当今干细胞研究方面地10位顶尖科学家

1、标准文档排名第一： Shinya Yamanaka 禾口 JamesA.Thomson博士是建立了可诱导的万能干细胞, 在干细胞再生和分化重排机理上做出了最具突破性的进展性工作；这毫无疑问是诺贝尔奖级的工作, 其他几位 平时工作很杰出,可是没有这种级别的工作,只好屈居次位；排名第二： Rudolf Jaenisch 博士长期从事于干细胞核的替代重组和干细胞的表观遗传修饰工作, 卓有成 绩,这也是培养诱导干细胞的核心工作,重要性无人能代替；排名第三： Rebort lanza 博士领导和指挥着全球最领先的干细胞生物技术公司, 独创和建立了别离和 培养单个胚胎干细胞的方法和技术.主编了所有重要的干

2、细胞参考书 籍.每一相重大干细胞技术的出现,美欧主流媒体都要听他的意见,可 谓干细胞领域的大腕人物；排名第四： Alan Trounson 博士是国际免疫学和干细胞研究的先驱者,领导和指挥原澳大利亚 Monash 大学免疫学和干细胞研究实验室,使 Monash 大学成为世界上最成功的 大学之一.手下的弟子 Martin Perl 博士出任南加州大学第一界干细胞 和系统生物学所所长. 2007 年成为美国眼下资金最多, 实力最强的加州 再生医学研究研究所所长,成为美国干细胞研究中最大的老板； 排名第五：哈佛大学干细胞研究所所长 Douglas A. Melton 博士和斯坦 福大学干细胞和再生医

3、学研究所所长 Irving L. Weissman 博士 两人都是干细胞研究领域的顶尖高手, 又各了带着着东西两岸这两所美 国奈至全世界的顶尖学府的干细胞研究的竟赛. 排名第六：哈佛大学干细胞研究所共同所长 David T. Scadden, 博士 和密西根大学干细胞中央主 Sean Morrison 博士 两人是干细胞研究的中青年骨干, 专长于干细胞分化再生的微环境调 控机理的研究, . Scadden, 博士是 麻省总医院再生医学研究所所长, 侧重于干细胞的临床应用. Morrison 博士那么是休斯医学研究所研究员, 是美国中西部大学中干细胞研究的顶级人物.排名第七到第十的是国际上知名的

4、干细胞专家, 包括爱丁堡大学克隆 了多利羊的 Wilmut 教授,皮肤毛发干细胞再生医学领军人物 Fuchs 教 授和把干细胞用于临床治疗的先锋人物瑞典的 Lindvall 教授,以及华 人中干细胞研究的顶尖人物, 由中国人出任的耶鲁大学干细胞中央主任 林海帆教授.第一位：Shinya Yamanaka, Ph.D.日本京都大学前沿医学研究所干细胞生物学系,加州大学旧金山分校心血管疾病研究所教授代表作文章1. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, TomodaK, Yamanaka S.Induction of pluri

5、potentstem cells from adult humanfibroblastsby defined factors. Cell . 2007 Nov 30;131(5):861-72.2. Okita K, Ichisaka T,Yamanaka S.Generationofgermli ne-compete nt in duced pluripote nt stem cells.Nature . 2007 Jul 19;448(7151):313-7.3. NakagawaM, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, AoiT,

6、 Okita K, Mochiduki Y, Takizawa N,Y ama naka SGe neration ofin duced pluripote nt stem cells without Myc from mouse and huma n fibroblasts.Nat Biotech nol . 2007 Nov 30;4. Takahashi K, Yamanaka Sinduction of pluripotent stem cellsfrom mouse embry onic and adult fibroblast cultures by defi ned factor

7、s. Cell . 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10.5. Takahashi K, Ichisaka T,Yamanaka S. Identification of genesinvolved in tumor-like properties of embryonic stem cells. Methods Mol Biol . 2006;329:449-58.并列第一位 ：JamesA.ThomsonPh.D. 威斯康星大学基因组研究中央主任,解剖学系教授代表作文章1. Yu J, Vodyanik MA, Smuga-Otto K,

