Parecoxib-SC-69124-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEParecoxibCat. No.: HY-17474CAS No.: 198470-84-7Synonyms: SC 69124分式: CHNOS分量: 370.42作靶点: COX作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (134.98 mM)*

2、 means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6996 mL 13.4982 mL 26.9964 mL5 mM 0.5399 mL 2.6996 mL 5.3993 mL10 mM 0.2700 mL 1.3498 mL 2.6996 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验

3、的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.75 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.75 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOL

4、OGICAL ACTIVITY物活性 Parecoxib是选择性COX-2抑制剂。IC50 & Target COX-2户使本产品发表的科研献 J Pharm Biomed Anal. 2018 May 22;158:1-7.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Ye Z, et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apopto

5、sis byphosphorylation Akt and GSK-3. Neurochem Res. 2012 Feb;37(2):321-9.2. Schr?der H, et al. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293cells and rat brain tissue. Neurochem Int. 2011 Jan;58(1):9-13.3. Guo YJ, et al. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp TherMed. 2013 Jul;6(1):275-279.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37