ELN-441958 - Bradykinin Receptor Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEELN-441958Cat. No.: HY-15043CAS No.: 913064-47-8分式: CHClNO分量: 501.02作靶点: Bradykinin Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (199.59 mM; Need ult

2、rasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9959 mL 9.9796 mL 19.9593 mL5 mM 0.3992 mL 1.9959 mL 3.9919 mL10 mM 0.1996 mL 0.9980 mL 1.9959 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存

3、；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.99 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.99 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.99 mM); Clear

4、 solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 ELN-441958有效的B1受体拮抗剂, 抑制B1激动剂配体3H DAKD与IMR-90细胞结合, Ki值为 0.26 nM, ELN-441958抑制B1受体作抑制 B2受体具有更的选择性, 抑制/阿受体选择性分别500和2000多倍。REFERENCES1. Hawkinson JE, et al. Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptorantagonist ELN441958. J Pharmacol Exp Ther.2007 Aug;322(2):619-630.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>