Scalablearchitectureinmammalianbrains在哺乳动物的大脑可扩展的体系结构学习教案

1、会计学1Scalablearchitectureinmammalianbrains在哺乳动物的大脑在哺乳动物的大脑(dno)可扩展的体可扩展的体系结构系结构第一页，共42页。第1页/共41页第二页，共42页。Abbott and Nelson,Nat. Neurosci.第2页/共41页第三页，共42页。第3页/共41页第四页，共42页。CA3-CA1 synapse of hippocampusRich history of extracellular and single-cell recordingThe cell biology and plasticity literature is

2、 vastOne synapse per connectionHas AMPA, NMDA, mGluR,第4页/共41页第五页，共42页。第5页/共41页第六页，共42页。第6页/共41页第七页，共42页。Nishiyama et al. 2000 Nature 408:58480 pairings at 5 Hz Cesium pipet solutionPike et al. 1999Journal of Physiology 518:57140 pairings at 5 Hz Four epochs (10 pairings each) at 10-s intervalsChrist

3、ie et al. 1996Learning and Memory 3:160900 pairings at 3 HzEpochs (30-60 pairings each) at 5-s intervalsAt the CA3-CA1 synapse, pairing single APs givesLTP.no change.LTD.第7页/共41页第八页，共42页。Single pre+post APs100 pairings with Dt=0-7 ms (pre before post)Pairing frequency 0.1-5 Hz第8页/共41页第九页，共42页。In Nis

4、hiyama et al. Cesium replaced Potassiumin the intracellular pipette solutionThis will-depolarize neuron -block A-type K channels in dendrite-broaden action potentials第9页/共41页第十页，共42页。PotassiumCesiumCs+K+pairings given at 5 Hz第10页/共41页第十一页，共42页。Cs+K+can bursts of APs emulate Cs+?第11页/共41页第十二页，共42页。LT

5、P induction requires postsynaptic bursting第12页/共41页第十三页，共42页。CA1 neurons fire bursts during theta oscillation第13页/共41页第十四页，共42页。Pairings must be given at high frequencyDt第14页/共41页第十五页，共42页。第15页/共41页第十六页，共42页。All pairings given at 5 Hz第16页/共41页第十七页，共42页。第17页/共41页第十八页，共42页。RequirementThetaBurstingLTP

6、yes yesLTD no no第18页/共41页第十九页，共42页。第19页/共41页第二十页，共42页。Why not explore parameter space exhaustively?because its exhausting!第20页/共41页第二十一页，共42页。Shy ShohamUncaging in spatial patterns: High-throughput screening of neural responsesResolution: 1 Hz10 Hz10 Hz第36页/共41页第三十七页，共42页。butdissectable?Complex第37页/共41页第三十八页，共42页。第38页/共41页第三十九页，共42页。第39页/共41页第四十页，共42页。第40页/共41页第四十一页，共42页。NoImage内容(nirng)总结会计学。Abbott and Nelson,。Nat. Neurosci.。at 5-s intervals。-broaden action