SB297006 _CCR Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESB297006Cat. No.: HY-103361CAS No.: 58816-69-6分式: CHNO分量: 342.35作靶点: CCR作通路: GPCR/G Protein; Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (438.15 mM; Nee

2、d ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.30 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.30 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 SB297006种 CCR3 拮抗剂，能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球

3、形成。IC50 & Target CCR3 1体外研究 SB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 M 1.PROTOCOLCell Assay 1 To evaluate CCR3 blocking, neural progenitor cells (NPCs) are incubated with the CCR3 antagonistSB

4、297006 (100 M) for 30 minutes and then stimulated with CCL11 (2 g/mL). After 3 days of culture, NPCsare subjected to CCK-8 assays 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Wang F, et al. CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem Cell Res Ther. 2017 Feb 7;8(1):26.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F