动脉自旋标记灌注功能磁共振成像

1、动脉自旋标记灌注功能磁共振成像Arterial Spin Labeling Perfusion fMRIArterial Spin Labeling Perfusion fMRIHistoryAlsop, D. C., and Detre, J. A. 1998. Multisection cerebral blood flow MR imaging with continuous arterial spin labeling. RadiologyDetre, J. A., and Alsop, D. C. 1999. Perfusion fMRI with arterial spin lab

2、eling. Functional MRIHistoryJiongjiong Wang, Ph.D. Research Assistant Professor of Radiology and NeurologyUniversity of PennsylvaniaHistory1. J. Wang, D.J. Licht (2006) Pediatric perfusion MRI with arterial spin labeling Neuroimaging Clinics of North America 16: 149-1672. J. Wang, H. Rao, G.S. Wetmo

3、re, P.M. Furlan, M. Korczykowski, D.F. Dinges, J.A. Detre (2005) Perfusion fMRI reveals cerebral blood flow pattern under psychological stress. Proceedings of the National Academy of Sciences of U.S.A. 102:17804-17809.3. J.Wang, Z. Wang, G.K. Aguirre, J.A. Detre (2005) To smooth or not to smooth? ?

4、ROC analysis of perfusion fMRI data. Magn. Reson. Imag. 23: 75-814. J. Wang, Y. Zhang, R.L. Wolf, A.C. Roc, D.C. Alsop and J.A. Detre (2005) Amplitude modulated continuous arterial spin labeling perfusion MRI with single coil at 3.0 Tesla. Radiology 235:218-2285. J. Wang, D.J. Licht, G.H. Jahng, C.S

5、. Liu, J.T. Rabin, J. Haselgrove, R.A. Zimmerman and J.A. Detre (2003) Pediatric perfusion imaging using pulsed arterial spin labeling. J. Magn. Reson. Img. 18(4):404-413.6. J. Wang, G.K. Aguirre, D.Y. Kimberg, J.A. Detre (2003) Empirical analyses of null-hypothesis perfusion fMRI data at 1.5 and 4.

6、0 Tesla. Neuroimage. 19(4):1449-1462.7. J. Wang, D.C. Alsop, H.K. Song, J.A. Maldijian, K. Tang, A.E. Salvucci, J.A. Detre. (2003) Transit time imaging with flow encoding arterial spin tagging (FEAST). Magn. Reson. Med. 50(3):599-607.8. J. Wang, G.K. Aguirre, D.Y. Kimberg, A.C. Roc, L. Li, J.A. Detr

7、e (2003) Arterial spin labeling perfusion fMRI with very low task frequency. Magn. Reson. Med. 49: 796-802.9. J. Wang, D.C. Alsop, L. Li, J. Listerud, J.B. Gonzalez-At, M.D. Schnall and J.A. Detre (2002) Comparison of Quantitative Perfusion Imaging using Arterial Spin Labeling at 1.5 and 4.0 Tesla.

8、Magn. Reson. Med. 48:242-254.Theory传统fMRI: BOLD（blood oxygen level-dependent） 是合氧血红蛋白和脱氧血红蛋白的磁化率有差异，神经活动引起的血流有变化、血氧浓度及代谢率有变化的综 合机制。 Theory BOLD fMRI 广泛应用于任务激活成像研究中，特别是采用ER试验设计的个体认知和感觉试验中。由刺激引起人的BOLD信号时程，即时程脉冲反应函数，通常被称为血液动力学响应函数(HRF)。TheoryTheoryBOLD fMRI的缺陷：lThe other end of the frequency spectrum s

9、low “drifts” in fMRI signal confound comparisons of activity spaced much more than a minute apart.Experiments with longer blocks (lower task frequencies) are most affected。Theory Perfusion 可定义为血液向组织转运的稳定状态。 常将各种灌注测量方法分为两类 Exo-genous Contrast Tracer Indogenous Contrast Tracer水分子的微量运动会造成NMR信号的相移，用专门设计的相位敏感序列对这种相位变化进行检测。 TheoryASL Perfusion MRI：是利用血液中的水作为内源失踪剂，来探测CBF（cerebral blood flow）的。ASL ASL Perfusion MRI与BOLD MRI的比较ASL ASL Perfusion MRI与BOLD MRI的比较ASL ASL Perfusion MRI与BOLD MRI的比较ASL Perfusion MRI与BOLD MRI的比较ASL Perfusion MRI与Nuclear Imaging的比较 SNR 高 分辨率高 安全性好 速度快