MASCISImpactorNYU脊髓损伤模型打击器

1、MASCIS Impactor, NYU Impactor)脊髓损伤模型打击器是设计用来为大小鼠施加可重复的标准脊椎撞击。已经开发应用超过十年，它是啮齿类动物脊髓损伤模型的一部分，已经有超过100 个实验室在使用它。另外，最近超过50%的关于脊髓损伤研究文献使用的是MASCIS撞击 器 。 大 部 分 仪 器 的 建 议 操 作 程 序 是 源 自 于MulticenterAnimalSpinal CordInjuryStudy(MASCIS)模型和实际工作经验。现有 MASCIS撞击器现在是它的第三代产品，与以前的产品相比已经有很多方面的改进提高。现有两个型号的撞击器。电脑版撞击器可以记录数

2、据。同时也可以使用基本版撞击器(The Rutgers Impactor) 仅进行撞击，不记录数据。电脑版撞击器可以精确测量一个10 克的小棒的运动情况， 这个小棒从12.5mm ，25mm ，50mm高处落到术后暴露的脊髓T9-10 处。另外设备还可以测量撞击位置脊柱的运动。显示坠落小棒的轨迹，并测量撞击速度（ImpV ），脊髓压缩距离（Cd），脊髓压缩时间(Ct)，脊髓压缩率(Cr)。这些撞击参数本身是相关的，同时与其它的脊髓损伤数值如组织Na，K 浓度，运动恢复 locomotor recovery(BBB 评分 )也是相关的 . MICFORCE米力光国际 CO.LTDThe MASC

3、IS Impactor is a device designed to deliver graded reproducible spinal cord contusions in rats. Developed over ten years ago, the Impactor is part of a well-defined rodent spinal cord injury model that is used in over 100 laboratories around the world. In addition, more than 50% of recent publicatio

4、ns on spinal cord injury research used the MASCIS Impactor. Most of the recommended procedures for the Impactor are based on experience with the model and work done by the Multicenter Animal Spinal Cord Injury Study (MASCIS).The Impactor is now in its third generation with many improvements over pre

5、vious models. It is available in a model with data recording capability (description and picture links) which requires a Pentium computer. It is also available in a basic model (The Rutgers Impactor) which only does the impact, not the recording of data.Clamping systems are available for both rat an

6、d mouse.A clamping system is necessary for theRutgers basic model and serves as a functional enhancement for the MASCISmodel. (description and picture .) When using a clamping system with the MASCIS model, a CS-tie device also is needed.The MASCIS Impactor, formerly called the NYU Impactor, was deve

7、loped in 1991 by Drs. John Gruner, Carl Mason, and Wise Young. It is now used in laboratories throughout the world in their spinal cord injury studies. The device precisely measures the movement of a 10-gram rod dropped 12.5, 25.0, or 50.0 mm onto the T9-10 spinal cord exposed by laminectomy. In add

8、ition, the device measures movement of the spinal column at the impact site, displays the trajectory of the falling rod, and measures the impact velocity (ImpV), cord compression distance (Cd), cord compression time (Ct), and cord compression rate (Cr). These impact parameters correlate with each ot

9、her and spinal cord lesion volumes (estimated from tissue Na and K concentrations) and locomotor recovery (BBB scores).1: Serial changes in bladder, locomotion, and levels of neurotrophic factors in rats with spinal cord contusion.Hyun JK, Lee YI, Son YJ, Park JS.Department of Rehabilitation Medicin

10、e, Dankook University, Cheonan, Korea.rhhyundankook.ac.kr2: A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model. Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.Brain Res. 2008 Dec 3;1243:146-51. Epub 2008 Sep 24.3 :The role

11、of cation-dependent chloride transporters in neuropathic pain following spinal cord injury. Cramer SW, Baggott C, Cain J, Tilghman J, Allcock B, Miranpuri G, Rajpal S, Sun D, Resnick D. Mol Pain. 2008 Sep 17;4:36.4: Novel combination strategies to repair the injured mammalian spinal cord. Bunge MB.J

12、 Spinal Cord Med. 2008;31(3):262-9. Review.5: A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury.Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD. Exp Neurol. 2008 Sep;213(1):129-36. Epub 2008 Jul 14.6: B1 and TRPV-

13、1 receptor genes and their relationship to hyperalgesia following spinal cord injury.DomBourian MG, Turner NA, Gerovac TA, Vemuganti R, Miranpuri GS, TV, Resnick DK.Spine. 2006 Nov 15;31(24):2778-82.reyenü K, Satriotomo I, Miletic7:Endothelial cell loss is not a major cause of neuronal and glia

14、l cell death following contusion injury ofthespinal cord.Casella GT, Bunge MB, Wood PM.Exp Neurol. 2006 Nov;202(1):8-20. Epub 2006 Jul 26.8:Recoveryof functionfollowinggraftingof humanbone marrow-derivedstromalcells into the injuredspinal cord.HimesBT, NeuhuberB, ColemanC, KushnerR, SwangerSA, Kopen

15、GC, WagnerJ, ShumskyJS,Fischer I.9: Mechanical and cold allodynia in a rat spinal cord contusion model. Yoon YW, Dong H, Arends JJ, Jacquin MF.Somatosens Mot Res. 2004 Mar;21(1):25-31.10: Spinal cord contusion models.Young W.Prog Brain Res. 2002;137:231-55. Review.出师表两汉：诸葛亮先帝创业未半而中道崩殂， 今天下三分， 益州疲弊，

16、此诚危急存亡之秋也。然侍卫之臣不懈于内，忠志之士忘身于外者，盖追先帝之殊遇，欲报之于陛下也。诚宜开张圣听，以光先帝遗德，恢弘志士之气，不宜妄自菲薄，引喻失义，以塞忠谏之路也。宫中府中，俱为一体；陟罚臧否，不宜异同。若有作奸犯科及为忠善者，宜付有司论其刑赏，以昭陛下平明之理；不宜偏私，使内外异法也。侍中、侍郎郭攸之、费祎、董允等，此皆良实，志虑忠纯，是以先帝简拔以遗陛下：愚以为宫中之事，事无大小，悉以咨之，然后施行，必能裨补阙漏，有所广益。将军向宠，性行淑均，晓畅军事，试用于昔日，先帝称之曰愚以为营中之事，悉以咨之，必能使行阵和睦，优劣得所。“能 ”，是以众议举宠为督：亲贤臣，远小人，此先汉所以兴隆也； 亲小人， 远贤臣，此后汉所以倾颓也。 先帝在时，每与臣论此事， 未尝不叹息痛恨于桓、 灵也。侍中、尚书、长史、参军，此悉贞良死节之臣，愿陛下亲之、信之，则汉室之隆，可计日而待也。臣本布衣，躬耕于南阳，苟全性命于乱世，不求闻达于诸侯。先帝不以臣卑鄙，猥自枉屈，三顾臣于草庐之中，咨臣以当世之事，由是感激，遂许先帝以驱驰。后值