Metiamide-SK-F-92058-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMetiamideCat. No.: HY-15540CAS No.: 34839-70-8Synonyms: SK&F 92058分式: CHNS分量: 244.38作靶点: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months

2、-20C 1 month溶解性数据体外实验 DMSO : 2.4 mg/mL (9.82 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.0920 mL 20.4599 mL 40.9199 mL5 mM 0.8184 mL 4.0920 mL 8.1840 mL10 mM - - -请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Metiamide (SK&F 92

3、058)是组胺H2受体拮抗剂。IC50 & Target Ki: 0.92 uM (H2 receptor)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE体外研究 Metiamide (SK&F 92058) is a competitive with aldehyde substrates and noncompetitive with the Human E3Aldehyde Dehydrogenase coenzyme, binding to both the free E3 isozyme and the enzymecoenzyme

4、 binarycomplex with Ki values of 0.92 M glycolaldehyde as the varied substrate 1. Data is got as percentagechange in GTPase activity induced by metiamide compared with the GTPase activity stimulated by HA (100 M) 2.REFERENCES1. Alexandra Kikonyogo ,Regina Pietruszko, Cimetidine and Other H2-Receptor

5、 Antagonists as Inhibitors of Human E3 AldehydeDehydrogenase. Molecular Pharmacology 1997; 52: 2267-271.2. Hendrik Preuss, Prasanta Ghorai1, Anja Kraus, Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and CanineHistamine H2 Receptors. JPET 2007 vol. 321no. 3 983-995.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021