Acetoacetic-acid-sodium-salt-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAcetoacetic acid sodium saltCat. No.: HY-112540BCAS No.: 623-58-5分式: CHNaO分量: 124.07作靶点: Others作通路: Others储存式: -20C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外实验 H2O : 50 mg/m

2、L (403.00 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 8.0600 mL 40.2998 mL 80.5997 mL5 mM 1.6120 mL 8.0600 mL 16.1199 mL10 mM 0.8060 mL 4.0300 mL 8.0600 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Acetoacetic acid sodium salt种酯化脂 酸代谢物，参与类糖尿病的发展。Ace

3、toacetic acid sodiumsalt 诱导氧化应激，抑制肝细胞中极低密度脂蛋的组装 1。体外研究Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein inbovine hepatocytes 1.Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH)group, decreas

4、es mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in allgroups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition,1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEAcetoacetic acid down-regulates the mRNA expression of apolipoprotei

5、n B100 (ApoB100), apolipoprotein E(ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG)accumulation is increased in these bovine hepatocytes 1.REFERENCES1. Shi X, et al. Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. JDairy Res. 2016 Nov;83(4):442-446.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;