Trichlormethine-hydrochloride-Tris-2-chloroethyl-amine-hydrochloride-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETrichlormethine hydrochlorideCat. No.: HY-B1249ACAS No.: 817-09-4Synonyms: Tris(2-chloroethyl)amine hydrochloride分式: CHClN分量: 240.99作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数

2、据体外实验 DMSO : 100 mg/mL (414.95 mM; Need ultrasonic)H2O : 50 mg/mL (207.48 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.1495 mL 20.7477 mL 41.4955 mL5 mM 0.8299 mL 4.1495 mL 8.2991 mL10 mM 0.4150 mL 2.0748 mL 4.1495 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验

3、动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (11.41 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (11.41

4、mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (11.41 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Trichlormethine hydrochloride治疗癌症和关节炎的细胞长抑制剂; 对类有致癌作。体外研究 Trichlormethine could be detected at a surface coverage of 0.01 mon

5、olayer, which corresponds to 20 ppm(mass/mass) for a soil having a surface area of 2.2 m2/g. TEA, the exhaustive hydrolysis product oftrichlormethine, is detected at a surface coverage of 0.001 monolayer, which corresponds to 0.86 ppm 1.体内研究 Trichlormethine hydrochloride carries a genetic risk for t

6、he postmeiotic stages of spermatogenesis and isresponsible for interference in the morphology of sperm heads through its action on spermatocytes. The toxiceffects of trichlormethine hydrochloride are found to influence the body weight of mice, to reduce the relativeweight of the testes, to damage sp

7、ermatogenesis in the seminiferous tubules, to be responsible for anappearance of multinucleate cells in the epididymides, and for an increased rate of abnormality of the headsof fully mature spermatozoa 2.PROTOCOLAnimal Mice: The genetic effect of the cytostatic trichlormethine hydrochloride is asse

8、ssed after a 1-weekAdministration 2 administration using the dominant lethal mutation test (DLM) and the sperm abnormality test. The dosage is0.5 mg/kg for 7 consecutive days, an equivalent of the human therapeutic dosage. Simultaneously, thecytostatics direct toxic effect on male sex organs is asse

9、ssed 2.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Gresham GL, et al. Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine(HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry. J Mass Spectrom. 2000 Dec;35(12):1460-9.2. Skora I, et al. Trichlormethine hydrochloride and correlation of its mutagenic and toxic effects on male germ cells in mice. Mutat Res.1992 Apr;266(2):291-7.McePdfHeightCaution: Product has not been fully validat