ML329-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEML329Cat. No.: HY-101464CAS No.: 19992-50-8分式: CHNOS分量: 328.34作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 31 mg/mL (94.41 mM)* means soluble, but saturation unknow

2、n.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0456 mL 15.2281 mL 30.4562 mL5 mM 0.6091 mL 3.0456 mL 6.0912 mL10 mM 0.3046 mL 1.5228 mL 3.0456 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 ML329MITF的分抑制剂，抑制TRPM-1启动活性的IC50值为1.2 M。IC50 & Target IC50: 1.2 M (TRPM-1) 1体外研究

3、ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genesand blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEindirectly interact with MITF or

4、 components of the MITF regulatory network. As a transcription factor thatregulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing thespecific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment ofmelanoma. ML329 sh

5、ows specific activity against the MITF-dependent cells, primary melanocytes but noeffect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, includingpigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful inelucidatin

6、g the role of MITF in melanocyte lineage development and in melanoma disease progression 1.REFERENCES1. Faloon PW, et al. A Small Molecule Inhibitor of the MITF Molecular Pathway. Probe Reports from the NIH Molecular Libraries ProgramInternet. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012 Dec 13.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: