，目前尚无定论。我们通过问卷调查，试图 对哮喘的发病年龄和性别差异进行探究。1对象和方法lo1 object choice 200303/200312 department of respiratory medicine and pediatric outpatient and hospitalization (male 131, female 131) in 226 consecutive patien

5、ts not smoking, asthma, aged 3 、 76 (38 + 18), asthma course of 0. 5 ' 68 a. all object conforms to the chinese medical association respiratory branch issued the diagnosis of bronchial asthma prevention guide to determine the standard 5, a recurrent wheezing clinical cough lasts 3 wk judged to b

6、e a chronic cough or 6method of inquiry into the medical history of the patient the age of the first wheezing; (3) for the first time before the on set of breathing prese nee of chro nic cough if yes, then ask cough duration. as much as possible to ensure the accuracy of the survey and objectivity,

7、questionnaire related content by trained and accepts doctors don，t know to explore the purpose of item by item, fill in, and then to review was conducted in 10% of patients by another physician. in the recovery of 230 questionnaires in four copies of questionnaires (3 male, 1 female) for leakage cou

8、gh was excluding duration and contact phone number, and 226 effective questionnaires statistical processing abstract: to analyze the re leva nt data to effective questionnaire survey, statistical analysis using chi-square test to count data, measurement data using t test or nonparametric statistics,

9、 for chronic cough time coughing and wheezing onset age kendall correlation analysis application sas6.12 statistic software p 0. 05 showed statistically significant difference2 the results2. 1 before the first break the incidence of chronic cough asthma patients gender differences between men and wo

10、men the incidence of chronic cough were 47. 4% (45/95) and 33. 6% (44/131), before the first break of asthma patients with chronic cough frequency is higher than male (chi-square 二 4. 3& p % 26 it; 0. 05), the former is 1.41 times of the latterthe gender difference in the age of onset of asthma2

11、. 2. 1 different sex for the first time for breath before the onset of chronic cough asthma patients age difference before the first break in 89 cases with chronic cough asthma, men and women age distribution difference (chi-square 二 0.25, p % 26 gt; 0. 05, table 1). but the onset of chronic cough i

12、n different age (chi-square 二 6. 029, p % 26 it; 0. 05), the male onset age, 54. 5% of men appeared before the first break of chronic cough younger than 16 years of age, the median is 13 years old; for women with age, 66. 7 per cent of women with asthma had a chronic cough from 16 to 50 years of age

13、, with the median age of 29 (table 2).table 1: the gender and age composition of patients with chronic cough asthma (abbreviated)the gender differences in the age of chronic cough (abbreviated) for the first wheezing of asthmatic patientsfirst break 2.2.2 asthma onset age of gender differences and s

14、ex differences in on set age similar to tha t of chronic cough in patients with asthma, 226 cases of normal, men and women into the age group there was no significant difference (chi-square 二 1. 324, p 二 1. 324, table 3), but for the first time of wheezing onset age have significant gender differenc

15、e (chi-square 二 5.062, p 二 5.062). the younger male patients with asthma breathing happen, people under 16 (48.9%), the median is 18 years old; women were more likely to be in the middle of the period, with 66. 3 percent of those aged 16 to 50, and 29 years old (table 4).patients with asthma were af

16、fected by the first wheezing of chronic cough 2.3.1 gender before the first break time of chronic cough in patients with asthma effects of male patients with asthma chronic cough before first break of 0.8 240 mo median (m 二 8); the duration of the cough duration for women was 1 216 (m 二 3), but for

17、the first time, there was no significant difference in the duration of the cough duration (p % 26gt;0. 05)table 3 asthma patients， gender and age composition (abbreviated)the gender differences (abbreviated) for the first wheezing age of asthmatic patients2. 3. 2 chronic cough and the relationship b

18、etween the onset age of chronic cough time is skewed distribution (0.8 240 mo, m 二 4 mo), the onset of chronic cough age was also skewed distribution (059, a 二 20), chronic coughing and wheezingonset age for the first time and duration of cough was positively rank correlation (rs 二 0.60213 and rs 二

19、0.59470, respectively, both p 二 0.0001).the group of chronic cough asthma symptoms of chronic cough and breathing space for the first time the older you get, the longer the chronic cough, wheezing onset age and chronic cough onset age without rank correlation (rs 二 0.06400, p 二 0.06400)3 discusswe f

20、ound that women with asthma first break before the prevalence of chronic cough than men, and coughing and wheezing onset age than men, the peak appeared in adult but first break old chronic cough time is not, affected by gender the first break previous chronic cough time all along with the increase

