Glycolic-acid _Endogenous Metabolite - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGlycolic acidCat. No.: HY-W015967CAS No.: 79-14-1分式: CHO分量: 76.05作靶点: Endogenous Metabolite; Tyrosinase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/m

2、L (1314.92 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 13.1492 mL 65.7462 mL 131.4924 mL5 mM 2.6298 mL 13.1492 mL 26.2985 mL10 mM 1.3149 mL 6.5746 mL 13.1492 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助

3、溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (32.87 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (32.87 mM); Clear solution3. 请依序添加每种溶剂： 10%

4、DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (32.87 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Glycolic acid酪氨酸酶 (tyrosinase) 的抑制剂，能抑制素的形成，从减淡肤的颜。IC50 & Target Human Endogenous Metabolite体外研究 Different concentrations of Glycolic acid (GA) or LA (300 and 500

5、mg/mL) are tested on the growth of mouseand human melanoma cells. Both types of cells grow well, even in the presence of 300 mg/mL of eachchemical for 5 days. However, 500 mg/mL Glycolic acid inhibits the cell growth of mouse melanoma cells(41%) and humanmelanoma cells (27%), and 500 mg/mL of LA inh

6、ibits the growth of mouse melanoma cells(36%) 1.PROTOCOLCell Assay 1 HM3KO pigmented human melanoma cells and B16 mouse melanoma cells are cultured in Dulbeccosmodified Eagles medium supplemented with 10%fetal calf serum and appropriate amounts of antibiotics andfungizone were dissolved at a concent

7、ration of 100mg/mL in distilled water. These chemicals (e.g., GlycolicAcid ) are added to the cell cultures at final concentrations of 300 or 500 mg/mL every 2 days for 5 days 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Usuki A, et al. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol. 2003;12 Suppl2:43-50.McePdfHeightCaution: Product has not been fully validated for medical applications.For res