8、Antosiewicz-Bourget J, FraneJL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, SlukvinII, Thomson JA.Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells .Science . 2007 Nov 202. Ludwig TE, Bergendahl V, Levenstein ME, Yu J, Probasco MD, Thomson JA.Feeder-independent culture of h

9、uman embryonic stem cells.Nat Methods . 2006 Aug;3(8):637-463. Ludwig TE, Levenstein ME, Jones JM, Berggren WT, Mitchen ER, Frane JL, Crandall LJ, Daigh CA, Conard KR, Piekarczyk MS, Llanas RA, ThomsonJA.Derivation of humanembryonic stem cells in defined conditions.Nat Biotechnol . 2006 Feb;24(2):18

10、5-7.4. Yu J, Vodyanik MA, He P, Slukvin II, Thomson JA.Humanembryonic stem cells reprogram myeloid precursors following cell-cell fusion.Stem Cells . 2006 Jan;24(1):168-76. Epub 2005 Oct 65. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, JonesSB, Brooks JD, Andrews PW, Brown PO , Thomson JA

11、.Gene expression patterns in humanembryonic stem cells and human pluripotent germ cell tumors.Proc Natl Acad Sci U S A.2003 Nov 11;100(23):13350-5.第二位：Rudolf Jaenisch MD ,麻省理工学院白头生物研究所教授代表作文章1. Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, CassadyJP, Beard C, Brambrink T, Wu LC, Townes TM, Ja

12、enisch R.Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin.Science . 2007 Dec 6 ；2. Meissner A, Wernig M, Jaenisch R.Direct reprogramming of genetically unmodified fibroblastsinto pluripotent stem cells.Nat Biotechnol . 2007 Oct;25(10):1177-81 ；3. Wernig M, Me

13、issner A, ForemanR, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R.In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.Nature . 2007 Jul 19;448(7151):318-24 ；4. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray

14、 MK, Bell GW,Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R.Polycomb complexes repress developmental regulators in murine embryonic stem cells.Nature . 2006 May 18;441(7091):349-53 ；5. Meissner A, Jaenisch R.Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient b

15、lastocysts.Nature . 2006 Jan 12;439(7073):212-5 .第三位 ： Rebort lanza Ph.D. 麻省先进细胞公司首席科学家,北卡州Wake Forest 大学医学院教授1. Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R.Humanembryonic stem cell lines derived from single blastomeres.Nature . 2006 Nov 23;444(7118):481-5.2. Lu SJ, Feng Q, Caballero S, Chen Y,

16、 Moore MA, Grant MB, Lanza R.Generation of functional hemangioblasts from humanembryonic stem cells.Nat Methods . 2007 Jun;4(6):501-93. Chung Y, Klimanskaya I, Becker S, Marh J, Lu SJ, Johnson J, Meisner L, Lanza R.Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres.Na

17、ture . 2006 Jan 12;439(7073):216-9.4. Lanza RP, Chung HY, Yoo JJ, Wettstein PJ, Blackwell C, BorsonN, Hofmeister E, Schuch G, Soker S, Moraes CT, West MD, Atala A.Generation of histocompatible tissues using nuclear transplantation. Nat Biotechnol . 2002 Jul;20(7):689-96.5. Lanza RP, Cibelli JB, Blac

18、kwell C, Cristofalo VJ, Francis MK,Baerlocher GM, Mak J, Schertzer M, Chavez EA, Sawyer N, LansdorpPM, West MD. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science. 2000 Apr 28;288(5466):665-9第四位 ：Alan Trounson Ph.D. 加州再生医学研究研究所所长, 教授(原 澳大利亚Mon ash

