Norverapamil-hydrochloride-racemic-Norverapamil-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENorverapamil hydrochlorideCat. No.: HY-100750CAS No.: 67812-42-4Synonyms: ()-Norverapamil hydrochloride; D591 hydrochlorid分式: CHClNO分量: 477.04作靶点: Calcium Channel; Drug Metabolite作通路: Membrane Transporter/Ion Channel; Neuronal S

2、ignaling;Metabolic Enzyme/Protease储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 31 mg/mL (64.98 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0963 mL 10.4813 mL 20.9626 mL5 mM 0.4193 mL 2.

3、0963 mL 4.1925 mL10 mM 0.2096 mL 1.0481 mL 2.0963 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Norverapamil hydrochloride个钙通道阻滞剂,是verapamil主要的活性代谢物。REFERENCES1. Adams KN et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-media

4、ted tolerance to1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEmultiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.2. Singhal P et al. Enantiomeric separation of verapamil and its active metabolite, norverapamil, and simultaneous quantification in humanplasma by LC-ESI-MS-MS. J

5、Chromatogr Sci. 2012 Oct;50(9):839-48.3. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predictstereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021