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1、Business Plan ofMedical Biological Engineeringof Stem Cellsby SinoCells BioTechnologies Co., Ltd.About SinoCellsSinoCells BioTechnologies Co., Ltd. is a high-tech corporation that is engaged in researches and applications of stem cells. Our scientists and founders had presided over some world famous

2、 institutes, and began to arrange this company from October 2000.Founder & Stock ProportionBeijing B & M Gene Technology Investment Co., Ltd. 65%Scientists Team 25%Peking University Liver Diseases Institute 5%Beijing COTEC New Technology Co. 5%Business TenetResearch is for application, whereas appli

3、cation is from research.BackgroundScience Magazine: the top-ten scientific breakthroughs of 1999:1. It was found by American Scientists that stem cells derived from human embryos or bone marrows can be cultivated into various cells, tissues, and organs of human body. Thus, it is hoped that the stem

4、cells will become new source of transplanted organs in future. 2. Scientists have successfully completed the analysis of gene sequence of three microbes, as well as one third of human genome sequence, including completely translating the genetic code of 22nd pair human chromosome. 3. Scientists cool

5、 fermi to approximately absolute zero so as to evoke the wave-like nature of atoms but not characteristics of single particle.4. Scientists drew the first image of ribosome configuration. 5. Astronomer found some new planets exterior to solar system. This discovery made the sum of extra-solar-system

6、 planets add up to about 30. Besides, a scientist declared that he had detected the light of a star reflected by certain extra-solar-system planet for the first time. 6. Scientists found new molecules in the brain, concerning with memory and learning capacities. 7. Astronomer obtained some new evide

7、nce that prove the universe is flat, and they established a precise system of balance between substances and energies, which provide new proof for the theory that a tremendous explosion give birth to the universe. 8. American and English scientists invented certain optical crystals, which can operat

8、e light wave like semiconductors operate electric current. 9. Archaeologists found the oldest cell fossils of today in Australia. This discovery shifted the know age of the earliest life to 2.7 billion years ago, which is 1.0 billion earlier than what people thought before. 10. Scientists discovered

9、 there is some relationship existing between the explosion of gama-ray and the emergence of black hole. Science Magazine: the top-ten scientific breakthroughs of 2000:1. Scientists from six nations (including America and England) cooperated to achieve the task of drawing a draft of human genome. Mor

10、eover, they determined the base sequence of human genome on the whole. 2. This year, studies about RNA gave some supports to the hypothesis that life of the world may come from RNA. 3. Georgias scientist excavated cranial bones of some primitives that lived 1.70 million years ago. These cranial bone

11、s probably belonged to the first group of human ancestors coming from Africa. 4. Advancement of plastic electronics. This year, conductive plastics appeared to be the foundation of most technical achievement utilizing polar molecules. And the three scientists who discovered this material were awarde

12、d the Nobel Prize of Chemistry.5. Advancement of studies about clone and stem cells. Scientists successfully achieved the cloning of the most difficult animals, pigs and white-extreme wild ox. This achievement is of great importance to save some almost extinct animals. 6. Studies indicated that ther

13、e might be some water flowing on the surface of the mars. Moreover, it was inferred from some photos of th3e mars that lakes and rivers used to widely spread on the red planet. 7. Scientists from various nations that participated in the observing and measuring project about extra-galaxy radiation of

14、 millimeter waves and physical balloon of the earth proved that the universe is flat through observation and study.8. The new discoveries of scientists about the multiple functions of hormone receptors enhanced peoples understanding about cholesterol metabolism, production of fatty acids, and the pa

15、thogenesis of diabetes and cancers. 9. On Feb. 14th, , an American space detector named dating of little planets close to the earth entered the orbit of little planet cupid.10. Quantum physics has got great discoveries. Researchers found electric current can simultaneously move in two different dire

16、ctions surrounding a super-conductive wire loop. Scientists also presented an idea about the characteristic of quantum that the so-called tangling characteristic could be spared at the moment that a quantum computer is on operating. Revolutions of Biology and MedicineInnovation of the application of

17、 stem-cell studies* Bill Gates predicted that the next richest tycoon being of the world must come from the field of biological technique. * In April 2000, 73 world-known scientists, including 61 Nobel Winners, acquired the Congress to abolish the forbidden ordination on embryo stem-cell researches

18、together, and expressed great supply for stem-cell studies. * On Feb 22nd 2001, 80 American Nobel Winners urged President Bush to provide financial supplies for the research of stem cells obtained from human embryos. Swift response of American government* On August 4th 2000, the United States permit

19、s government-assisted researches about stem-cell obtained from human embryos. American President Clinton announced. * Clinton required the public to think over some incredible potential benefits might be brought out by stem-cell researches, and he pointed out that some strict scientific criteria is