19、大学免疫学和干细胞研究实验室主任)代表作文章1. GQDaley, L AhrlundRichter,JM Auerbach, NBenvenisty, RACharo, G Chen, HKDeng,LS Goldstein, KL Hudson, I Hyun, SC Junn, J Love, EH Lee, A McLaren, CL Mummery,N Nakatsuji, C Racowsky, H Rooke,J Rossant, HR Scholer, JH Solbakk, P Taylor, AOTrounson, IL Weissman, I Wilmut, J Yu,

20、L Zoloth (2007) The ISSCR Guidelines for HumanEmbryonic Stem Cell Research. Science 315: 603604. 303.2. A Giudice and A Trounson (2007) Genetic manipulation of humanembryonic stem cells for cell based therapy.Nature Biotech ；3. M Snow, SL Cox, G Jenkin, A Trounson, J S h aw(2002) Generation of live

21、young from xenografted mouse ovaries. Science 297: 2227.4. BE Reubinoff, MF Pera, CY Fong, A Trounson , A Bongso (2000)Embryonic stem cell lines from human blastocysts:somaticdifferentiation in vitro. Nature Biotechn . 18: 399404.5. AT Dowsing, EL Yong, M Clark, RI McLachlan, DM de Kretser, Trounson

22、 (1999) Linkage between male infertility trinucleotide repeat expansion in the androgen receptor gene. Lancet 354: 640643.第五位：Douglas A. Melton, Ph.D,哈佛大学干细胞研究所所长, Hughes Medical Institute研究员.代表作文章1. Stanger BZ, Tanaka AJ, Melton DA .Organ size is limited by the number of embryonic progenitor in the

23、 pancreas but not the liver.Nature . 2007 Feb 22;445(7130):886-91.2. Cowan CA, Atienza J, Melton DA , Eggan K.Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.Science. 2005 Aug 26;309(5739):1369-73.3. Dor Y, Brown J, Martinez OI,Melton DA.AOandHowardcellsratherAdul

24、t pancreatic beta-cells are formed by self-duplication than stem-cell differentiation.Nature . 2004 May 6;429(6987):41-6.4. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA .Insulin staining of ES cell progeny from insulin uptake.Science . 2003 Jan 17;299(5605):363.5. Ramalho-Santos M, Yoon

25、S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": transcriptional profiling of embryonic and adult stem cells.Science . 2002 Oct 18;298(5593):597-600.并列第 5 位 Irving L. Weissman MD. 斯坦福大学干细胞和再生医学研 究所所长代表作文章1. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, WeissmanIL "Defi

26、ciencies in DNAdamagerepair limit the function of haematopoietic stem cells with age." Nature 2007; 447: 7145: 725-92. Forsberg EC, Serwold T, Kogan S, Weissman IL , Passegu eE. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.Cell.

27、 2006 Jul 28;126(2):415-263. Laird DJ, De Tomaso AW, Weissman IL.Stem cells are units of natural selection in a colonial ascidian.Cell . 2005 Dec 29;123(7):1351-604. De Tomaso AW, Nyholm SV, Palmeri KJ, Ishizuka KJ, LudingtonWB, Mitchel K, Weissman IL .Isolation and characterization of a protochorda

28、te histocompatibility locus.Nature . 2005 Nov 24;438(7067):454-95. Passegu eE, Wagner EF, Weissman IL .JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.Cell. 2004 Oct 29;119(3):431-43.第六位 ：David T. Scadden, M.D.Director, Center for Regenerative Medicine, M

29、assachusetts General Hospital , Co-Director, Harvard Stem Cell Institute, Harvard University .麻省总医院再生医学研究所所长, 哈佛大学干细胞研究所共同所长代表作文章1. Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT.Stem-cell ageing modified by the cyclin-dependent kina

30、se inhibitor p16INK4a.Nature . 2006 Sep 28;443(7110):421-6.2. Scadden DT.The stem-cell niche as an entity of action.Nature . 2006 Jun 29;441(7097):1075-9 ；3. Adams GB,Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT.Stem cell engraftment at th

