Fludarabine-F-ara-A-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFludarabineCat. No.: HY-B0069CAS No.: 21679-14-1Synonyms: F-ara-A; NSC 118218分式: CHFNO分量: 285.23作靶点: Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT作通路: Cell Cycle/DNA Damage; JAK/STAT Signaling; Stem Cell/Wnt储存式: Powd

2、er -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 160 mg/mL (560.95 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.5059 mL 17.5297 mL 35.0594 mL5 mM 0.7012 mL 3.5059 mL 7.0119 mL10 mM 0.3506 mL 1.7530 mL 3.5059 mL请根据产品在不同溶剂

3、中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Fludarabine (F-ara-A; NSC 118218)是DNA 合成抑制剂，也抑制 STAT1 磷酸化。户使本产品发表的科研献1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE J Infect. 2019 Jun 18. pii: S0163-4453(19)30187-2. J Mol Med (Berl). 2019 Jun 14. Int J Mol Sci. 2019 Feb 3;20(3). pii: E663

4、. Front Endocrinol. 2019 Jul. Patent. US20160222465A1.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Rai KR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000 Dec14;343(24):1750-7.2. Tournilhac O, et al. Impac

5、t of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilizationin B-cell chronic lymphocytic leukemia. Blood. 2004 Jan 1;103(1):363-5. Epub 2003 Sep 11.3. Liang YB, et al. Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages intoM1 type. Mol Med Rep. 2017 Nov;16(5):6405-6411.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;