中科院深圳先进技术科学院接受客座学生专业

1、中国科学院深圳先进技术研究院导师简况表导师姓名万晓春性别男职称研究员专业名称免疫学导师类别博导 硕导所在单元医药所抗体药物研究中心是否兼职是 否招生专业物理化学（含化学物理）生物化学与分子生物学信号与信息处理模式识别与智能系统计算机应用技术材料工程电子与通信工程控制工程计算机技术生物工程研究方向抗体药物研发免疫细胞信号传导炎症/自身免疫性疾病及癌症的治疗在研课题无。个人简历万晓春研究员毕业于加拿大蒙特利尔大学医学院，在世界首次成功研制抗EPHRIN家族成员的单抗和多抗试剂，引起多家公司的关注，并在类风湿关节炎、肝炎等多种疾病模型试验中有重大发现，获得加拿大国家健康研究院（CIHR）优秀研究员奖

2、。万晓春研究员具有多年在GLP实验室条件下临床及临床前的研究经历，具有在CRO GLP实验室进行抗体和临床样品分析，免疫学方法研发和验证的经验，对抗体药物的PD/ PK药物检测和临床药物分析具有丰富的经验。万晓春研究员近些年来分别在宾夕法尼亚大学、Eisai、Merck及 Frontagelab等美国一流的科研与大型制药公司以高级研究员从事单抗药物的研发工作，曾与美国大型生物制药公司 HUMAN GENOME SCIENCE公司合作研究DcR3基因在免疫系统中的作用，首次在世界上成功研制DcR3 的广谱癌症检测系统（ELISA 试剂盒），在癌症检测及监测上有重大意义。主要科研成果及所获荣誉1.

3、 Wan X, Shi G, Semenuk M, Zhang J, and Wu J. DcR3/TR6 modulates immune cell interactions. J Cell Biochem. 2003 Jun 1; 89(3): 603-122. Wan X*, Zhang J*, Luo H, Shi G, Kapnik E, Kim S, Kanakaraj P and Wu J. A TNF family member LIGHT transduces costimulatory signals into human T cells. J Immunol. 2002

4、Dec 15;169 (12):6813-21(*equal contribution)3. Shi G, H Luo, Wan X, J Zhang and Wu J. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 2002 Nov 1;100 (9):3279-864. Wan X*, Zhang J*, Salcedo TW*, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore

5、 PA, and Wu J. Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin. Invest. 2001 Jun;107(11):1459-68 (*equal contributors)5. Luo H, Wan X, Wu Y, and Wu J. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J Immunol 2001 Aug 1;167(3):1362-706. Luo H

6、, Wu Y, Qi S, Wan X, Chen H, and Wu J. A proteasome inhibitor effectively prevents mouse heart allograft rejection. Transplantation 2001 Jul 27;72(2):196-2027. Chen H, Xu D, Luo H, Loubeau M, Wan X, Peng J, Qi S, Daloze P, Fritzsimmons W E, Bersky I, Peets J, Sehgal S N, and Wu J. Compromised renal

7、graft rejection response in Vervet monkeys after withdrawal of immunosuppressants Prograf and Sirolimus. Transplantation 69:1555-1561, 2000其他2004-2007 加拿大健康研究院优秀研究员奖2005 临床免疫学会联合会会议摘要和旅行奖联系方式邮箱xc.wan电人主页备注NameXiaochun WanPositionsexecutive director of the centreAcademic titleprofessorE-

8、mailxc.wanPhonersonal WebsiteResume Dr. Wan was graduated from the medical school of University of Montreal. He is the first scientist in the world who was succeeded in developing the anti-EPHRIN monoclonal antibodies and polyclonal antibodies. He also made some important discoveries in

9、 a variety of disease models such as rheumatoid arthritis and hepatitis and won the scholar award of Canadian Institute of Health Research (CIHR). He has many years of experience on the research and development of therapeutic antibody drugs and investigation of autoimmune diseases. Dr Wan has more t

10、han six years of GLP research experience in clinical and preclinical laboratories and experience of antibody and clinical samples analysis in CRO GLP laboratory. He is also an expert on PD/PK antibody drugs and clinical drug analysis. Dr Wan had been working in the University of Pennsylvania, severa

11、l well-known pharmaceutical companies such as Eisai, Merck, Frontagelab in the past years. He had been working with HUMAN GENOME SCIENCE biopharmaceutical corporation in studying the role of DcR3 in immune system. He was the first investigator in developing a DcR3 ELISA kit (a broad spectrum of canc

12、er detection system) that has great significance in cancer detection and surveillance.DirectionTherapeutic antibody developmentimmune cell signalingAutoimmune/inflammation and cancer therapyAchievements2004-2007 Canadian Institute of Health Research (CIHR) Scholar Award2005Abstract and travel award,

13、 Federation of clinical immunologist Societies (FOCIS) ConferenceArticle1. Wan X, Shi G, Semenuk M, Zhang J, and Wu J. DcR3/TR6 modulates immune cell interactions. J Cell Biochem. 2003 Jun 1; 89(3): 603-122. Wan X*, Zhang J*, Luo H, Shi G, Kapnik E, Kim S, Kanakaraj P and Wu J. A TNF family member L

14、IGHT transduces costimulatory signals into human T cells. J Immunol. 2002 Dec 15;169 (12):6813-21(*equal contribution)3. Shi G, H Luo, Wan X, J Zhang and Wu J. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 2002 Nov 1;100 (9):3279-864. Wan X*, Zhang J*, Salcedo T

15、W*, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, and Wu J. Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin. Invest. 2001 Jun;107(11):1459-68 (*equal contributors)5. Luo H, Wan X, Wu Y, and Wu J. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J Immunol 2001 Aug 1;167(3):1362-706. Luo H, Wu Y, Qi S, Wan X, Chen H, and Wu J. A proteasome inhibitor effectively prevents mouse heart allograft rejection. Transplantation 2001 Jul 27;72(2):196-2027. Chen H, Xu D, Luo H, Loubeau