31、e endosteal niche is specifiedby thecalcium-sensing receptor.Nature . 2006 Feb 2;439(7076):599-603 ；4. Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, AdamsGB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL.Oocyte generation in adult mammalian ovari

32、es by putative germcells in bone marrow and peripheral blood.Cell. 2005 Jul 29;122(2):303-155. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, KnightMC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA,Kronenberg HM, Scadden DT.Osteoblastic cells regulate the haematopoietic stem cell

33、 niche.Nature. 2003 Oct 23;425(6960):841-6 . 并列第六位Sean Morrison, PhD 密西根大学干细胞中央主任 Director, Center forStem Cell Biology, University of Michigan , Howard Hughes Medical Institute, USA代表作文章1. Morrison SJ, Spradling AC. Stem cells and niches: mechanismsthat promote stem cell maintenance throughout life

34、.Cell . 2021Feb 22;132(4):598-6112. Kiel MJ, He S, Ashkenazi R, Gentry SN, Teta M, Kushner JA,Jackson TL, Morrison SJ. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.Nature. 2007 Sep 13;449(7159):238-42.3. Kim I, Saunders TL, Morrison SJ.Sox17 dependence disting

35、uishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell . 2007 Aug 10;130(3):470-83.4. Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ.Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis durin

36、g ageing. Nature . 2006 Sep 28;443(7110):448-52.5. Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ.Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature . 2006 May25;441(7092):475-82.第七位 George Daley, M.D., Ph.D 哈佛大学干细胞研究所, 波士顿儿童医院教授代表

37、作文章1. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, LerouPH, Lensch MW, Daley GQ.Reprogramming of humansomatic cells to pluripotency with defined factors.Nature . 2021 Jan 10;451(7175):141-6.2. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, BowmanTV, Jang IH, Gr

38、osser T, Fitzgerald GA, DaleyGQ, Orkin SH, Zon LI.Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.Nature . 2007 Jun 21;447(7147):1007-113. Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, L

39、ee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L.Ethics. The ISSCR guidelines for human embryonic stem cell research.Science . 2007 Feb 2;315(5812):603-4 ；4. Kim K, Lerou P, Yabuuc

40、hi A, Lengerke C, Ng K, West J, KirbyA, Daly MJ, Daley GQ.Histocompatible embryonic stem cells by parthenogenesis.Science . 2007 Jan 26;315(5811):482-6 ；5 Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ. Derivation of embryonic germ cells and male gametes from embryonic stem cells.Nature

41、 . 2004 Jan 8;427(6970):148-54.并列第七位Fred H. Gage, PhD, Salk Institute for Biological Studies , California, USA 美国加州索克生物研究所教授代表作文章1.Zhao C, Deng W, Gage FH.Mechanisms and functional implications of adult neurogenesis.Cell . 2021 Feb 22;132(4):645-60 ；2. Zhang CL, Zou Y, He W, Gage FH, Evans RM.A role

42、 for adult TLX-positive neural stem cells in learning and behaviour.Nature . 2021 Feb 21;451(7181):1004-7.3. Tashiro A, Sandler VM, Toni N, Zhao C, Gage FH.NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus.Nature. 2006 Aug 24;442(7105):929-33.4. Muotri AR, Gage

43、FH.Generation of neuronal variability and complexity.Nature. 2006 Jun 29;441(7097):1087-93.5. Lie DC, Colamarino SA, Song HJ, Ddsir eL, Mira H, ConsiglioA, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH.Wnt signalling regulates adult hippocampal neurogenesis. Nature.2005 Oct 27;437(7063):1370

44、-5第八位Alan Colman , Ph.D. director of stem-cell research at King'sCollege London , UK代表作文章1. Colman A.Everyone listed on Dolly paper met established criteria for authorship.Nature. 2006 Apr 27;440(7088):1112；2. Buzzard JJ, Gough NM , Crook JM, Colman A.Karyotype of human ES cells during extended

