Azilsartan-TAK-536-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAzilsartanCat. No.: HY-14914CAS No.: 147403-03-0Synonyms: TAK-536分式: CHNO分量: 456.45作靶点: Angiotensin Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 25 mg/mL (54.7

2、7 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.48 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.48 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Azilsartan(TAK-536)特异且活性的管紧张素1型受体拮抗剂，I

3、C50为2.6 nM。户使本产品发表的科研献 J Lumin. 2018 Nov; 203;616-628. Oncotarget. 2017 Apr 11;8(15):24099-24109.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Ojima M, Igata H, Tanaka M, In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor bi

4、ndingand function studies. J Pharmacol Exp Ther. 2011 Mar;336(3):801-8.2. Weltman R, Brands CM, Corral E, Assessment of the environmental fate and effects of azilsartan, a selective antagonist of angiotensin IItype 1. Chemosphere. 2012 Jun;87(11):1323-9.3. Pierini D, Anderson KV. Azilsartan medoxomi

5、l/chlorthalidone: a new fixed-dose combination antihypertensive. Ann Pharmacother. 2013May;47(5):694-703.4. Iwai M, Chen R, Imura Y, Horiuchi M. TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation.Am J Hypertens. 2007 May;20(5):579-86.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-