20、included in this directive guidance. * It was National Institute of Health who said that stem-cell research would probably bring us some methods to treat, if not cure, some severe diseases and traumas, including Parkinson Disease, Diabetes, Heart diseases, various sclaredema, burn injury, and Spinal

21、 cord injury. * On August 23rd, Congress of the United States passed some permitting proposal concerning with embryo stem-cell researches.Technique StatusCore TecnniquesSinoCells have already grasped some top-ranking techniques in the world, including partitioning technique of stem cells, differenti

22、ating and proliferating techniques of stem cell, clinical application of techniques concerning with stem cells, gene chips used for stem cells differentiation and induction, type-matching stem cell bank, and biological network of stem cells. Allying with Peking University Health Science Center, Sino

23、Cells has established Peking University Stem Cell Research Center, which reaches the most advanced level in the world. Construction and fitment of this center has been completed now, and the major instruments have already arrived. Strategy RelationshipSinoCells and experimental center has establishe

24、d strategy alliance with some correlative research organizations in U.S.A. (Harvard University, Washington University, Stanford University) and Stowers Medical Institute. We sent some stem-cell products to correlative American laboratories for further studies. And the results appear to be quite exci

25、ting. Being selected us as the first few enterprises entering into the Zhongguancun Life Science Park by Beijing Municipal GovernmentHave established researching and clinical cooperation with more than the 10 largest hospitals in BeijingProjects have been included into the major supporting projects

26、of The Biologic Techniques and New Drugs of Beijing Municipal Committee for Science and Technology. Marketing and IndustrializationWhat is stem cell?Stem cell is the original cells. According to the function, stem cells can be divided into totipotential stem cell and tissue-specific stem cells. The

27、former can grow and differentiate to form a whole body, and the latter is original cells of one or several types of tissues. Embryo stem cells of human being will grow into human body at last, so these cells are totipotential stem cells and clone-human or clone-animals should begin with such cells.

28、Stem cells are the fundamental materials of growth and development of the entity of human body.Totipotential stem cellMultipotential stem cellSingle-potential stem cellMechanism of stem-cell techniqueWe would like to say that the renovation and survival of life entity is embodied by the proliferatio

29、n of stem cells.Cells or tissues that are unable to differentiate into new cells must depend on stem cells to reproduce themselves and maintain the sum of cells in the body.With the rapid development various biotechnology (such as gene engineering, embryo engineering, and cell engineering) intention

30、ally in vitro artificial partitioning and stem cell cultivation become possible now. The cells, tissues, and organs that are modeled from stem cells became the source of transplanted organs. And this advance will be the main direction of stem-cell application in medical biological engineering. The m

31、ajor stem-cell techniques that SinoCells has grasped* Partitioning technique of stem cell* Purifying technique of stem cell* In vitro cultivating technique of stem cell* Clinical application of stem-cell technique* Gene chip was utilized in the studies about stem cell differentiation and inductionTh

32、e major stem-cell techniques that SinoCells has grasped* Partitioning, purification and cultivation of embryo stem cells* Looking for specific stem cells of certain tissues* Partitioning, purification, and non-differentiating proliferation of specific stem cells * Transverse differentiation of speci

33、fic stem cells* Screening and reforming traditional drugs by means of stem-cell techniqueThe prospect and advantages of application of stem-cell technique1. Broad therapeutic scope:A. Endocrine disturbance: diabetes, etc. B. Cellular injury diseases: liver diseases, etc.C. Organ damaging diseases: k

34、eratopathies, etc.D. Degenerative Diseases: Parkinson Disease, ect.E. Cancers: leukemia, etc.2. Absolutely non-toxic, refrained from exclusion.3. Extremely effective: transient intervention, permanent therapy4. No need to be profoundly acquaint with the pathogenesis 5. Abundant source of therapeutic

35、 materialsClinical application of embryo multipotential stem cells * Liver diseases: liver regeneration* Hematopathies: replacing bone marrow source* Diabetes: rebuilt islet cells.* Keratopathies: cultivate and transplant new crneaStatus of the market of liver diseasesThere are 120 million HBV and 1

36、5,000 thousand HCV carriers in China.The incidence rate of HBV carriers is 20%, a population of approximately 24,000 thousand people; the incidence rate of HCV carriers is 50%, about 7,500 thousand; some of them transform into liver cirrhosis or liver carcinoma. Total capacity of the market: 31,500

37、thousand people. If each patient pays 6000 yuan annually as medical consumption, the sum will be 18,900 million yuan per year.Global market capacity of diabetes drugsNowadays, diabetes has already become the third chronic non-infective diseases most harmful to human health after cardiac & cerebral v

38、ascular diseases and tumors. According to the proclamation of World Health Organization, there were 30,000 thousand diabetic patients in the world in 1985. In 1995, the number of the patients rose to 135 million. And up to 2025, this population will be more than 300 million. According to the proclam

39、ation, the increasing trend of diabetes will result in the enhancement of national and family medical consumptions. For example, therapeutic payment of a diabetic patient in India has already taken 25% of the income of his family. While in U.S.A., the average consumption of a diabetic patient is als

40、o more than 10 thousand USD. (Data source: Diabetes Prevention Office of China)Chinese market of diabetic drugsAccording to an investigation concerning with 11 Chinese provinces that involved 40 thousand urban and country residents, the incidence rate of diabetes has risen from 0.6-0.7% to todays 3.