45、culture.Nat Biotechnol . 2004 Apr;22(4):381-2;3. Polejaeva IA, Chen SH, Vaught TD, Page RL, Mullins J, Ball S,Dai Y, Boone J, Walker S, Ayares DL, Colman A, Campbell KH.Cloned pigs produced by nuclear transfer from adult somatic cells.Nature . 2000 Sep 7;407(6800):86-90.4. Gurdon JB, Colman A.The fu

46、ture of cloning.Nature . 1999 Dec 16;402(6763):743-6.5. Colman A, Kind A.Therapeutic cloning: concepts and practicalities.Trends Biotechnol . 2000 May;18(5):192-6并列第 8 位 Fiona Watt, DPhil , ancer Research UK, Cambridge Research Institute , UK1. Watt FM, Frye M, Benitah SA.MYC in mammalian epidermis:

47、 how can an oncogene stimulate differentiation?Nat Rev Cancer . 2021 Mar;8(3):234-42.2. Takeda H, Lyle S, Lazar AJ, Zouboulis CC, Smyth I, Watt FM.Human sebaceous tumors harbor inactivating mutations in LEF1.Nat Med. 2006 Apr;12(4):395-7.3. Benitah SA, Frye M, Glogauer M, Watt FM.Stem cell depletion

48、 through epidermal deletion of Rac1.Science . 2005 Aug 5;309(5736):933-5.4. Watt FM, Hogan BL.Out of Eden: stem cells and their niches.Science . 2000 Feb 25;287(5457):1427-30.5. Gandarillas A, Watt FM.c-Myc promotes differentiation of human epidermal stem cells.Genes Dev. 1997 Nov 1;11(21):2869-82.第

49、9位Ian Wilmut, PhD, DSc英国爱丁堡大学再生医学中央教授,Universityof Edinburgh , Scottish Centre for Regenerative Medicine, UK1. Wilmut I, Taylor J.Stem cells: primates join the club.Nature . 2007 Nov 22;450(7169):485-6.2. ilmut I, West MD, Lanza RP, Gearhart JD, Smith A, Colman A,Trounson AO, Campbell KH.Human embry

50、onic stem cells.Science. 2005 Dec 23;310(5756):1903. Epub 2005 Dec 13.3. Wilmut I, Beaujean N, de Sousa PA, Dinnyes A, King TJ, PatersonLA, Wells DN, Young LE.Somatic cell nuclear transfer.Nature . 2002 Oct 10;419(6907):583-6.4. Ashworth D, Bishop M, Campbell K, Colman A, Kind A, SchniekeA, Blott S,

51、 Griffin H, Haley C, McWhir J, Wilmut I.DNA microsatellite analysis of Dolly.Nature. 1998 Jul 23;394(6691):329 .5. Campbell KH, McWhir J, Ritchie WA, Wilmut I.Sheep cloned by nuclear transfer from a cultured cell line.Nature. 1996 Mar 7;380(6569):64-6.并列第 9 位Elaine Fuchs, PhD Rockefeller University,

52、 Howard Hughes MedicalInstitute , USA美国洛克菲勒大学教授, 休斯医学研究所研究员.代表作文章1. Yi R, Poy MN , Stoffel M, Fuchs E.A skin microRNA promotes differentiationby repressing 'stemness'.Nature. 452(7184):225-9 .2021 Mar 13;2. Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E.NFATc1balances quiescence and

53、 proliferation of skin stem cells. Cell. 2021 Jan 25;132(2):299-310.实用大全标准文档3. Nguyen H, Rendl M, Fuchs E.Tcf3 governs stem cell features and represses cell fate determination in skin.Cell. 2006 Oct 6;127(1):171-83.4. Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E.Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.Cell . 2006 Aug 11;126(3):597-6095. Perez-Moreno M, Davis MA