ST271 - Phospholipase 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEST271Cat. No.: HY-103097CAS No.: 106392-48-7分式: CHNO分量: 272.34作靶点: Phospholipase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 110 mg/mL (403.91 mM)* means so

2、luble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.6719 mL 18.3594 mL 36.7188 mL5 mM 0.7344 mL 3.6719 mL 7.3438 mL10 mM 0.3672 mL 1.8359 mL 3.6719 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 ST271种蛋质酪氨酸激酶 (PTK) 抑制剂，能够抑制 fMet-Leu-Phe 和 PAF 引起的

3、phospholipase D 活化，IC50 值分别为 6.7 和 9 M。IC50 & Target IC50: 6.7 M (phospholipase D, stimulated by fMet-Leu-Phe), 9 M (phospholipase D, stimulated by PAF) 3体外研究ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets1/2 Master of Small Molecules 您边的抑制

4、剂师www.MedChemE1. ST271 (100 M) causes complete inhibition of formation of inositol phosphates induced by FcRII cross-linking, but also induces a small ( 2.REFERENCES1. Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le

5、-grand).1994 Jul;40(5):627-34.2. Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinaseinhibitors and associated with tyrosine phosphorylation of the receptor.3. Uings IJ, et al. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the humanneutrophil. Biochem J. 1992 Feb 1;281 (Pt 3):597-600.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379