Lavendustin-A-RG-14355-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELavendustin ACat. No.: HY-18963CAS No.: 125697-92-9Synonyms: RG-14355分式: CHNO分量: 381.38作靶点: EGFR作通路: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外

2、实验 DMSO : 250 mg/mL (655.51 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6221 mL 13.1103 mL 26.2206 mL5 mM 0.5244 mL 2.6221 mL 5.2441 mL10 mM 0.2622 mL 1.3110 mL 2.6221 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制

3、澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.45 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.45 mM); Clear solutionBIOLO

4、GICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Lavendustin A (RG-14355), 可从Streptomyces Griseolavendus 中分离得到，种有效的、特异性的、ATP竞争性的酪氨酸激酶抑制剂，对表长因受体 (EGFR) 相关酪氨酸激酶的 IC50 值为 11 ng/mL 1。 能抑制管内长因诱导的管成，阻断LTPGABA-A的诱导 2 3。IC50 & Target IC50: 11 ng/mL (EGFR-associated tyrosine kinase) 1.REFER

5、ENCES1. Onoda T, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7.2. Hu DE, et al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995Jan;11

6、4(2):262-8.3. Gubellini P, et al. Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rathippocampus. J Neurosci. 2005 Jun 15;25(24):5796-802.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820