41、21%, an enhancement of almost 5 time.According to the remarks of Professor Li Tian of China preventive medical academy, there are more than 20,000 thousand diabetic patients older than 20 year-old, and 30,000 persons are diagnosed as Impaired Glucose Tolerance (Pre-symptoms of diabetes indicating im

42、paired pancreatic function).There are 58,000 thousand diabetic patients in China, including as many as 2,000 thousand type-1 diabetic patients. During the years between 1997 and 1999, total therapeutic consumption of diabetic patients allover the country was as high as RMB 170,000 million yuan. (Dat

43、a source: Diabetes Prevention Office of China)Developing project of industrialization1. Establish tissue-specific adult stem cell bank (type-matching stem cell bank: 500040000 types)2. Establish in vitro stem-cell amplifying system (America and China)3. Establish in vitro orientated inductive system

44、 (patent of gene chip)4. Establish basic principles and operating standard of stem-cell clinical treatment5. Establish Chinese stem-cell treatment center hospital and training center for clinicians6. Establish 50-500 combined and cooperated treatment center 7. Establish stem-cell drug-screening cent

45、er; reform 5-10 traditional drugs so as to cooperate with correlative pharmaceutical factories8. Support long-range medicine and management by means network technique9. Promote innovations of stem-cell treatment on the basis of various public relations10. Cultivate a brand of corporation and make it

46、 famous in the worldIncome Model & Corporation EvaluationSource of income1. Treatment income 2. Drug profit3. Technique license4. Training income5. Value increment of assigned biological consuming materials.6. Profit of network service7. Income from sale and rent of integrated instruments8. Income f

47、rom comprehensive service of hospitalsMarket target of the first group of projectsAccording to the industrialized extent of stem-cell study achievement in each kind of disease, it is predict that there will be more than ten billion of business income in the coming 5-10 years. * Keratopathies: market

48、 target is 500 thousand per person (market proportion is about 10%). Calculated as 10 thousand yuan per patient, the business income will be 5,000 million yuan.* Diabetes: market target is 300 thousand per person (market proportion is about 10%). Calculated as 15 thousand yuan per patient, the busin

49、ess income will be 4,500 million yuan.* Liver diseases: market target is 2,200 thousand per person (market proportion is about 5%). Calculated as 15 thousand yuan per patient, the business income will be 33,000 million yuan.* Hemetologic diseases: market target is 50 thousand per person (market prop

50、ortion is about 5%). Calculated as 50 thousand yuan per patient, the business income will be 2,500 million yuan.* Establish clinical application and training system after the achievements have been verified by clinical trials. Then the achievements will enter into various large hospitals and even ex

51、tend to foreign nations (foreign market should be calculated apart) by means of joint cooperation, linkage, alliance, and technology transfer and cooperation. * Prediction of the income obtained from treatment of diabetes and liver diseases(40% was deducted from the total income as shared-profit of

52、cooperation and expenditure of taxes)Value of our corporationEvaluation of SinoCellsUSD 123 million Diabetes22 Liver diseases23 Keratopathy 20 Hematologic 16 Senile dementia & Parkinson Syndrome 14 Flat for screening of drugs 18 Others 10Scientists of Corporation & Manager TeamRisk, Competition and

53、AdvantageTechnical RiskIt will take about half a year to study and achieve the partitioning and purifying techniques of specialized stem cells of various tissues.It will take one year or so to find the proper orientated induction-condition for the transverse differentiation of stem cells.Risk of Man

54、agementAs different patients may response differently to the therapy of stem cells, which will result in different outcomes, we must strictly select the patients by corresponding index. As individual difference will also influence the effects of treatment, we must assign specific therapeutic schedul

55、e for each patient. Personnel-depended risksLoss of high-tech personnel must be disturbing to normal operation of the center. Therefore we must guarantee their payment and profits so as to connect them with the corporations profits.SinoCells will give some major technical personnel certain stocks or

56、 shares. The researches of our competitors are concentrating on blood stem-cell techniques. * Shanghai No.2 People Hospital has different technical system from us. We two can supplement each other. Moreover, the nuclear-changing technique and IVF technique are similar, so they are easy to grasp. * Tianjin Blood Institute attempted to establish a mesenchymal stem cell bank.Our characteristics Three domains:1. Established stem cell bank (for vari