CK-869-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECK-869Cat. No.: HY-16927CAS No.: 388592-44-7分式: CHBrNOS分量: 394.28作靶点: Arp2/3 Complex作通路: Cytoskeleton储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMS : 75 mg/mL (190.22 mM; Need ultrasonic)H2O

2、: 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.34 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.34 mM); Suspended solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.34 mM); C

3、lear solutionBIOLOGICAL ACTIVITY物活性 CK-869肌动蛋相关蛋 2/3 复合体 (ARP2/3) 的抑制剂，其 IC50 值为 7 M。IC50 & Target IC50: 7 M (ARP2/3) 1.体外研究 CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 M 1. CK-869significantly inhibits MT polymerization even at a concentration of 25 M 2.REFE

4、RENCES1. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformationalchange. Chem Biol. 2013 May 23;20(5):701-12.2. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro andin vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F