Smurf1-IN-A01-A01-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESmurf1-IN-A01Cat. No.: HY-110195CAS No.: 1007647-73-5Synonyms: A01分式: CHClFNOS分量: 512.93作靶点: Others作通路: Others储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 62.5 mg/mL

2、 (121.85 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9496 mL 9.7479 mL 19.4958 mL5 mM 0.3899 mL 1.9496 mL 3.8992 mL10 mM 0.1950 mL 0.9748 mL 1.9496 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，

3、当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.06 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.06 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.Me

4、dChemE物活性 Smurf1-IN-A01 (A01)种泛素连接酶 Smad 泛素化调节因-1 (Smurf1) 抑制剂，kd 值为 3.664nM，Smurf1-IN-A01 通过抑制 Smurf1 介导的 Smad1/5 降解来提 BMP-2 的反应性 1。IC50 & Target Kd: 3.664 nM (Smurf1) 1REFERENCES1. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5degradation. Sci Rep. 2014 May 14;4:4965.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax