Isobavachalcone-Corylifolinin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIsobavachalconeCat. No.: HY-13065CAS No.: 20784-50-3Synonyms: Corylifolinin; Isobacachalcone分式: CHO分量: 324.37作靶点: Autophagy; Apoptosis作通路: Autophagy; Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mont

2、h溶解性数据体外实验 DMSO : 11 mg/mL (33.91 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0829 mL 15.4145 mL 30.8290 mL5 mM 0.6166 mL 3.0829 mL 6.1658 mL10 mM 0.3083 mL 1.5414 mL 3.0829 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液

3、，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.71 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.71 mM); Clear solution3. 请依序添加每种溶剂：

4、 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (7.71 mM); Precipitated solution; Need ultrasonicBIOLOGICAL ACTIVITY物活性 Isobavachalcone(Corylifolinin)于明草，能诱导成神经细胞瘤凋亡。户使本产品发表的科研献 Int Immunopharmacol. 2013 Jan;15(1):38-41.See more customer validations on HY

5、PERLINK / www.MedChemEREFERENCES1. Jing Hui; Zhou Xinglu; Dong Xiaowu; Cao Ji; Zhu Hong; Lou Jianshu; Hu Yongzhou; He Qiaojun; Yang Bo Abrogation of Akt signaling byIsobavachalcone contributes to its anti-proliferative effects towards human cancer cells.Cancer letters (2010), 294(2):167-1772. Nishim

6、ura R et al. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol Pharm Bull.2007 Oct;30(10):1878-83.3. Zhao S, et al. Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.Int J Mol Med. 2012 Jul 16.4. Kuete V, Sa

7、ndjo LP.Isobavachalcone: an overview.Chin J Integr Med. 2012 Jul;18(7):543-7. Epub 2012 Jul 7.5. Zhang Y, Chen Z.Separation of isomeric bavachin and isobavachalcone in the fructus Psoraleae by capillary electrophoresis-massspectrometry.J Sep Sci. 2012 Jul;35(13):1644-50.McePdfHeightCaution: Product has not been fully validated for medical applications.For research us