非酒精性脂肪性肝炎论文：非酒精性脂肪性肝炎苦乐清汤临床研究

1、床研究【中文摘要】非酒精性脂肪性肝炎(NASH),是西方国家最常见的肝脏疾病之一，随着国人生活水平的提高，糖尿病、高脂血症、高血压、冠心病等“富贵病”的发病率不断上升，NASH成为肝源性转氨酶升高的主要原因之一。也是隐源性肝硬化的重要病因之一，目前尚缺乏理想的治疗药物。苦乐清汤是我们根据国医大师一周仲瑛教授多年临证经验,从“肝肾不足，痰瘀湿阻”基本理论出发，综合国内外多家研究成果,提炼整理出来的治疗NASH方药。经临床初步观察发现该方具有保肝降酶、调节血脂和血糖、降低肝内脂肪含量，逆转肝纤维化及早期肝硬化等多重作用。研究通过临床试验，进一步观察苦乐清汤治疗NASH的临床疗效，评价其治疗NASH

2、I临床疗效，观察其安全性，为临床治疗NASH提供有效药物。方法：选择40例符合入选病例标准的患者，随机分为治疗组和对照组，治疗组予苦乐清汤，对照组予易善复(多烯磷脂酰胆碱)。3个月为1疗程，观察ALTASTGGTAKP等肝脏酶学指标、肝脏脂肪浸润程度及相关安全性指标，采用SPSS10.0进行统计学处理分析，客观评价苦乐清汤的安全性及有效性。结果：苦乐清汤具有明显的改善NASH患者乏力、消化不良、肝区隐痛等临床症状及体征作用，对ALTASTGGTAKP等肝脏酶学指标改善作用显著，可降低肝脏脂肪浸润的程度及体重指数，对血常规、尿常规、肾功能等安全性指标无显著性影响。结论：苦乐清汤确是有效治疗NAS

3、H的方药,值得进一步深入研究。【英文摘要】Background:Non-alcoholicsteatohepatitis(NASH)isoneofthemostcommonlyseenhepatopathyinwesterncountries.WhileinChina,withtheimprovementoflivingstandardandtheincreasinginmorbidityoftherichpeople'sdiseaseslikediabetes、hyperlipidemia、hypertension、coronaryheartdisease,NASHsbecoming

4、oneoftheprimarycausestotheriseofhepatogenicaminotransferaselackingofcertaineffectivemedicinecurrentlyandtocryptogeniccirrhosis.Kuleqing,basedupontheexperieneeofprofessorZhouZhongyingafamousexpertdevotinghiswholelifetoChinesemedicine,proceedingfromthebasicpathogenesisofdeficiencyofliverandkidneyaswel

5、lasphlegmaccumulatingwithstagnation',combiningthedomesticandoverseasresearchachievements,isexpectedtobeaneffectivepatentherbalmedicineforNASH.Afterthepreliminaryobservation,wefinditsmultiplerolesinprotectingliver-cellandreducingaminotransferase、adjustingthelipidemiaandbloodglucose、loweringdownth

6、elipidcontentintheliver、reversingliverfibrosisandearlycirrhosis.:tofurthertestandverifytheclinicaleffectofKuleqingonNASHandtoobserveitssafety,andallinall,toprovideaneffectivemedicineforthetreatmentofNASH.Method:weselect40qualifiedcasesanddivideintotreatmentgroup(withKuleqing)andcontrolgroup(withEsse

7、ntiale)randomly.weset3monthsasatherapeuticcourseandmonitorthebiologicalindicatorasALTASTTBIL、GGTAKPandalsotheinfiltratingdegreeoflipidintheliveraswellasrelevantsafetyindicator.Then,wedothestatisticanalysisbySPSS10.0andobjectivelyevaluateitsefficiencyandsafety.Result:Kuleqingcannotonlyimprovetheclini

8、calmanifestationsandsignslikefatigue、indigestion、dullpainintheliverarea、hepatosplenomegalybutalsothebiologicalindicatormarkedly、lowerdowntheleveloflipidinfiltrationandBMI.wehaven'tfoundanyadverseeffectfromthebloodroutinetest、urineroutinetestandrenalfunction.Conclusion:itistrueaeffectivemedicineforNASHanddeservefurtherresearches.【关键词】非酒精性脂肪性肝炎苦乐清汤临床研究【英文关键词】Non-alcoholicsteatohepatitisKuleqingtangClinicalresearch【目录】苦乐清汤治疗非酒