Clascoterone-Cortexolone-17-alpha-propionate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEClascoteroneCat. No.: HY-13331CAS No.: 19608-29-8Synonyms: Cortexolone 17 alpha-propionate; Cortexolone 17-propionate;CB-03-01分式: CHO分量: 402.52作靶点: Androgen Receptor作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (248.43 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4843 mL 12.4217 mL 24.8435 mL5 mM 0.4969 mL 2.4843 mL 4.9687 mL10 mM 0.2484 mL 1.2422 mL 2.4843 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的

3、实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (6.83 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules

4、 您边的抑制剂师www.MedChemESolubility: 2.75 mg/mL (6.83 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (6.83 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Clascoterone是新型的局部和外周 的雄性激素拮抗剂。IC50 & Target Androgen Receptor 1.体内研究 Clascoterone is a new potent topical antiandrogen potent

5、ially useful in acne vulgaris. Clascoterone 1%cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 00017), ILC (P= 00134) and ASI (P = 00090), and also clinically more effective than comparator. The product also induceda faster attainment of 50% improvement in

6、all the above parameters.REFERENCES1. Trifu V, et al. Cortexolone 17-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilotrandomized, double-blind comparative study vs. placebo and tretinoin 005% cream. Br J Dermatol. 2011 Jul;165(1):177-83.2. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgenantagonist. Arzneimittelforschung. 2004;54(12):881-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use onl