Dirithromycin-LY237216-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDirithromycinCat. No.: HY-B0643CAS No.: 62013-04-1Synonyms: LY237216分式: CHNO分量: 835.07作靶点: Bacterial作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 Ethanol : 50 mg/mL (59.88 mM)

2、DMSO : 33.33 mg/mL (39.91 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.1975 mL 5.9875 mL 11.9750 mL5 mM 0.2395 mL 1.1975 mL 2.3950 mL10 mM 0.1198 mL 0.5988 mL 1.1975 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适

3、当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.99 mM); Clear solution2. 请依序添加每种溶剂： 10% EtOH 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您边的抑制剂师www.

4、MedChemESolubility: 2.5 mg/mL (2.99 mM); Clear solution3. 请依序添加每种溶剂： 10% EtOH 90% corn oilSolubility: 2.5 mg/mL (2.99 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Dirithromycin(LY 237216)环内酯类糖肽抗素，能与细菌核糖体70S中的50S亚基相结合。REFERENCES1. Brogden, R.N. and D.H. Peters, Dirithromycin. A review of its antimicrobi

5、al activity, pharmacokinetic properties and therapeutic efficacy.Drugs, 1994. 48(4): p. 599-616.2. Wintermeyer, S.M., S.M. Abdel-Rahman, and M.C. Nahata, Dirithromycin: a new macrolide. Ann Pharmacother, 1996. 30(10): p. 1141-9.3. Sides, G.D., et al., Pharmacokinetics of dirithromycin. J Antimicrob Chemother, 1993. 31 Suppl C: p. 65-75.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0