Sodium-gualenate-Guaiazulenesulfonate-sodium-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESodium gualenateCat. No.: HY-B2191CAS No.: 6223-35-4Synonyms: Guaiazulenesulfonate sodium分式: CHNaOS分量: 300.35作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 30 mg/mL (

2、99.88 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3294 mL 16.6472 mL 33.2945 mL5 mM 0.6659 mL 3.3294 mL 6.6589 mL10 mM 0.3329 mL 1.6647 mL 3.3294 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Sodium gualenate (Guaiazulenesulfonate sodiu

3、m)桂烯的亲性衍物，具有优良的抗炎和愈伤作，主 于治疗指肠溃疡，胃溃疡和胃炎。体外研究Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at roomtemperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was foundthat a kneaded mixture of Sodium gualenate and cornstarch (w

4、eight ratio; 1:250) for tableting with water is1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEstable. So, during production, Sodium gualenate could be stabilized using water 1. Sodium gualenateslightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyt

5、eemigration induced by fMLP 2.体内研究 Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined asthe main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions invivo have also been shown 2.REFERENCES1. Nakamichi K

6、, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur JPharm Biopharm. 2003 Nov;56(3):347-54.2. Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem BiolDrug Des. 2016 Aug;88(2):264-71.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: