Chapter14Tcellmediatedimmuneresponse学习教案

1、会计学1Chapter14TcellmediatedimmuneresponsecellsChapter 14 Chapter 14 T Cell Mediated Immune ResponseT Cell Mediated Immune Response（CMICMI）第1页/共97页第2页/共97页第3页/共97页第4页/共97页第5页/共97页第6页/共97页Lymph node, Spleen, MALT第7页/共97页被膜被膜输出淋巴管输出淋巴管Capture and presentation of exogenous Ags tissueLymphatic vesselDC an

2、tigenAfferentLymphatic vessel cortexLymph node 第8页/共97页第9页/共97页 CD4+T cell mediated immune response CD8+T cell mediated immune response第10页/共97页Cell surfacepeptidesof AgAntigens must be processed in orderto be recognised by T cellsYT T cellresponseNo T cellresponseNo T cellresponseNo T cellresponseN

3、o T cellresponseSolublenative AgCell surfacenative AgSoluble peptidesof AgCell surface peptides of Ag presented by cells that express MHC molecules第11页/共97页第12页/共97页第13页/共97页第14页/共97页第15页/共97页Three dimensional structure of TCR第16页/共97页Anatomical mechanism of TCR recognizes MHC/antigenic peptideMHC-a

4、 a helixAntigenic peptideCDR1CDR2CDR3CDR3CDR2CDR1TCR-b b chainTCR-a a chainMHC-a a helix第17页/共97页CDR3CDR2,1CDR1,2第18页/共97页第19页/共97页第20页/共97页第21页/共97页第22页/共97页第23页/共97页TCR complex第24页/共97页第25页/共97页The Two-Signal HypothesisCo-stimulatory signal(CD28/B7)第26页/共97页第27页/共97页第28页/共97页CD4MHC-IITCR/CD31ICAM-

5、1B7-1B7-2LFA-1LFA-1ICAM-3LFA-3B7-1CD28CD28LFA-1ICAM-3CD22Molecules associated with T activation Th cellAPCCTLA-4第29页/共97页第30页/共97页APCblock Tblock Th activityactivityDual signal model of Th cell activationIL-2RAPCThSignal 1Signal 2LPSTNF-a IL-1 IL-6IL-2ThSignal 1Th activatedactivatedCD28CD28B7第31页/共9

6、7页第32页/共97页第33页/共97页第34页/共97页第35页/共97页第36页/共97页TmEffector TProliferation of T cell第37页/共97页IL-12 IL- 4AgIL-23（IL-6，TGF-）Th17（IL-17）第38页/共97页n characteristic of memory T Cells (Tm): Long lived cells CD45RA-,CD45RO+ Easily triggered by low antigen Less dependent on co-stimulatory molecules Sensitive t

7、o CKs Responsible for maintaining immunological memory第39页/共97页第40页/共97页Days after immunityRatio of specific T cells in blood感应阶段Primary immunitySecondary immunity1/100001/10001/1000 7 14 21 28 35 42 Principle of T cell mediated immune responsecell mediated immune response Immunological memory第41页/共

8、97页第42页/共97页第43页/共97页第44页/共97页第45页/共97页（Th1，Tc）第46页/共97页第47页/共97页第48页/共97页第49页/共97页第50页/共97页第51页/共97页第52页/共97页第53页/共97页第54页/共97页Th1 cells. 第55页/共97页第56页/共97页第57页/共97页第58页/共97页nMHC restriction第59页/共97页第60页/共97页b b2mTCR-b b chainTCR-a a chain Homocysteine HLA-A68PeptideInteraction between TCR and homo

9、cysteine presented by HLA-A68 C第61页/共97页第62页/共97页第63页/共97页APC第64页/共97页Dual signal model of Tc activationTumor cellDCCD28CD28B7B7CD28第65页/共97页第66页/共97页第67页/共97页第68页/共97页第69页/共97页第70页/共97页第71页/共97页第72页/共97页第73页/共97页第74页/共97页第75页/共97页Normal cell No injury No injury第76页/共97页*Fas：Apo-1 or CD95第77页/共97页第78页/共97页 第79页/共97页CTL cellTarget cell第80页/共97页第81页/共97页第82页/共97页第83页/共97页第84页/共97页第85页/共97页第86页/共97页第87页/共97页第88页/共97页第89页/共97页NKTcells第90页/共97页第91页/共97页第92页/共97页第93页/共97页Superantige