Otamixaban-FXV673-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOtamixabanCat. No.: HY-70035CAS No.: 193153-04-7Synonyms: FXV673分式: CHNO分量: 446.5作靶点: Factor Xa作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (111.98

2、 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2396 mL 11.1982 mL 22.3964 mL5 mM 0.4479 mL 2.2396 mL 4.4793 mL10 mM 0.2240 mL 1.1198 mL 2.2396 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储

3、备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (6.16 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (6.16 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small M

4、olecules 您边的抑制剂师www.MedChemESolubility: 2.75 mg/mL (6.16 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Otamixaban（FXV673）效的fXa选择性可逆型抑制剂，Ki为0.5nM，能抑制游离型或凝酶原酶结合型fXa。REFERENCES1. Eikelboom JW, Weitz JI.Otamixaban in acute coronary syndromes.Lancet. 2009 Sep 5;374(9692):762-4. Epub 2009 Aug 28.2. Sabatine M

5、S, Antman EM, et al. Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial.Lancet. 2009 Sep 5;374(9692):787-95. Epub 2009 Aug 283. Guertin KR, Choi YM.The discovery of the Factor Xa i

6、nhibitor otamixaban: from lead identification to clinical development.Curr MedChem. 2007;14(23):2471-81.4. Cohen M, Bhatt DL, et al. SEPIA-PCI Trial Investigators.Randomized, double-blind, dose-ranging study of otamixaban, a novel,parenteral, short-acting direct factor Xa inhibitor, in percutaneous

7、coronary intervention: the SEPIA-PCI trial.Circulation. 20075. Guertin, Kevin R.; Choi, Yong-Mi.The discovery of the factor Xa inhibitor Otamixaban: from lead identification to clinicaldevelopment.Current Medicinal Chemistry (2007), 14(23), 2471-2481.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use