Ganoderic-acid-A _Apoptosis Activator - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGanoderic acid ACat. No.: HY-N1447CAS No.: 81907-62-2分式: CHO分量: 516.67作靶点: Others作通路: Others储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 29 mg/mL (56.13 mM)* means s

2、oluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9355 mL 9.6774 mL 19.3547 mL5 mM 0.3871 mL 1.9355 mL 3.8709 mL10 mM 0.1935 mL 0.9677 mL 1.9355 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现

3、配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.20 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 3.94 mg/mL (7.63 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility:

4、 2.17 mg/mL (4.20 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Ganoderic acid A 能够抑制 JAK-STAT3 信号通路，也能抑制细胞增殖，存活率和 ROS。体外研究 A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cellrecognition of lymphoma 1.Ganod

5、eric acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatinmainly via the signal transducer and activator of transcription 3 suppression 2.Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2,and SOD3 by

6、 Real time PCR in a PC-3 cell in a dose-dependent manner 3.Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in adose-dependent manner, and induced obvious cell apoptosis in both cells 4.体内研究 Ganoderic acid A treatment significantly prolonged survival

7、 of EL4 challenged mice and decreased tumormetastasis to the liver 4.REFERENCES1. Radwan FF et al. Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid. J Cell Biochem. 2015Jan;116(1):102-14.2. Yao X et al. Inhibition of the JAK-STAT3 signaling pathway by ganod

8、eric acid A enhances chemosensitivity of HepG2 cells tocisplatin.Planta Med. 2012 Nov;78(16):1740-8.3. Gill BS et al. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Mol Biol Rep. 2016 Sep 17.4. Shao J et al. Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells. Nan FangYi Ke Da Xue Xue Bao. 2015 May;35(5):619-24.McePdfHeightCaution: Product has not been fully validated for medical applic