GLPG0492 - Androgen Receptor Modulator - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGLPG0492Cat. No.: HY-18102CAS No.: 1215085-92-9分式: CHFNO分量: 389.33作靶点: Androgen Receptor作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (128.43 mM)* means soluble, but s

2、aturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5685 mL 12.8426 mL 25.6852 mL5 mM 0.5137 mL 2.5685 mL 5.1370 mL10 mM 0.2569 mL 1.2843 mL 2.5685 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可

3、以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.42 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.42 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecu

4、les 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.42 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 GLPG0492是新型雄激素受体调节剂(SARM)。户使本产品发表的科研献 J Chromatogr A. 2019 Apr. J Steroid Biochem Mol Biol. 2019 Feb 27;189:81-86.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Nique F, et al. Identif

5、ication of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct11;55(19):8236-47.2. Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mousemodel of muscular dystrophy. Pharmacol R

6、es. 2013 Jun;72:9-24.3. Blanqu R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization.BMC Musculoskelet Disord. 2014 Sep 3;15:291.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820