21、of onset age and extended3. 1 proactive in the relevant test design although this inquiry, but the data collected for retrospective therefore, in the data collection process can，t rule out a possible deviation of information, such as memory bias however, the sample size is larger, the inquiry includ

22、ing asthma patients of all ages the sample collection of continuity, to avoid the artificial selection bias all the cases were diagnosed with asthma standards, at the same time, the related content of questionnaire by trained and accepts doctors don，t know to explore the purpose of item by item, fil

23、l in, and then to review was conducted in 10% of patients by another physician, thus as far as possible to ensure the data accuracy and objectivity in addition, a large number of domestic reports now adolescence have advance toward 7, so we advance the division standard of adults to the age of 16, m

24、ay be more in line with the actual situation.3. 2 sex for the first time in patients with chronic cough asthma and wheezing breath in front of the chronic cough cough variability asthma is the most likely or acidophilus granulocyte bronchitis, is an early stage of asthma 8 this result shows that wom

25、en before the first break of chronic cough in patients with asthma prevalence was 1. 41 times that of male sex may prompt is one of the factors impact of chronic cough in addition, the onset of asthma symptoms between age there are significant differences, chronic coughing and wheezing onset age, me

26、n and women come on older, and foreign coverage of the female adult higher 9 the incidenee of chronic cough, asthma symptoms occur in adolescence, while men are occurred before adulthood of the 10-11 which is consistent with the experimental results see more women than men are asthma patients with c

27、hronic cough, cough may and female sensitivity high. because of the healthy women reported by capsaicin, tartaric acid 12 or 13 the cough reflex induced by high than men, women with chronic cough capsaicin and citrate cough reflex sensitivity is about twice as many men 10 this difference can quickly

28、 adapt to the stretch receptor and women airway and c afferent nerve fibers are easy to irritability or their psychological quality is different from male 14 female patients with chronic cough and asthma wheezing onset age big than men, may be caused by the sex hormones of different sexes, because t

29、his inquiry is not smoking as one of the criteria for the patients with asthma, smoking on chronic cough have been ruled out the influence of gender differences, but the effect of sex hormone is yet to be further explored3.3 chronic cough to breathing before first break time is affected by the on se

30、t age about a third of the common existence in the first breath of chronic cough in patients with asthma, cough duration with the increase of onset age and extended the degree of airway obstruction and airway inflammation intensity and number of smooth muscle contraction ability or related 15, the d

31、egree of airway obstruction. 16 impact of chronic cough time after respiratory syncytial virus infection in the devel opine nt stage of children，s respiratory tract increased the expression of substance p and corresponding nk1 receptors, nervous system amplifies the airway inflammation 17, high degr

32、ee of airway obstruction and chronic cough faster into the breathing sen订e cerebrovascular diseases and degenerative diseases of the nervous system increase, airway smooth muscle contraction in 18, the degree of airway obstruction light, so chronic cough to breathing long time above all, our results

33、 showed that sex is one of the important factors affecting asthma onset age, sex hormones may play a function in the pathogenesis of asthmathanks to our pediatric xing-yuan liu, zheng huifen physicians, respiratory zhong-min yang, wang lan, zhang min, yuli and liu ruilin physician to complete the co

34、llection of part of the questionnaire, chun-bo li, an associate professor and dr lanyang respectively offer a great help in medical statistics and english writing【reference_1, 1. , et al. internal science m6 beijing abstract: people* s health press, 2001:82.the characteristics of the study are publi

35、shed in the journal of the international journal of human history.3 cagney m, macintyre cr, mcintyre pb, et al. childhood asthma diagnosis and use of asthma medication j.ool, 2000, 34 (3): 193-196. _4barr rg, wentowski cc, grodstein f, et al. a prospective study of postmenopausal hormone use and new

36、ly diagnosed asthma and chronic obstructive pulmonary diseases j arch intern med, 2004, 23. 164 (4) abstract: 379-386.5 the respiratory branch of the chinese medical association. the guidelines for the prevention and control of bronchial asthma j china tuberculosis and respiratory journal, 2003, 26

37、(10) : 132-138.the diagnostic protocol in chronic cough with specific reference to gastroesophageal reflux disease j am j med, 2000, 108 abstract: 126s - 130s._7 owe just zhuang, zhao wenyao ma zuyan, etc. yimeng mountain area healthy adolescent adolescence sexual development condition investigation j chinese journal of practical pediatrics, 2001: abstract: 154-156the study of c