HA-100 - PKA 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHA-100Cat. No.: HY-100984CAS No.: 84468-24-6分式: CHNOS分量: 277.34作靶点: PKA; PKC; Myosin作通路: Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; Epigenetics;TGF-beta/Smad; Cytoskeleton储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mont

2、hs-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (540.85 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.6057 mL 18.0284 mL 36.0568 mL5 mM 0.7211 mL 3.6057 mL 7.2114 mL10 mM 0.3606 mL 1.8028 mL 3.6057 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解

3、案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.01 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.01 mM); Clear soluti

4、on3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (9.01 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 HA-100cGMP 依赖性蛋激酶 (PKG)，cAMP 依赖性蛋激酶 (PKA)，蛋激酶 C (PKC) 和 MLC 激酶 (MLC-kinase) 的抑制剂，其 IC50 值分别为 4, 8, 12 和 240 M。IC50 & Target PKC PKG PKA MLCK12 M

5、 (IC50) 4 M (IC50) 8 M (IC50) 240 M (IC50)REFERENCES1. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors,isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58