UNC-926 - Epigenetic Reader Domain 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEUNC-926Cat. No.: HY-16510CAS No.: 1184136-10-4分式: CHBrNO分量: 337.25作靶点: Epigenetic Reader Domain作通路: Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 155 mg/mL (459.60 mM)* means s

2、oluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9652 mL 14.8258 mL 29.6516 mL5 mM 0.5930 mL 2.9652 mL 5.9303 mL10 mM 0.2965 mL 1.4826 mL 2.9652 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 UNC-926是甲基-赖氨酸 (Kme) 阅读结构域抑制剂; 抑制L3MBTL1的 IC50 值为3.

3、9 M。IC50 & Target IC50: 3.9 M (L3MBTL1) 1体外研究UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 M. L3MBTL1UNC-926 also exhibits a low micromolar affinityfor the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEC

4、BX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits theL3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect onthe binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1 1.REFERENCES1. Herold JM, et al. Structureactivity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):4551.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>